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Calcium in PDB 3eqd: X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Binary Complex with Atp-Gs and MG2P

Enzymatic activity of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Binary Complex with Atp-Gs and MG2P

All present enzymatic activity of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Binary Complex with Atp-Gs and MG2P:
2.7.12.2;

Protein crystallography data

The structure of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Binary Complex with Atp-Gs and MG2P, PDB code: 3eqd was solved by T.O.Fischmann, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.00 / 2.10
Space group P 61 2 2
Cell size a, b, c (Å), α, β, γ (°) 77.010, 77.010, 222.370, 90.00, 90.00, 120.00
R / Rfree (%) n/a / n/a

Other elements in 3eqd:

The structure of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Binary Complex with Atp-Gs and MG2P also contains other interesting chemical elements:

Magnesium (Mg) 1 atom
Sodium (Na) 1 atom

Calcium Binding Sites:

The binding sites of Calcium atom in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Binary Complex with Atp-Gs and MG2P (pdb code 3eqd). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Binary Complex with Atp-Gs and MG2P, PDB code: 3eqd:

Calcium binding site 1 out of 1 in 3eqd

Go back to Calcium Binding Sites List in 3eqd
Calcium binding site 1 out of 1 in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Binary Complex with Atp-Gs and MG2P


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Binary Complex with Atp-Gs and MG2P within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca5

b:50.1
occ:0.50
 O A:HOH500 2.1 55.3 1.0
OD1 A:ASP66 2.2 56.0 1.0
OD2 A:ASP65 2.5 52.3 1.0
CG A:ASP66 3.3 57.4 1.0
CG A:ASP65 3.5 50.4 1.0
OD2 A:ASP66 3.8 67.5 1.0
CB A:ASP65 3.9 45.1 1.0
NA A:NA6 4.3 38.3 1.0
N A:ASP66 4.3 44.6 1.0
O A:HOH514 4.3 46.9 1.0
O A:HOH414 4.4 53.2 1.0
CB A:ASP66 4.5 46.5 1.0
CA A:ASP66 4.5 44.2 1.0
C A:ASP65 4.6 47.6 1.0
OD1 A:ASP65 4.7 49.6 1.0
OD1 A:ASP136 4.8 76.3 1.0
OG A:SER135 4.8 69.7 1.0
O A:HOH441 4.9 47.8 1.0
CA A:ASP65 4.9 43.7 1.0

Reference:

T.O.Fischmann, C.K.Smith, T.W.Mayhood, J.E.Myers, P.Reichert, A.Mannarino, D.Carr, H.Zhu, J.Wong, R.S.Yang, H.V.Le, V.S.Madison. Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors. Biochemistry V. 48 2661 2009.
ISSN: ISSN 0006-2960
PubMed: 19161339
DOI: 10.1021/BI801898E
Page generated: Sat Jul 13 09:32:38 2024

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