Calcium in PDB 4b3o: Structures of Hiv-1 Rt and Rna-Dna Complex Reveal A Unique Rt Conformation and Substrate Interface

All present enzymatic activity of Structures of Hiv-1 Rt and Rna-Dna Complex Reveal A Unique Rt Conformation and Substrate Interface:
2.7.7.49; 2.7.7.7; 3.1.13.2; 3.1.26.13; 3.4.23.16;

The structure of Structures of Hiv-1 Rt and Rna-Dna Complex Reveal A Unique Rt Conformation and Substrate Interface, PDB code: 4b3o was solved by M.Lapkouski, L.Tian, J.T.Miller, S.F.J.Le Grice, W.Yang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.73 / 3.30
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	164.598, 164.598, 129.030, 90.00, 90.00, 120.00
R / Rfree (%)	27.5 / 29.5

The structure of Structures of Hiv-1 Rt and Rna-Dna Complex Reveal A Unique Rt Conformation and Substrate Interface also contains other interesting chemical elements:

Fluorine	(F)	3 atoms
Chlorine	(Cl)	1 atom

The binding sites of Calcium atom in the Structures of Hiv-1 Rt and Rna-Dna Complex Reveal A Unique Rt Conformation and Substrate Interface (pdb code 4b3o). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Structures of Hiv-1 Rt and Rna-Dna Complex Reveal A Unique Rt Conformation and Substrate Interface, PDB code: 4b3o:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Structures of Hiv-1 Rt and Rna-Dna Complex Reveal A Unique Rt Conformation and Substrate Interface


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structures of Hiv-1 Rt and Rna-Dna Complex Reveal A Unique Rt Conformation and Substrate Interface within 5.0Å range: probe atom residue distance (Å) B Occ D:Ca100 b:65.3 occ:1.00 O4 D:DT19 4.5 75.0 1.0 O6 D:DG18 4.6 84.7 1.0 N7 D:DG18 4.7 76.0 1.0 N4 R:C9 4.9 72.7 1.0 C7 D:DT17 4.9 65.5 1.0

Calcium binding site 2 out of 2 in the Structures of Hiv-1 Rt and Rna-Dna Complex Reveal A Unique Rt Conformation and Substrate Interface


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Structures of Hiv-1 Rt and Rna-Dna Complex Reveal A Unique Rt Conformation and Substrate Interface within 5.0Å range: probe atom residue distance (Å) B Occ R:Ca100 b:86.0 occ:1.00 N7 R:G23 4.4 73.0 1.0 N7 R:G22 4.4 70.4 1.0 O6 R:G23 4.6 75.6 1.0 O6 R:G22 4.8 70.6 1.0 C5 R:G22 5.0 64.6 1.0

M.Lapkouski, L.Tian, J.T.Miller, S.F.J.Le Grice, W.Yang. Complexes of Hiv-1 Rt, Nnrti and Rna/Dna Hybrid Reveal A Structure Compatible with Rna Degradation Nat.Struct.Mol.Biol. V. 20 230 2013.
ISSN: ISSN 1545-9993
PubMed: 23314251
DOI: 10.1038/NSMB.2485