Calcium in PDB 3ooy: Crystal Structure of Human Transketolase (Tkt)

All present enzymatic activity of Crystal Structure of Human Transketolase (Tkt):
2.2.1.1;

The structure of Crystal Structure of Human Transketolase (Tkt), PDB code: 3ooy was solved by T.Krojer, E.Krysztofinska, K.Guo, E.Pilka, G.Kochan, A.Chaikuad, M.Vollmar, F.Von Delft, C.Bountra, C.H.Arrowsmith, J.Weigelt, A.Edwards, K.Kavanagh, U.Oppermann, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.48 / 2.05
Space group	P 61
Cell size a, b, c (Å), α, β, γ (°)	117.230, 117.230, 176.803, 90.00, 90.00, 120.00
R / Rfree (%)	19.9 / 23.4

The binding sites of Calcium atom in the Crystal Structure of Human Transketolase (Tkt) (pdb code 3ooy). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Crystal Structure of Human Transketolase (Tkt), PDB code: 3ooy:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Crystal Structure of Human Transketolase (Tkt)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of Human Transketolase (Tkt) within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca621 b:29.8 occ:1.00 OD1 A:ASP155 2.1 12.9 1.0 O12 A:TDP1 2.1 14.4 1.0 O A:LEU187 2.1 12.4 1.0 O22 A:TDP1 2.3 10.5 1.0 OD1 A:ASN185 2.3 12.9 1.0 O A:HOH627 2.3 11.5 1.0 CG A:ASN185 3.1 13.7 1.0 P2 A:TDP1 3.2 12.5 1.0 CG A:ASP155 3.2 13.0 1.0 P1 A:TDP1 3.3 12.0 1.0 C A:LEU187 3.3 13.8 1.0 ND2 A:ASN185 3.4 8.9 1.0 O11 A:TDP1 3.4 13.2 1.0 O23 A:TDP1 3.7 14.9 1.0 N A:ASP155 3.8 13.1 1.0 OD2 A:ASP155 3.8 12.9 1.0 N A:LEU187 4.0 14.5 1.0 N A:GLY156 4.2 13.1 1.0 O5G A:TDP1 4.2 11.8 1.0 O A:ASP183 4.2 13.7 1.0 N A:GLY188 4.2 14.6 1.0 CA A:LEU187 4.3 14.0 1.0 O13 A:TDP1 4.3 11.5 1.0 CB A:ASP155 4.4 14.1 1.0 CA A:GLY188 4.4 14.3 1.0 N A:ASN185 4.5 13.5 1.0 CB A:ASN185 4.5 13.8 1.0 CA A:ASP155 4.5 13.5 1.0 NZ A:LYS244 4.5 11.9 1.0 O21 A:TDP1 4.5 10.2 1.0 C A:ASN185 4.7 13.6 1.0 N A:ARG186 4.7 14.4 1.0 CA A:ASN185 4.7 13.8 1.0 C A:GLY154 4.8 13.5 1.0 CA A:GLY154 4.8 13.4 1.0 CD A:LYS244 4.9 13.8 1.0 C A:ASP155 4.9 13.7 1.0 CE A:LYS244 4.9 12.5 1.0 C A:ARG186 4.9 14.7 1.0

Calcium binding site 2 out of 2 in the Crystal Structure of Human Transketolase (Tkt)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Crystal Structure of Human Transketolase (Tkt) within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca621 b:30.4 occ:1.00 O12 B:TDP1 2.0 13.6 1.0 OD1 B:ASP155 2.1 10.8 1.0 OD1 B:ASN185 2.1 14.5 1.0 O B:LEU187 2.1 15.2 1.0 O22 B:TDP1 2.1 12.6 1.0 O B:HOH627 2.3 10.2 1.0 CG B:ASN185 2.9 15.8 1.0 P2 B:TDP1 3.2 13.5 1.0 ND2 B:ASN185 3.2 12.0 1.0 P1 B:TDP1 3.2 14.7 1.0 CG B:ASP155 3.3 14.4 1.0 C B:LEU187 3.3 15.8 1.0 O11 B:TDP1 3.5 13.5 1.0 O23 B:TDP1 3.6 15.3 1.0 OD2 B:ASP155 3.9 14.2 1.0 N B:ASP155 3.9 14.0 1.0 N B:LEU187 3.9 15.4 1.0 O5G B:TDP1 4.1 14.0 1.0 CA B:LEU187 4.2 15.3 1.0 N B:GLY188 4.2 15.7 1.0 N B:GLY156 4.3 12.9 1.0 O13 B:TDP1 4.3 16.1 1.0 CB B:ASN185 4.3 15.3 1.0 CA B:GLY188 4.4 15.8 1.0 O B:ASP183 4.4 13.5 1.0 NZ B:LYS244 4.4 14.7 1.0 CB B:ASP155 4.4 13.8 1.0 N B:ASN185 4.5 14.7 1.0 CA B:ASP155 4.6 13.5 1.0 O21 B:TDP1 4.6 15.3 1.0 CD B:LYS244 4.6 13.4 1.0 C B:ASN185 4.6 14.3 1.0 CA B:ASN185 4.7 14.8 1.0 N B:ARG186 4.7 14.3 1.0 C B:GLY154 4.9 15.1 1.0 CE B:LYS244 4.9 15.4 1.0 CA B:GLY154 4.9 14.4 1.0 C B:ARG186 4.9 15.2 1.0 CB B:LEU187 4.9 15.7 1.0 C B:ASP155 4.9 13.6 1.0 O B:ASN185 5.0 14.6 1.0

T.Krojer, E.Krysztofinska, K.Guo, E.Pilka, G.Kochan, A.Chaikuad, M.Vollmar, F.Von Delft, C.Bountra, C.H.Arrowsmith, J.Weigelt, A.Edwards, K.Kavanagh, U.Oppermann. Crystal Structure of Human Transketolase (Tkt) To Be Published.