Calcium in PDB 2qtw: The Crystal Structure of PCSK9 at 1.9 Angstroms Resolution Reveals Structural Homology to Resistin Within the C-Terminal Domain

The structure of The Crystal Structure of PCSK9 at 1.9 Angstroms Resolution Reveals Structural Homology to Resistin Within the C-Terminal Domain, PDB code: 2qtw was solved by E.N.Hampton, M.W.Knuth, J.Li, J.L.Harris, S.A.Lesley, G.Spraggon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 1.90
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	62.427, 70.149, 148.590, 90.00, 90.00, 90.00
R / Rfree (%)	19.2 / 23.9

The binding sites of Calcium atom in the The Crystal Structure of PCSK9 at 1.9 Angstroms Resolution Reveals Structural Homology to Resistin Within the C-Terminal Domain (pdb code 2qtw). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the The Crystal Structure of PCSK9 at 1.9 Angstroms Resolution Reveals Structural Homology to Resistin Within the C-Terminal Domain, PDB code: 2qtw:

Calcium binding site 1 out of 1 in the The Crystal Structure of PCSK9 at 1.9 Angstroms Resolution Reveals Structural Homology to Resistin Within the C-Terminal Domain


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of The Crystal Structure of PCSK9 at 1.9 Angstroms Resolution Reveals Structural Homology to Resistin Within the C-Terminal Domain within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1 b:61.2 occ:1.00 O B:HOH1231 2.2 39.2 1.0 O B:VAL333 2.6 20.6 1.0 OG1 B:THR335 2.6 13.8 1.0 OD2 B:ASP360 2.8 21.3 1.0 O B:CYS358 3.1 17.9 1.0 O B:ALA330 3.3 26.5 1.0 CB B:THR335 3.4 16.5 1.0 O B:ALA328 3.5 16.8 1.0 O B:HOH1013 3.6 30.8 1.0 N B:THR335 3.8 15.5 1.0 C B:VAL333 3.8 19.6 1.0 CG B:ASP360 3.9 19.2 1.0 O B:HOH1030 4.0 34.1 1.0 O B:PRO331 4.1 27.8 1.0 C B:CYS358 4.1 18.7 1.0 C B:ALA330 4.2 25.3 1.0 OD1 B:ASP360 4.2 19.5 1.0 CA B:THR335 4.2 14.4 1.0 CA B:PRO331 4.3 29.7 1.0 C B:PRO331 4.4 29.6 1.0 CG2 B:THR335 4.6 14.3 1.0 C B:ILE334 4.6 15.2 1.0 CA B:CYS358 4.6 15.7 1.0 C B:ALA328 4.7 15.6 1.0 N B:VAL333 4.7 21.2 1.0 CA B:ILE334 4.7 16.2 1.0 CA B:VAL333 4.7 20.2 1.0 N B:ILE334 4.7 16.7 1.0 N B:PRO331 4.7 30.1 1.0 CB B:CYS358 4.9 17.0 1.0 CB B:VAL333 4.9 21.0 1.0 N B:ALA330 5.0 21.3 1.0

E.N.Hampton, M.W.Knuth, J.Li, J.L.Harris, S.A.Lesley, G.Spraggon. The Self-Inhibited Structure of Full-Length PCSK9 at 1.9 A Reveals Structural Homology with Resistin Within the C-Terminal Domain. Proc.Natl.Acad.Sci.Usa V. 104 14604 2007.
ISSN: ISSN 0027-8424
PubMed: 17804797
DOI: 10.1073/PNAS.0703402104