Calcium in PDB 2qvm: The Second CA2+-Binding Domain of the Na+-CA2+ Exchanger Is Essential For Regulation: Crystal Structures and Mutational Analysis

The structure of The Second CA2+-Binding Domain of the Na+-CA2+ Exchanger Is Essential For Regulation: Crystal Structures and Mutational Analysis, PDB code: 2qvm was solved by V.Chaptal, G.Mercado Besserer, J.Abramson, D.Cascio, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.80 / 1.70
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	86.030, 59.232, 22.592, 90.00, 90.00, 90.00
R / Rfree (%)	18.5 / 21.9

The binding sites of Calcium atom in the The Second CA2+-Binding Domain of the Na+-CA2+ Exchanger Is Essential For Regulation: Crystal Structures and Mutational Analysis (pdb code 2qvm). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the The Second CA2+-Binding Domain of the Na+-CA2+ Exchanger Is Essential For Regulation: Crystal Structures and Mutational Analysis, PDB code: 2qvm:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the The Second CA2+-Binding Domain of the Na+-CA2+ Exchanger Is Essential For Regulation: Crystal Structures and Mutational Analysis


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of The Second CA2+-Binding Domain of the Na+-CA2+ Exchanger Is Essential For Regulation: Crystal Structures and Mutational Analysis within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1001 b:12.6 occ:1.00 O A:GLU580 2.4 16.1 1.0 OD1 A:ASP578 2.4 14.0 1.0 O A:HOH15 2.4 15.4 1.0 O A:HOH8 2.4 15.4 1.0 OE2 A:GLU516 2.4 14.9 1.0 OE1 A:GLU516 2.5 12.7 1.0 OE1 A:GLU648 2.5 12.8 1.0 OE2 A:GLU648 2.6 14.6 1.0 CD A:GLU516 2.8 12.0 1.0 CD A:GLU648 2.9 10.9 1.0 CG A:ASP578 3.4 15.2 1.0 C A:GLU580 3.5 17.6 1.0 OD2 A:ASP578 3.7 15.0 1.0 O A:HOH10 4.1 15.7 1.0 N A:GLU580 4.1 18.4 1.0 CA A:GLU580 4.3 18.3 1.0 CG A:GLU516 4.4 11.2 1.0 O A:ASP578 4.4 14.6 1.0 CG A:GLU648 4.4 13.6 1.0 N A:TYR581 4.5 16.4 1.0 C A:ASP578 4.6 15.8 1.0 N A:GLU582 4.6 17.8 1.0 CA A:TYR581 4.7 16.6 1.0 CB A:GLU580 4.7 19.3 1.0 O A:HOH6 4.7 13.1 1.0 CB A:ASP578 4.7 15.1 1.0 OG A:SER649 4.7 16.7 1.0 N A:SER649 4.7 12.0 1.0 O A:HOH9 4.8 15.8 1.0 N A:ASP578 4.8 15.6 1.0 OD1 A:ASP577 4.8 18.3 1.0 N A:TYR650 4.9 14.5 1.0 CA A:ASP578 4.9 15.6 1.0 CA A:GLU648 5.0 12.5 1.0

Calcium binding site 2 out of 2 in the The Second CA2+-Binding Domain of the Na+-CA2+ Exchanger Is Essential For Regulation: Crystal Structures and Mutational Analysis


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of The Second CA2+-Binding Domain of the Na+-CA2+ Exchanger Is Essential For Regulation: Crystal Structures and Mutational Analysis within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1002 b:14.9 occ:1.00 OD2 A:ASP578 2.3 15.0 1.0 OD1 A:ASP552 2.3 14.3 1.0 O A:HOH11 2.4 21.1 1.0 O A:HOH30 2.4 30.1 1.0 O A:HOH9 2.5 15.8 1.0 O A:HOH26 2.5 18.5 1.0 O A:HOH6 2.5 13.1 1.0 CG A:ASP578 3.4 15.2 1.0 CG A:ASP552 3.5 13.3 1.0 CB A:ASP578 3.9 15.1 1.0 O A:HOH8 4.0 15.4 1.0 NZ A:LYS585 4.2 27.4 1.0 OE2 A:GLU516 4.2 14.9 1.0 OD2 A:ASP552 4.3 13.5 1.0 OE1 A:GLU582 4.4 25.5 1.0 OD1 A:ASP578 4.4 14.0 1.0 O A:HOH12 4.4 13.2 1.0 CB A:ASP552 4.5 11.3 1.0 O A:ILE576 4.5 14.2 1.0 O A:GLU551 4.5 15.4 1.0 CA A:ASP552 4.5 11.2 1.0 OE2 A:GLU551 4.7 23.6 0.5 O A:HOH1 4.9 10.7 1.0 C A:GLU551 4.9 15.2 1.0 N A:ASP552 5.0 13.2 1.0

G.Mercado Besserer, M.Ottolia, D.A.Nicoll, V.Chaptal, D.Cascio, K.D.Philipson, J.Abramson. The Second CA2+-Binding Domain of the Na+ CA2+ Exchanger Is Essential For Regulation: Crystal Structures and Mutational Analysis Proc.Natl.Acad.Sci.Usa V. 104 18467 2007.
ISSN: ISSN 0027-8424
PubMed: 17962412
DOI: 10.1073/PNAS.0707417104