Calcium in PDB 2xrc: Human Complement Factor I
Enzymatic activity of Human Complement Factor I
All present enzymatic activity of Human Complement Factor I:
3.4.21.45;
Protein crystallography data
The structure of Human Complement Factor I, PDB code: 2xrc
was solved by
P.Roversi,
S.Johnson,
S.M.Lea,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
|
Resolution Low / High (Å)
|
79.0 /
2.69
|
|
Space group
|
P 1
|
|
Cell size a, b, c (Å), α, β, γ (°)
|
71.317,
234.721,
40.300,
89.98,
90.18,
90.03
|
|
R / Rfree (%)
|
19.959 /
23.821
|
Calcium Binding Sites:
The binding sites of Calcium atom in the Human Complement Factor I
(pdb code 2xrc). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total 8 binding sites of Calcium where determined in the
Human Complement Factor I, PDB code: 2xrc:
Jump to Calcium binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
Calcium binding site 1 out
of 8 in 2xrc
Go back to
Calcium Binding Sites List in 2xrc
Calcium binding site 1 out
of 8 in the Human Complement Factor I
 Mono view
 Stereo pair view
|
|
A full contact list of Calcium with other atoms in the Ca binding
site number 1 of Human Complement Factor I within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Ca600
b:33.9
occ:1.00
|
OD2
|
A:ASP265
|
2.1
|
42.0
|
1.0
|
|
O
|
A:TYR258
|
2.1
|
42.3
|
1.0
|
|
OD1
|
A:ASN261
|
2.3
|
46.7
|
1.0
|
|
O
|
A:GLU263
|
2.3
|
36.1
|
1.0
|
|
OD2
|
A:ASP271
|
2.5
|
41.1
|
1.0
|
|
OE1
|
A:GLU272
|
2.7
|
39.5
|
1.0
|
|
CG
|
A:ASP265
|
3.2
|
40.7
|
1.0
|
|
CG
|
A:ASN261
|
3.3
|
44.6
|
1.0
|
|
C
|
A:TYR258
|
3.3
|
44.6
|
1.0
|
|
C
|
A:GLU263
|
3.5
|
37.9
|
1.0
|
|
CG
|
A:ASP271
|
3.5
|
41.3
|
1.0
|
|
CD
|
A:GLU272
|
3.7
|
41.5
|
1.0
|
|
ND2
|
A:ASN261
|
3.8
|
42.0
|
1.0
|
|
CA
|
A:TYR258
|
3.9
|
44.0
|
1.0
|
|
CB
|
A:ASP265
|
4.0
|
39.2
|
1.0
|
|
CB
|
A:TYR258
|
4.0
|
44.2
|
1.0
|
|
N
|
A:ASP265
|
4.0
|
36.5
|
1.0
|
|
CG
|
A:GLU272
|
4.1
|
40.6
|
1.0
|
|
OD1
|
A:ASP265
|
4.1
|
42.0
|
1.0
|
|
N
|
A:GLU263
|
4.2
|
40.0
|
1.0
|
|
CA
|
A:GLU263
|
4.2
|
38.8
|
1.0
|
|
OD1
|
A:ASP271
|
4.3
|
39.7
|
1.0
|
|
CB
|
A:GLU263
|
4.3
|
39.7
|
1.0
|
|
N
|
A:ASN261
|
4.4
|
44.7
|
1.0
|
|
N
|
A:GLN259
|
4.4
|
43.2
|
1.0
|
|
CB
|
A:ASP271
|
4.4
|
41.8
|
1.0
|
|
CB
|
A:ASN261
|
4.5
