Calcium in PDB 3ktu: Structure of Human 8-Oxoguanine Glycosylase 1 Bound to Fluorninated Oxog-Containing Dna

All present enzymatic activity of Structure of Human 8-Oxoguanine Glycosylase 1 Bound to Fluorninated Oxog-Containing Dna:
4.2.99.18;

The structure of Structure of Human 8-Oxoguanine Glycosylase 1 Bound to Fluorninated Oxog-Containing Dna, PDB code: 3ktu was solved by G.L.Verdine, S.M.Lee, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	25.21 / 2.30
Space group	P 65 2 2
Cell size a, b, c (Å), α, β, γ (°)	92.400, 92.400, 212.500, 90.00, 90.00, 120.00
R / Rfree (%)	22.5 / 25.7

The structure of Structure of Human 8-Oxoguanine Glycosylase 1 Bound to Fluorninated Oxog-Containing Dna also contains other interesting chemical elements:

Fluorine

(F)

1 atom

The binding sites of Calcium atom in the Structure of Human 8-Oxoguanine Glycosylase 1 Bound to Fluorninated Oxog-Containing Dna (pdb code 3ktu). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Structure of Human 8-Oxoguanine Glycosylase 1 Bound to Fluorninated Oxog-Containing Dna, PDB code: 3ktu:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Structure of Human 8-Oxoguanine Glycosylase 1 Bound to Fluorninated Oxog-Containing Dna


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structure of Human 8-Oxoguanine Glycosylase 1 Bound to Fluorninated Oxog-Containing Dna within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca2 b:77.5 occ:1.00 O A:CYS241 2.6 50.4 1.0 OP1 C:DC26 2.6 60.2 1.0 O A:LEU243 2.8 52.1 1.0 O A:VAL246 2.8 49.0 1.0 OP2 C:DC26 3.2 61.5 1.0 P C:DC26 3.4 60.9 1.0 C A:CYS241 3.5 51.6 1.0 C A:LEU243 3.8 50.6 1.0 C A:VAL246 3.8 49.2 1.0 O A:ILE242 4.1 52.6 1.0 C A:ILE242 4.1 52.5 1.0 N A:VAL246 4.2 48.7 1.0 CA A:CYS241 4.2 51.4 1.0 N A:LEU243 4.3 50.9 1.0 CA A:VAL246 4.4 47.8 1.0 N A:ILE242 4.5 52.8 1.0 O5' C:DC26 4.5 62.7 1.0 O3' C:DT25 4.6 60.1 1.0 N A:PRO244 4.6 52.6 1.0 CA A:LEU243 4.6 50.1 1.0 CA A:ILE242 4.6 54.0 1.0 N A:GLY245 4.6 52.8 1.0 CB A:VAL246 4.7 47.2 1.0 CA A:PRO244 4.7 52.2 1.0 CB A:CYS241 4.8 52.8 1.0 N A:GLY247 4.8 49.7 1.0

Calcium binding site 2 out of 2 in the Structure of Human 8-Oxoguanine Glycosylase 1 Bound to Fluorninated Oxog-Containing Dna


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Structure of Human 8-Oxoguanine Glycosylase 1 Bound to Fluorninated Oxog-Containing Dna within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca1 b:94.5 occ:1.00 OP1 C:DG24 2.9 77.3 1.0 CG2 A:VAL269 3.6 59.4 1.0 C5' C:DG24 3.6 68.4 1.0 C8 C:DG24 3.8 63.0 1.0 P C:DG24 4.1 76.4 1.0 O5' C:DG24 4.1 74.0 1.0 O C:HOH55 4.2 58.8 1.0 N A:VAL269 4.4 57.6 1.0 C2' C:DG24 4.5 62.4 1.0 N7 C:DG24 4.6 62.7 1.0 C4' C:DG24 4.6 65.1 1.0 N9 C:DG24 4.8 62.5 1.0 C3' C:DG24 4.8 61.6 1.0 O4' C:DG24 4.8 64.9 1.0 CB A:VAL269 4.9 58.9 1.0 CA A:ASP268 4.9 57.3 1.0 OP2 C:DG24 5.0 76.0 1.0

G.L.Verdine, S.M.Lee. Structural Investigation of HOGG1 Bound to A Fluorinated Oxog Analog To Be Published.