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Calcium in PDB 3c16: Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine-5'-Triphosphate and Ca

Enzymatic activity of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine-5'-Triphosphate and Ca

All present enzymatic activity of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine-5'-Triphosphate and Ca:
4.6.1.1;

Protein crystallography data

The structure of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine-5'-Triphosphate and Ca, PDB code: 3c16 was solved by T.-C.Mou, S.R.Sprang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 15.00 / 2.87
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 118.331, 133.527, 70.703, 90.00, 90.00, 90.00
R / Rfree (%) 24.9 / 29.9

Other elements in 3c16:

The structure of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine-5'-Triphosphate and Ca also contains other interesting chemical elements:

Magnesium (Mg) 1 atom
Chlorine (Cl) 1 atom

Calcium Binding Sites:

The binding sites of Calcium atom in the Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine-5'-Triphosphate and Ca (pdb code 3c16). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine-5'-Triphosphate and Ca, PDB code: 3c16:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in 3c16

Go back to Calcium Binding Sites List in 3c16
Calcium binding site 1 out of 2 in the Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine-5'-Triphosphate and Ca


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine-5'-Triphosphate and Ca within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca29

b:49.4
occ:1.00
 O1B A:ATP1 2.1 49.6 1.0
OD2 A:ASP440 2.2 64.7 1.0
O3A A:ATP1 2.3 51.5 1.0
OD2 A:ASP396 2.5 79.8 1.0
PB A:ATP1 2.7 51.1 1.0
CA A:CA30 2.8 38.4 1.0
O3G A:ATP1 3.0 31.0 1.0
O A:ILE397 3.1 50.6 1.0
CG A:ASP440 3.2 62.0 1.0
O3B A:ATP1 3.5 42.6 1.0
PA A:ATP1 3.5 58.0 1.0
O1A A:ATP1 3.5 54.3 1.0
CG A:ASP396 3.5 76.5 1.0
OD1 A:ASP440 3.6 61.5 1.0
PG A:ATP1 3.6 35.3 1.0
OD1 A:ASP396 3.9 82.5 1.0
O2B A:ATP1 4.0 38.9 1.0
O1G A:ATP1 4.1 31.4 1.0
CB A:PHE400 4.1 73.1 1.0
O5' A:ATP1 4.1 56.7 1.0
C A:ILE397 4.2 56.0 1.0
N A:ILE397 4.3 53.2 1.0
O A:HOH5 4.4 38.7 1.0
CB A:ASP440 4.5 55.5 1.0
O2A A:ATP1 4.7 56.6 1.0
CA A:ILE397 4.7 51.0 1.0
CG A:PHE400 4.8 79.7 1.0
CB A:ASP396 4.8 65.4 1.0
CD2 A:PHE400 5.0 79.3 1.0

Calcium binding site 2 out of 2 in 3c16

Go back to Calcium Binding Sites List in 3c16
Calcium binding site 2 out of 2 in the Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine-5'-Triphosphate and Ca


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine-5'-Triphosphate and Ca within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca30

b:38.4
occ:1.00
 O1A A:ATP1 2.6 54.3 1.0
OD2 A:ASP396 2.7 79.8 1.0
CA A:CA29 2.8 49.4 1.0
O A:HOH2 2.9 20.4 1.0
OD1 A:ASP440 3.0 61.5 1.0
OD1 A:ASP396 3.1 82.5 1.0
CG A:ASP396 3.2 76.5 1.0
O5' A:ATP1 3.3 56.7 1.0
PA A:ATP1 3.3 58.0 1.0
OD2 A:ASP440 3.4 64.7 1.0
O3A A:ATP1 3.4 51.5 1.0
CG A:ASP440 3.6 62.0 1.0
O3G A:ATP1 3.7 31.0 1.0
O A:HOH4 3.8 18.6 1.0
C3' A:ATP1 3.9 43.8 1.0
O3' A:ATP1 4.0 51.2 1.0
C5' A:ATP1 4.6 52.4 1.0
CB A:ASP396 4.6 65.4 1.0
O A:HOH6 4.6 64.0 1.0
PB A:ATP1 4.6 51.1 1.0
O1B A:ATP1 4.7 49.6 1.0
O2A A:ATP1 4.8 56.6 1.0
O3B A:ATP1 4.9 42.6 1.0
C4' A:ATP1 4.9 48.9 1.0
PG A:ATP1 4.9 35.3 1.0
C2' A:ATP1 4.9 50.4 1.0

Reference:

T.C.Mou, N.Masada, D.M.Cooper, S.R.Sprang. Structural Basis For Inhibition of Mammalian Adenylyl Cyclase By Calcium. Biochemistry V. 48 3387 2009.
ISSN: ISSN 0006-2960
PubMed: 19243146
DOI: 10.1021/BI802122K
Page generated: Sat Jul 13 08:31:36 2024

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