|
42.6
|
1.0
|
|
N
|
A:VAL264
|
4.6
|
35.8
|
1.0
|
|
CA
|
A:ASP265
|
4.6
|
38.1
|
1.0
|
|
OE2
|
A:GLU272
|
4.7
|
44.2
|
1.0
|
|
CG
|
A:TYR258
|
4.7
|
44.4
|
1.0
|
|
N
|
A:CYS260
|
4.7
|
44.8
|
1.0
|
|
CA
|
A:GLN259
|
4.7
|
42.2
|
1.0
|
|
C
|
A:VAL264
|
4.8
|
36.2
|
1.0
|
|
CA
|
A:VAL264
|
4.8
|
36.4
|
1.0
|
|
CA
|
A:ASN261
|
4.9
|
42.3
|
1.0
|
|
CD2
|
A:TYR258
|
4.9
|
44.2
|
1.0
|
|
C
|
A:GLN259
|
4.9
|
42.0
|
1.0
|
|
Calcium binding site 2 out
of 8 in 2xrc
Go back to
Calcium Binding Sites List in 2xrc
Calcium binding site 2 out
of 8 in the Human Complement Factor I
 Mono view
 Stereo pair view
|
|
A full contact list of Calcium with other atoms in the Ca binding
site number 2 of Human Complement Factor I within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Ca601
b:43.1
occ:1.00
|
O
|
A:LYS221
|
2.3
|
58.1
|
1.0
|
|
OE2
|
A:GLU235
|
2.3
|
41.3
|
1.0
|
|
OD1
|
A:ASP234
|
2.4
|
40.9
|
1.0
|
|
OD1
|
A:ASP224
|
2.5
|
58.1
|
1.0
|
|
O
|
A:ILE226
|
2.5
|
49.0
|
1.0
|
|
OD2
|
A:ASP228
|
2.6
|
45.9
|
1.0
|
|
CD
|
A:GLU235
|
3.3
|
41.4
|
1.0
|
|
CG
|
A:ASP224
|
3.4
|
58.0
|
1.0
|
|
CG
|
A:ASP234
|
3.5
|
41.7
|
1.0
|
|
C
|
A:LYS221
|
3.5
|
60.4
|
1.0
|
|
C
|
A:ILE226
|
3.6
|
47.8
|
1.0
|
|
CG
|
A:ASP228
|
3.7
|
45.6
|
1.0
|
|
OD2
|
A:ASP224
|
3.7
|
60.6
|
1.0
|
|
OE1
|
A:GLU235
|
4.0
|
42.9
|
1.0
|
|
CB
|
A:ASP234
|
4.1
|
41.6
|
1.0
|
|
N
|
A:ASP224
|
4.1
|
56.9
|
1.0
|
|
N
|
A:ILE226
|
4.2
|
52.2
|
1.0
|
|
N
|
A:ASP228
|
4.2
|
43.7
|
1.0
|
|
N
|
A:CYS223
|
4.2
|
57.7
|
1.0
|
|
CB
|
A:ASP228
|
4.2
|
44.7
|
1.0
|
|
CA
|
A:ILE226
|
4.3
|
48.6
|
1.0
|
|
CB
|
A:ILE226
|
4.3
|
48.9
|
1.0
|
|
N
|
A:ALA222
|
4.3
|
58.1
|
1.0
|
|
CG
|
A:GLU235
|
4.3
|
39.3
|
1.0
|
|
CA
|
A:ALA222
|
4.4
|
57.7
|
1.0
|
|
OD2
|
A:ASP234
|
4.4
|
41.4
|
1.0
|
|
CA
|
A:LYS221
|
4.4
|
63.0
|
1.0
|
|
O
|
A:ASP234
|
4.5
|
43.9
|
1.0
|
|
C
|
A:ALA222
|
4.5
|
56.4
|
1.0
|
|
CB
|
A:LYS221
|
4.5
|
62.1
|
1.0
|
|
CB
|
A:ASP224
|
4.6
|
56.5
|
1.0
|
|
OD1
|
A:ASP228
|
4.7
|
45.0
|
1.0
|
|
N
|
A:ASN227
|
4.7
|
46.7
|
1.0
|
|
CA
|
A:ASP224
|
4.8
|
55.4
|
1.0
|
|
N
|
A:GLY225
|
4.9
|
55.0
|
1.0
|
|
CA
|
A:ASP228
|
4.9
|
44.2
|
1.0
|
|
C
|
A:ASP234
|
4.9
|
40.9
|
1.0
|
|
CA
|
A:ASN227
|
5.0
|
44.8
|
1.0
|
|
CA
|
A:CYS223
|
5.0
|
58.9
|
1.0
