Calcium in PDB 2xn7: Crystal Structure of Thyroxine-Binding Globulin Complexed with Thyroxine-Fluoresein (T405-Cf)

The structure of Crystal Structure of Thyroxine-Binding Globulin Complexed with Thyroxine-Fluoresein (T405-Cf), PDB code: 2xn7 was solved by X.Qi, Y.Yan, Z.Wei, A.Zhou, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	87.01 / 1.43
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	174.030, 42.550, 56.220, 90.00, 90.00, 90.00
R / Rfree (%)	19.884 / 21.807

The structure of Crystal Structure of Thyroxine-Binding Globulin Complexed with Thyroxine-Fluoresein (T405-Cf) also contains other interesting chemical elements:

Iodine

(I)

4 atoms

The binding sites of Calcium atom in the Crystal Structure of Thyroxine-Binding Globulin Complexed with Thyroxine-Fluoresein (T405-Cf) (pdb code 2xn7). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Crystal Structure of Thyroxine-Binding Globulin Complexed with Thyroxine-Fluoresein (T405-Cf), PDB code: 2xn7:

Calcium binding site 1 out of 1 in the Crystal Structure of Thyroxine-Binding Globulin Complexed with Thyroxine-Fluoresein (T405-Cf)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of Thyroxine-Binding Globulin Complexed with Thyroxine-Fluoresein (T405-Cf) within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1358 b:69.3 occ:1.00 O1 A:EDO1357 2.7 53.0 1.0 OE1 A:GLU200 3.0 28.1 0.5 CD A:GLU200 3.4 27.1 0.5 OE2 A:GLU200 3.5 27.2 0.5 C1 A:EDO1357 3.5 53.3 1.0 O A:HOH2271 3.6 42.5 1.0 N A:ASP201 3.7 25.2 1.0 CG A:ASP201 3.9 31.2 1.0 CA A:GLU200 4.0 22.1 1.0 OD2 A:ASP201 4.1 35.5 1.0 OD1 A:ASP201 4.1 35.8 1.0 O A:THR199 4.3 21.3 1.0 CB A:ASP201 4.3 27.9 1.0 C A:GLU200 4.4 23.2 1.0 CG A:GLU200 4.6 25.2 1.0 CA A:ASP201 4.6 26.3 1.0 CB A:GLU200 4.7 22.3 1.0 C2 A:EDO1357 4.9 53.4 1.0

X.Qi, F.Loiseau, W.L.Chan, Y.Yan, Z.Wei, L.G.Milroy, R.M.Myers, S.V.Ley, R.J.Read, R.W.Carrell, A.Zhou. Allosteric Modulation of Hormone Release From Thyroxine and Corticosteroid Binding-Globulins. J.Biol.Chem. V. 286 16163 2011.
ISSN: ISSN 0021-9258
PubMed: 21325280
DOI: 10.1074/JBC.M110.171082