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Calcium in PDB 2xeg: Human Glutamate Carboxypeptidase II in Complex with Antibody-Recruiting Molecule Arm-P4

Enzymatic activity of Human Glutamate Carboxypeptidase II in Complex with Antibody-Recruiting Molecule Arm-P4

All present enzymatic activity of Human Glutamate Carboxypeptidase II in Complex with Antibody-Recruiting Molecule Arm-P4:
3.4.17.21;

Protein crystallography data

The structure of Human Glutamate Carboxypeptidase II in Complex with Antibody-Recruiting Molecule Arm-P4, PDB code: 2xeg was solved by A.X.Zhang, R.P.Murelli, C.Barinka, J.Michel, A.Cocleaza, W.L.Jorgensen, J.Lubkowski, D.A.Spiegel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 1.59
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 101.707, 130.039, 159.026, 90.00, 90.00, 90.00
R / Rfree (%) 16.858 / 19.063

Other elements in 2xeg:

The structure of Human Glutamate Carboxypeptidase II in Complex with Antibody-Recruiting Molecule Arm-P4 also contains other interesting chemical elements:

Chlorine (Cl) 1 atom
Zinc (Zn) 2 atoms

Calcium Binding Sites:

The binding sites of Calcium atom in the Human Glutamate Carboxypeptidase II in Complex with Antibody-Recruiting Molecule Arm-P4 (pdb code 2xeg). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Human Glutamate Carboxypeptidase II in Complex with Antibody-Recruiting Molecule Arm-P4, PDB code: 2xeg:

Calcium binding site 1 out of 1 in 2xeg

Go back to Calcium Binding Sites List in 2xeg
Calcium binding site 1 out of 1 in the Human Glutamate Carboxypeptidase II in Complex with Antibody-Recruiting Molecule Arm-P4


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Human Glutamate Carboxypeptidase II in Complex with Antibody-Recruiting Molecule Arm-P4 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca1753

b:4.6
occ:1.00
 O A:TYR272 2.3 14.8 1.0
OE2 A:GLU436 2.3 15.9 1.0
O A:HOH2196 2.4 14.3 1.0
O A:THR269 2.4 14.3 1.0
OG1 A:THR269 2.5 14.7 1.0
OE2 A:GLU433 2.5 16.3 1.0
OE1 A:GLU433 2.5 15.3 1.0
CD A:GLU433 2.8 13.8 1.0
C A:THR269 3.3 14.9 1.0
CB A:THR269 3.3 14.8 1.0
CD A:GLU436 3.4 16.7 1.0
C A:TYR272 3.4 14.6 1.0
OE1 A:GLU436 3.9 14.5 1.0
CA A:THR269 3.9 15.3 1.0
N A:TYR272 4.0 13.8 1.0
CA A:PRO273 4.2 15.3 1.0
CB A:ASP266 4.2 14.4 1.0
N A:PRO270 4.2 14.5 1.0
N A:ALA274 4.3 15.4 1.0
N A:PRO273 4.3 15.4 1.0
CG A:GLU433 4.3 13.6 1.0
CA A:TYR272 4.4 15.2 1.0
C A:PRO273 4.4 16.0 1.0
N A:ASP266 4.4 13.0 1.0
CA A:PRO270 4.5 14.6 1.0
N A:GLY271 4.5 13.8 1.0
O A:ALA264 4.5 15.6 1.0
O A:ASP266 4.5 15.2 1.0
N A:THR269 4.6 14.8 1.0
CG2 A:THR269 4.7 15.1 1.0
CG A:GLU436 4.7 13.8 1.0
C A:PRO270 4.7 14.4 1.0
OD2 A:ASP266 4.7 16.5 1.0
CA A:ASP266 4.9 14.0 1.0
CB A:ALA274 4.9 16.0 1.0
CB A:GLU436 4.9 13.3 1.0
CA A:GLU433 5.0 12.9 1.0

Reference:

A.X.Zhang, R.P.Murelli, C.Barinka, J.Michel, A.Cocleaza, W.L.Jorgensen, J.Lubkowski, D.A.Spiegel. A Remote Arene-Binding Site on Prostate Specific Membrane Antigen Revealed By Antibody-Recruiting Small Molecules. J.Am.Chem.Soc. V. 132 12711 2010.
ISSN: ISSN 0002-7863
PubMed: 20726553
DOI: 10.1021/JA104591M
Page generated: Sat Dec 12 03:58:14 2020

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