|
|
Calcium binding site 3 out
of 8 in 2xrc
Go back to
Calcium Binding Sites List in 2xrc
Calcium binding site 3 out
of 8 in the Human Complement Factor I
 Mono view
 Stereo pair view
|
|
A full contact list of Calcium with other atoms in the Ca binding
site number 3 of Human Complement Factor I within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Ca600
b:58.7
occ:1.00
|
O
|
B:TYR258
|
2.2
|
46.4
|
1.0
|
|
OD2
|
B:ASP271
|
2.4
|
41.5
|
1.0
|
|
O
|
B:GLU263
|
2.5
|
38.4
|
1.0
|
|
OE1
|
B:GLU272
|
2.5
|
34.8
|
1.0
|
|
OD1
|
B:ASN261
|
2.6
|
37.8
|
1.0
|
|
CG
|
B:ASP271
|
3.3
|
41.7
|
1.0
|
|
C
|
B:TYR258
|
3.4
|
44.8
|
1.0
|
|
OD2
|
B:ASP265
|
3.4
|
38.0
|
1.0
|
|
CD
|
B:GLU272
|
3.5
|
34.9
|
1.0
|
|
CG
|
B:ASN261
|
3.5
|
36.6
|
1.0
|
|
CG
|
B:ASP265
|
3.6
|
39.4
|
1.0
|
|
C
|
B:GLU263
|
3.7
|
39.7
|
1.0
|
|
OD1
|
B:ASP265
|
3.7
|
40.9
|
1.0
|
|
OD1
|
B:ASP271
|
3.8
|
44.5
|
1.0
|
|
CG
|
B:GLU272
|
3.9
|
34.6
|
1.0
|
|
N
|
B:ASP265
|
4.2
|
39.8
|
1.0
|
|
N
|
B:ASN261
|
4.2
|
36.1
|
1.0
|
|
ND2
|
B:ASN261
|
4.2
|
34.6
|
1.0
|
|
N
|
B:GLN259
|
4.3
|
41.7
|
1.0
|
|
CA
|
B:TYR258
|
4.3
|
45.9
|
1.0
|
|
CB
|
B:TYR258
|
4.3
|
45.5
|
1.0
|
|
CB
|
B:ASP271
|
4.4
|
40.4
|
1.0
|
|
CA
|
B:GLN259
|
4.4
|
39.1
|
1.0
|
|
O
|
B:ASP271
|
4.4
|
39.0
|
1.0
|
|
CA
|
B:VAL264
|
4.4
|
39.7
|
1.0
|
|
CB
|
B:ASP265
|
4.5
|
39.0
|
1.0
|
|
OE2
|
B:GLU272
|
4.5
|
35.2
|
1.0
|
|
N
|
B:CYS260
|
4.5
|
37.5
|
1.0
|
|
N
|
B:VAL264
|
4.5
|
40.0
|
1.0
|
|
CB
|
B:ASN261
|
4.5
|
36.6
|
1.0
|
|
C
|
B:GLN259
|
4.6
|
37.7
|
1.0
|
|
C
|
B:VAL264
|
4.7
|
39.9
|
1.0
|
|
CA
|
B:GLU263
|
4.7
|
38.9
|
1.0
|
|
N
|
B:GLU263
|
4.7
|
38.9
|
1.0
|
|
C
|
B:ASP271
|
4.8
|
37.8
|
1.0
|
|
CA
|
B:ASN261
|
4.8
|
36.7
|
1.0
|
|
CA
|
B:ASP265
|
5.0
|
39.0
|
1.0
|
|
N
|
B:GLY262
|
5.0
|
37.0
|
1.0
|
|
Calcium binding site 4 out
of 8 in 2xrc
Go back to
Calcium Binding Sites List in 2xrc
Calcium binding site 4 out
of 8 in the Human Complement Factor I
 Mono view
 Stereo pair view
|
|
A full contact list of Calcium with other atoms in the Ca binding
site number 4 of Human Complement Factor I within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Ca601
b:60.5
occ:1.00
|
OE2
|
B:GLU235
|
2.1
|
45.2
|
1.0
|
|
OD2
|
B:ASP228
|
2.2
|
46.4
|
1.0
|
