Calcium in PDB 4c29: Crystal Structure of High-Affinity Von Willebrand Factor A1 Domain with Disulfide Mutation

The structure of Crystal Structure of High-Affinity Von Willebrand Factor A1 Domain with Disulfide Mutation, PDB code: 4c29 was solved by M.A.Blenner, X.Dong, T.A.Springer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	41.202 / 2.20
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	41.249, 50.071, 96.869, 90.00, 92.73, 90.00
R / Rfree (%)	18.55 / 23.51

The binding sites of Calcium atom in the Crystal Structure of High-Affinity Von Willebrand Factor A1 Domain with Disulfide Mutation (pdb code 4c29). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 3 binding sites of Calcium where determined in the Crystal Structure of High-Affinity Von Willebrand Factor A1 Domain with Disulfide Mutation, PDB code: 4c29:
Jump to Calcium binding site number: 1; 2; 3;

Calcium binding site 1 out of 3 in the Crystal Structure of High-Affinity Von Willebrand Factor A1 Domain with Disulfide Mutation


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of High-Affinity Von Willebrand Factor A1 Domain with Disulfide Mutation within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca2470 b:63.9 occ:1.00 O A:HOH2022 2.4 44.4 1.0 O A:HOH2014 2.4 47.2 1.0 O A:HOH2013 2.4 46.7 1.0 O A:ARG1287 4.4 25.4 1.0 OE2 A:GLU1292 4.6 46.5 1.0 OE1 A:GLU1292 4.6 29.7 1.0 O A:HOH2011 4.8 42.5 1.0 O A:HOH2079 4.9 46.8 1.0

Calcium binding site 2 out of 3 in the Crystal Structure of High-Affinity Von Willebrand Factor A1 Domain with Disulfide Mutation


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Crystal Structure of High-Affinity Von Willebrand Factor A1 Domain with Disulfide Mutation within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca2467 b:50.0 occ:1.00 OE2 B:GLU1290 2.2 39.2 1.0 O B:HOH2089 2.4 50.4 1.0 O B:HOH2088 2.4 36.8 1.0 O B:HOH2025 2.4 44.7 1.0 O B:HOH2024 2.4 52.0 1.0 CD B:GLU1290 3.2 53.1 1.0 OE1 B:GLU1290 3.4 55.9 1.0 O B:HOH2049 4.2 45.8 1.0 O B:HOH2023 4.4 51.4 1.0 CG B:GLU1290 4.5 49.4 1.0

Calcium binding site 3 out of 3 in the Crystal Structure of High-Affinity Von Willebrand Factor A1 Domain with Disulfide Mutation


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Crystal Structure of High-Affinity Von Willebrand Factor A1 Domain with Disulfide Mutation within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca2470 b:81.2 occ:1.00 O B:HOH2028 2.4 56.3 1.0 O B:HOH2017 2.4 62.6 1.0 O B:HOH2019 2.4 52.3 1.0 O B:HOH2018 3.2 48.1 1.0 O B:ARG1287 4.3 44.1 1.0 OE2 B:GLU1292 4.4 50.7 1.0 OE1 B:GLU1292 4.5 41.0 1.0 CD B:GLU1292 4.9 41.8 1.0

M.A.Blenner, X.Dong, T.A.Springer. Towards the Structural Basis of Regulation of Von Willebrand Factor Binding to Glycoprotein Ib J.Biol.Chem. V. 289 5565 2014.
ISSN: ISSN 0021-9258
PubMed: 24391089
DOI: 10.1074/JBC.M113.511220