Calcium in PDB 2xtj: The Crystal Structure of PCSK9 in Complex with 1D05 Fab

The structure of The Crystal Structure of PCSK9 in Complex with 1D05 Fab, PDB code: 2xtj was solved by S.Di Marco, C.Volpari, A.Carfi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.00 / 2.70
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	66.589, 67.834, 250.860, 90.00, 90.00, 90.00
R / Rfree (%)	20 / 25.9

The binding sites of Calcium atom in the The Crystal Structure of PCSK9 in Complex with 1D05 Fab (pdb code 2xtj). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the The Crystal Structure of PCSK9 in Complex with 1D05 Fab, PDB code: 2xtj:

Calcium binding site 1 out of 1 in the The Crystal Structure of PCSK9 in Complex with 1D05 Fab


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of The Crystal Structure of PCSK9 in Complex with 1D05 Fab within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1423 b:62.8 occ:1.00 O A:VAL333 2.3 20.3 1.0 OD2 A:ASP360 2.3 24.5 1.0 O A:ALA330 2.7 17.4 1.0 OG1 A:THR335 2.9 18.8 1.0 CG A:ASP360 3.2 24.1 1.0 OD1 A:ASP360 3.4 24.7 1.0 C A:VAL333 3.5 20.2 1.0 CB A:THR335 3.7 17.9 1.0 C A:ALA330 3.7 17.0 1.0 NH2 A:ARG412 3.7 32.8 1.0 CA A:PRO331 3.8 18.6 1.0 N A:THR335 3.8 18.6 1.0 O A:CYS358 4.0 20.7 1.0 N A:PRO331 4.2 17.8 1.0 O A:HOH2044 4.2 25.8 1.0 C A:PRO331 4.2 19.1 1.0 N A:VAL333 4.2 20.3 1.0 O A:ALA328 4.3 15.0 1.0 CA A:THR335 4.4 18.0 1.0 CA A:ILE334 4.4 19.6 1.0 N A:ILE334 4.4 20.0 1.0 CA A:VAL333 4.4 20.1 1.0 N A:GLU332 4.4 19.3 1.0 C A:ILE334 4.5 19.2 1.0 CB A:ASP360 4.6 22.7 1.0 CB A:VAL333 4.7 20.2 1.0 O A:PRO331 4.8 20.5 1.0 CA A:ALA330 4.9 16.4 1.0 CG2 A:THR335 4.9 17.4 1.0

Y.G.Ni, S.Di Marco, J.H.Condra, L.B.Peterson, W.Wang, F.Wang, S.Pandit, H.A.Hammond, R.Rosa, R.T.Cummings, D.D.Wood, X.Liu, M.J.Bottomley, X.Shen, R.M.Cubbon, S.P.Wang, D.G.Johns, C.Volpari, L.Hamuro, J.Chin, L.Huang, J.Z.Zhao, S.Vitelli, P.Haytko, D.Wisniewski, L.J.Mitnaul, C.P.Sparrow, B.Hubbard, A.Carfi, A.Sitlani. A PCSK9-Binding Antibody That Structurally Mimics the Egf(A) Domain of Ldl-Receptor Reduces Ldl Cholesterol in Vivo. J.Lipid Res. V. 52 78 2011.
ISSN: ISSN 0022-2275
PubMed: 20959675
DOI: 10.1194/JLR.M011445