|
O
|
B:ILE226
|
2.3
|
44.4
|
1.0
|
|
OD1
|
B:ASP224
|
2.4
|
60.3
|
1.0
|
|
OD1
|
B:ASP234
|
2.4
|
57.4
|
1.0
|
|
O
|
B:LYS221
|
2.8
|
54.5
|
1.0
|
|
CD
|
B:GLU235
|
3.3
|
46.6
|
1.0
|
|
CG
|
B:ASP228
|
3.3
|
47.0
|
1.0
|
|
CG
|
B:ASP224
|
3.3
|
61.7
|
1.0
|
|
C
|
B:ILE226
|
3.4
|
44.9
|
1.0
|
|
CG
|
B:ASP234
|
3.4
|
54.3
|
1.0
|
|
OD2
|
B:ASP224
|
3.8
|
66.5
|
1.0
|
|
CB
|
B:ASP228
|
3.8
|
46.9
|
1.0
|
|
C
|
B:LYS221
|
3.8
|
56.5
|
1.0
|
|
N
|
B:ASP228
|
3.9
|
45.5
|
1.0
|
|
N
|
B:ILE226
|
3.9
|
51.7
|
1.0
|
|
CA
|
B:ILE226
|
4.0
|
46.1
|
1.0
|
|
CB
|
B:ILE226
|
4.0
|
44.2
|
1.0
|
|
CG
|
B:GLU235
|
4.1
|
46.1
|
1.0
|
|
OE1
|
B:GLU235
|
4.1
|
46.6
|
1.0
|
|
CB
|
B:ASP234
|
4.2
|
52.9
|
1.0
|
|
OD2
|
B:ASP234
|
4.2
|
54.7
|
1.0
|
|
N
|
B:ASP224
|
4.3
|
55.7
|
1.0
|
|
OD1
|
B:ASP228
|
4.3
|
48.2
|
1.0
|
|
CA
|
B:ALA222
|
4.5
|
56.1
|
1.0
|
|
CA
|
B:ASP228
|
4.5
|
45.9
|
1.0
|
|
CB
|
B:ASP224
|
4.5
|
59.2
|
1.0
|
|
N
|
B:ASN227
|
4.5
|
44.7
|
1.0
|
|
N
|
B:ALA222
|
4.6
|
55.5
|
1.0
|
|
N
|
B:CYS223
|
4.6
|
58.7
|
1.0
|
|
CB
|
B:LYS221
|
4.6
|
52.0
|
1.0
|
|
C
|
B:ALA222
|
4.7
|
58.4
|
1.0
|
|
O
|
B:ASP234
|
4.7
|
50.6
|
1.0
|
|
CA
|
B:LYS221
|
4.8
|
55.8
|
1.0
|
|
CA
|
B:ASP224
|
4.8
|
56.5
|
1.0
|
|
N
|
B:GLY225
|
4.8
|
54.4
|
1.0
|
|
C
|
B:ASN227
|
4.8
|
44.6
|
1.0
|
|
CA
|
B:ASN227
|
4.9
|
44.6
|
1.0
|
|
CG1
|
B:ILE226
|
5.0
|
43.1
|
1.0
|
|
CG2
|
B:ILE226
|
5.0
|
43.8
|
1.0
|
|
Calcium binding site 5 out
of 8 in 2xrc
Go back to
Calcium Binding Sites List in 2xrc
Calcium binding site 5 out
of 8 in the Human Complement Factor I
 Mono view
 Stereo pair view
|
|
A full contact list of Calcium with other atoms in the Ca binding
site number 5 of Human Complement Factor I within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Ca600
b:41.9
occ:1.00
|
O
|
C:GLU263
|
2.1
|
34.7
|
1.0
|
|
O
|
C:TYR258
|
2.4
|
42.0
|
1.0
|
|
OD1
|
C:ASN261
|
2.4
|
44.4
|
1.0
|
|
OD2
|
C:ASP271
|
2.5
|
49.9
|
1.0
|
|
OD2
|
C:ASP265
|
2.6
|
30.3
|
1.0
|
|
OE1
|
C:GLU272
|
2.8
|
55.2
|
1.0
|
|
C
|
C:GLU263
|
3.3
|
36.1
|
1.0
|
|
C
|
C:TYR258
|
3.5
|
44.5
|
1.0
|
|
CG
|
C:ASN261
|
3.5
|
45.1
|
1.0
|
|
CG
|
C:ASP265
|
3.5
|
29.4
|
1.0
|
|
CG
|
C:ASP271
|
3.6
|
51.6
|
1.0
|
|
CD
|
C:GLU272
|
3.8
|
55.4
|
1.0
|
|
CG
|
