Calcium in PDB 2xo3: Human Annexin V with Incorporated Methionine Analogue Homopropargylglycine

The structure of Human Annexin V with Incorporated Methionine Analogue Homopropargylglycine, PDB code: 2xo3 was solved by M.Debela, L.Merkel, P.Goettig, N.Budisa, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.96 / 2.30
Space group	H 3
Cell size a, b, c (Å), α, β, γ (°)	154.965, 154.965, 35.580, 90.00, 90.00, 120.00
R / Rfree (%)	26.2 / 29.1

The binding sites of Calcium atom in the Human Annexin V with Incorporated Methionine Analogue Homopropargylglycine (pdb code 2xo3). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Human Annexin V with Incorporated Methionine Analogue Homopropargylglycine, PDB code: 2xo3:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Human Annexin V with Incorporated Methionine Analogue Homopropargylglycine


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Human Annexin V with Incorporated Methionine Analogue Homopropargylglycine within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1320 b:25.3 occ:1.00 O3 A:SO41322 2.4 33.6 1.0 O A:GLY188 2.5 25.0 1.0 OE1 A:GLU228 2.6 15.4 1.0 OE2 A:GLU228 2.6 19.3 1.0 O A:GLY183 2.6 15.2 1.0 O A:HOH2206 2.7 4.5 1.0 O A:LYS186 2.7 19.9 1.0 O4 A:SO41322 2.9 32.2 1.0 CD A:GLU228 2.9 16.9 1.0 S A:SO41322 3.2 31.9 1.0 C A:GLY183 3.3 14.4 1.0 C A:GLY188 3.6 25.0 1.0 C A:LYS186 3.8 20.3 1.0 N A:GLY188 3.9 23.4 1.0 CA A:GLY183 3.9 13.5 1.0 N A:GLU184 4.1 14.0 1.0 O1 A:SO41322 4.1 34.5 1.0 OG1 A:THR189 4.2 23.2 1.0 O2 A:SO41322 4.3 34.6 1.0 CA A:GLY188 4.3 25.0 1.0 N A:LYS186 4.3 18.8 1.0 CG A:GLU228 4.4 20.2 1.0 CA A:GLU184 4.4 16.5 1.0 CA A:LYS186 4.4 20.4 1.0 C A:GLU184 4.5 17.8 1.0 CB A:LYS186 4.5 20.0 1.0 O A:GLU184 4.6 19.1 1.0 N A:THR189 4.6 24.2 1.0 CA A:THR189 4.8 24.3 1.0 N A:TRP187 4.8 22.2 1.0 C A:TRP187 4.8 25.4 1.0 CA A:TRP187 5.0 25.0 1.0 N A:GLY183 5.0 15.2 1.0

Calcium binding site 2 out of 2 in the Human Annexin V with Incorporated Methionine Analogue Homopropargylglycine


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Human Annexin V with Incorporated Methionine Analogue Homopropargylglycine within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1321 b:71.6 occ:1.00 OE2 A:GLU72 2.5 68.7 1.0 O A:GLY30 2.7 79.5 1.0 OE1 A:GLU72 3.1 67.6 1.0 CD A:GLU72 3.2 67.7 1.0 O A:HOH2271 3.4 35.4 1.0 O A:HOH2055 3.7 48.2 1.0 O A:GLY32 3.8 77.9 1.0 O A:IZO28 3.8 67.6 1.0 C A:GLY30 3.8 78.5 1.0 N A:GLY30 4.1 75.5 1.0 O3 A:SO41323 4.3 80.9 1.0 N A:GLY32 4.3 79.3 1.0 CA A:GLY30 4.5 77.3 1.0 CG A:GLU72 4.6 67.7 1.0 C A:GLY32 4.7 78.1 1.0 N A:LEU31 4.7 79.1 1.0 C A:LEU31 4.8 79.8 1.0 CA A:LEU31 4.8 79.5 1.0 C A:LYS29 4.8 74.3 1.0 CA A:GLY32 4.9 78.9 1.0 C A:IZO28 5.0 68.2 1.0 O1 A:SO41323 5.0 80.6 1.0

M.Debela, L.Merkel, P.Goettig, N.Budisa. Non-Canonical Amino Acids For Click Chemistry Reactions Incorporated in Human Annexin V To Be Published.