C:GLU272
|
4.1
|
53.2
|
1.0
|
|
N
|
C:ASP265
|
4.1
|
30.0
|
1.0
|
|
N
|
C:GLU263
|
4.1
|
42.0
|
1.0
|
|
CA
|
C:GLU263
|
4.1
|
39.0
|
1.0
|
|
ND2
|
C:ASN261
|
4.2
|
44.5
|
1.0
|
|
N
|
C:ASN261
|
4.2
|
44.6
|
1.0
|
|
OD1
|
C:ASP265
|
4.2
|
27.3
|
1.0
|
|
N
|
C:CYS260
|
4.3
|
41.8
|
1.0
|
|
CB
|
C:ASP271
|
4.3
|
50.5
|
1.0
|
|
N
|
C:VAL264
|
4.3
|
32.4
|
1.0
|
|
N
|
C:GLN259
|
4.4
|
42.9
|
1.0
|
|
CA
|
C:TYR258
|
4.4
|
45.5
|
1.0
|
|
CA
|
C:GLN259
|
4.4
|
39.9
|
1.0
|
|
C
|
C:GLN259
|
4.4
|
39.0
|
1.0
|
|
CB
|
C:GLU263
|
4.4
|
39.8
|
1.0
|
|
CB
|
C:ASP265
|
4.4
|
29.2
|
1.0
|
|
CA
|
C:VAL264
|
4.5
|
30.9
|
1.0
|
|
OD1
|
C:ASP271
|
4.5
|
57.0
|
1.0
|
|
CB
|
C:ASN261
|
4.7
|
44.6
|
1.0
|
|
C
|
C:VAL264
|
4.8
|
30.4
|
1.0
|
|
CB
|
C:TYR258
|
4.8
|
46.9
|
1.0
|
|
CA
|
C:ASN261
|
4.8
|
44.7
|
1.0
|
|
O
|
C:ASP271
|
4.9
|
52.0
|
1.0
|
|
CA
|
C:ASP265
|
4.9
|
29.9
|
1.0
|
|
C
|
C:ASN261
|
4.9
|
45.9
|
1.0
|
|
OE2
|
C:GLU272
|
5.0
|
54.8
|
1.0
|
|
N
|
C:GLY262
|
5.0
|
45.1
|
1.0
|
|
CA
|
C:CYS260
|
5.0
|
44.3
|
1.0
|
|
Calcium binding site 6 out
of 8 in 2xrc
Go back to
Calcium Binding Sites List in 2xrc
Calcium binding site 6 out
of 8 in the Human Complement Factor I
 Mono view
 Stereo pair view
|
|
A full contact list of Calcium with other atoms in the Ca binding
site number 6 of Human Complement Factor I within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Ca601
b:37.2
occ:1.00
|
OD1
|
C:ASP224
|
2.3
|
38.6
|
1.0
|
|
OD1
|
C:ASP234
|
2.3
|
43.7
|
1.0
|
|
O
|
C:LYS221
|
2.3
|
46.7
|
1.0
|
|
OD2
|
C:ASP228
|
2.3
|
36.8
|
1.0
|
|
O
|
C:ILE226
|
2.3
|
32.4
|
1.0
|
|
OE2
|
C:GLU235
|
2.6
|
43.0
|
1.0
|
|
CD
|
C:GLU235
|
3.2
|
43.1
|
1.0
|
|
CG
|
C:ASP228
|
3.5
|
37.0
|
1.0
|
|
CG
|
C:ASP234
|
3.5
|
42.9
|
1.0
|
|
C
|
C:LYS221
|
3.5
|
48.1
|
1.0
|
|
CG
|
C:ASP224
|
3.5
|
39.4
|
1.0
|
|
C
|
C:ILE226
|
3.6
|
32.5
|
1.0
|
|
CG
|
C:GLU235
|
3.7
|
42.0
|
1.0
|
|
CB
|
C:ASP228
|
3.9
|
37.3
|
1.0
|
|
OE1
|
C:GLU235
|
4.0
|
42.3
|
1.0
|
|
N
|
C:ASP228
|
4.1
|
36.7
|
1.0
|
|
OD2
|
C:ASP234
|
4.1
|
43.3
|
1.0
|
|
N
|
C:ASP224
|
4.2
|
37.6
|
1.0
|
|
OD2
|
C:ASP224
|
4.3
|
40.3
|
1.0
|
|
CA
|
C:LYS221
|
4.4
|
50.6
|
1.0
|
|
N
|
C:ILE226
|
4.4
|
34.3
|
1.0
|
|
CA
|
C:ILE226
|
4.5
|
32.4
|
1.0
|
|
N
|
C:ASN227
|
4.5
|
33.0
|
1.0
|
|
CB
|
C:ASP224
|
4.5
|
38.6
|
1.0
|
|
OD1
|
C:ASP228
|
4.5
|
36.0
|
1.0
|
|
N
|
C:ALA222
|
4.5
|
45.6
|
1.0
|
|
CB
|
C:ASP234
|
4.5
|
42.1
|
1.0
|
|
CB
|
C:LYS221
|
4.6
|
49.7
|
1.0
|
|
N
|
C:CYS223
|
4.6
|
44.0
|
1.0
|
|
CA
|
C:ASN227
|
4.6
|
33.9
|
1.0
|
|
C
|
C:ASN227
|
4.6
|
35.9
|
1.0
|
|
CA
|
C:ALA222
|
4.6
|
45.0
|
1.0
|
|
CA
|
C:ASP228
|
4.7
|
37.3
|
1.0
|
|
CA
|
C:ASP224
|
4.7
|
37.3
|
1.0
|
|
N
|
C:GLY225
|
4.7
|
34.8
|
1.0
|
|
C
|
C:ASP224
|
4.8
|
35.5
|
1.0
|
|
C
|
C:ALA222
|
4.8
|
45.0
|
1.0
|
|
C
|
C:GLY225
|
4.9
|
35.4
|
1.0
|
|
CB
|
C:ILE226
|
4.9
|
31.9
|
1.0
|
|
O
|
C:ASP234
|
5.0
|
46.7
|
1.0
|
|
Calcium binding site 7 out
of 8 in 2xrc
Go back to
Calcium Binding Sites List in 2xrc
Calcium binding site 7 out
of 8 in the Human Complement Factor I
 Mono view
 Stereo pair view
|
|
A full contact list of Calcium with other atoms in the Ca binding
site number 7 of Human Complement Factor I within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Ca600
b:45.5
occ:1.00
|
O
|
D:GLU263
|
2.3
|
36.8
|
1.0
|
|
O
|
D:TYR258
|
2.3
|
44.1
|
1.0
|
|
OD2
|
D:ASP271
|
2.4
|
37.6
|
1.0
|
|
OD1
|
D:ASN261
|
2.4
|
38.5
|
1.0
|
|
OE1
|
D:GLU272
|
2.5
|
40.0
|
1.0
|
|
OD2
|
D:ASP265
|
2.8
|
31.6
|
1.0
|
|
CD
|
D:GLU272
|
3.3
|
40.8
|
1.0
|
|
CG
|
D:ASP265
|
3.5
|
32.8
|
1.0
|
|
CG
|
D:ASN261
|
3.5
|
38.4
|
1.0
|
|
C
|
D:GLU263
|
3.5
|
37.3
|
1.0
|
|
C
|
D:TYR258
|
3.5
|
45.7
|
1.0
|
|
CG
|
D:ASP271
|
3.6
|
38.0
|
1.0
|
|
OD1
|
D:ASP265
|
3.8
|
32.9
|
1.0
|
|
CG
|
D:GLU272
|
3.8
|
39.5
|
1.0
|
|
ND2
|
D:ASN261
|
4.1
|
37.9
|
1.0
|
|
O
|
D:ASP271
|
4.1
|
41.1
|
1.0
|
|
OE2
|
D:GLU272
|
4.3
|
42.4
|
1.0
|
|
N
|
D:ASN261
|
4.3
|
40.4
|
1.0
|
|
N
|
D:CYS260
|
4.3
|
41.6
|
1.0
|
|
N
|
D:ASP265
|
4.3
|
33.8
|
1.0
|
|
CA
|
D:GLN259
|
4.4
|
42.3
|
1.0
|
|
N
|
D:GLN259
|
4.4
|
44.3
|
1.0
|
|
N
|
D:VAL264
|
4.4
|
35.6
|
1.0
|
|
CA
|
D:VAL264
|
4.4
|
34.4
|
1.0
|
|
CB
|
D:ASP271
|
4.5
|
39.2
|
1.0
|
|
CA
|
D:GLU263
|
4.5
|
37.7
|
1.0
|
|
N
|
D:GLU263
|
4.5
|
39.8
|
1.0
|
|
CA
|
D:TYR258
|
4.5
|
45.3
|
1.0
|
|
OD1
|
D:ASP271
|
4.5
|
39.5
|
1.0
|
|
C
|
D:GLN259
|
4.6
|
41.0
|
1.0
|
|
CB
|
D:ASP265
|
4.6
|
32.8
|
1.0
|
|
C
|
D:VAL264
|
4.6
|
34.8
|
1.0
|
|
CB
|
D:TYR258
|
4.6
|
44.2
|
1.0
|
|
CB
|
D:ASN261
|
4.7
|
38.4
|
1.0
|
|
C
|
D:ASP271
|
4.7
|
39.5
|
1.0
|
|
CB
|
D:GLU263
|
4.8
|
37.5
|
1.0
|
|
CA
|
D:ASN261
|
4.9
|
39.0
|
1.0
|
|
N
|
D:GLY262
|
5.0
|
38.5
|
1.0
|
|
Calcium binding site 8 out
of 8 in 2xrc
Go back to
Calcium Binding Sites List in 2xrc
Calcium binding site 8 out
of 8 in the Human Complement Factor I
 Mono view
 Stereo pair view
|
|
A full contact list of Calcium with other atoms in the Ca binding
site number 8 of Human Complement Factor I within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Ca601
b:61.4
occ:1.00
|
OD1
|
D:ASP234
|
2.3
|
48.8
|
1.0
|
|
OD2
|
D:ASP228
|
2.4
|
44.6
|
1.0
|
|
O
|
D:ILE226
|
2.4
|
40.2
|
1.0
|
|
OE2
|
D:GLU235
|
2.5
|
61.9
|
1.0
|
|
O
|
D:LYS221
|
2.6
|
55.8
|
1.0
|
|
OD1
|
D:ASP224
|
2.6
|
38.8
|
1.0
|
|
CG
|
D:ASP228
|
3.2
|
43.3
|
1.0
|
|
CD
|
D:GLU235
|
3.4
|
60.0
|
1.0
|
|
CG
|
D:ASP234
|
3.4
|
48.7
|
1.0
|
|
CG
|
D:ASP224
|
3.6
|
41.2
|
1.0
|
|
C
|
D:LYS221
|
3.6
|
54.4
|
1.0
|
|
CG
|
D:GLU235
|
3.6
|
57.6
|
1.0
|
|
C
|
D:ILE226
|
3.6
|
38.2
|
1.0
|
|
CB
|
D:ASP228
|
3.7
|
42.0
|
1.0
|
|
N
|
D:ASP228
|
3.7
|
39.0
|
1.0
|
|
OD2
|
D:ASP224
|
4.1
|
42.4
|
1.0
|
|
OD1
|
D:ASP228
|
4.1
|
46.6
|
1.0
|
|
OD2
|
D:ASP234
|
4.2
|
50.6
|
1.0
|
|
CA
|
D:ASP228
|
4.4
|
40.0
|
1.0
|
|
CA
|
D:ALA222
|
4.4
|
51.1
|
1.0
|
|
N
|
D:ALA222
|
4.4
|
52.5
|
1.0
|
|
CB
|
D:ASP234
|
4.4
|
47.5
|
1.0
|
|
OE1
|
D:GLU235
|
4.4
|
63.5
|
1.0
|
|
N
|
D:ASP224
|
4.5
|
44.2
|
1.0
|
|
N
|
D:CYS223
|
4.5
|
49.8
|
1.0
|
|
CA
|
D:LYS221
|
4.5
|
53.7
|
1.0
|
|
N
|
D:ASN227
|
4.5
|
37.2
|
1.0
|
|
CA
|
D:ASN227
|
4.6
|
37.2
|
1.0
|
|
N
|
D:ILE226
|
4.6
|
38.0
|
1.0
|
|
CA
|
D:ILE226
|
4.6
|
37.2
|
1.0
|
|
C
|
D:ASN227
|
4.6
|
38.1
|
1.0
|
|
CB
|
D:LYS221
|
4.6
|
51.8
|
1.0
|
|
C
|
D:ALA222
|
4.7
|
50.2
|
1.0
|
|
CB
|
D:ASP224
|
4.7
|
41.7
|
1.0
|
|
CB
|
D:ILE226
|
4.9
|
35.8
|
1.0
|
|
Reference:
P.Roversi,
S.Johnson,
J.J.Caesar,
F.Mclean,
K.J.Leath,
S.A.Tsiftsoglou,
B.P.Morgan,
C.L.Harris,
R.B.Sim,
S.M.Lea.
Structural Basis For Complement Factor I Control and Its Disease-Associated Sequence Polymorphisms. Proc.Natl.Acad.Sci.Usa V. 108 12839 2011.
ISSN: ISSN 0027-8424
PubMed: 21768352
DOI: 10.1073/PNAS.1102167108
Page generated: Fri Jul 12 19:14:31 2024
|
