Calcium in PDB 4cc0: Notch Ligand, Jagged-1, Contains An N-Terminal C2 Domain

The structure of Notch Ligand, Jagged-1, Contains An N-Terminal C2 Domain, PDB code: 4cc0 was solved by C.R.Chilakuri, D.Sheppard, M.X.G.Ilagan, L.R.Holt, F.Abbott, S.Liang, R.Kopan, P.A.Handford, S.M.Lea, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.19 / 2.32
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	55.980, 60.250, 62.650, 92.59, 104.44, 106.67
R / Rfree (%)	21.76 / 24.6

The binding sites of Calcium atom in the Notch Ligand, Jagged-1, Contains An N-Terminal C2 Domain (pdb code 4cc0). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Notch Ligand, Jagged-1, Contains An N-Terminal C2 Domain, PDB code: 4cc0:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Notch Ligand, Jagged-1, Contains An N-Terminal C2 Domain


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Notch Ligand, Jagged-1, Contains An N-Terminal C2 Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1338 b:59.0 occ:1.00 O A:HOH2005 2.4 38.6 1.0 O A:SER141 2.4 51.4 1.0 OD2 A:ASP72 2.4 52.0 1.0 OD1 A:ASP140 2.7 42.6 1.0 OD2 A:ASP140 2.7 48.6 1.0 CG A:ASP140 3.1 43.7 1.0 C A:SER141 3.5 53.7 1.0 CG A:ASP72 3.6 49.5 1.0 CB A:ASP72 4.1 43.2 1.0 N A:ASP72 4.2 43.3 1.0 N A:SER142 4.3 56.5 1.0 N A:SER141 4.3 44.3 1.0 CA A:SER142 4.4 59.1 1.0 CB A:SER142 4.4 63.0 1.0 O A:GLU70 4.5 50.1 1.0 CB A:ASP140 4.5 36.6 1.0 CA A:SER141 4.5 46.1 1.0 OD2 A:ASP69 4.6 77.8 1.0 OD1 A:ASP72 4.6 50.4 1.0 C A:ASP140 4.7 44.1 1.0 CA A:ASP72 4.8 41.7 1.0 C A:CYS71 4.9 49.6 1.0 CA A:CYS71 4.9 49.9 1.0 CB A:CYS55 5.0 53.1 1.0

Calcium binding site 2 out of 2 in the Notch Ligand, Jagged-1, Contains An N-Terminal C2 Domain


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Notch Ligand, Jagged-1, Contains An N-Terminal C2 Domain within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1299 b:58.4 occ:1.00 OD2 B:ASP72 2.3 64.4 1.0 OD1 B:ASP140 2.6 38.8 1.0 O B:SER141 2.8 46.9 1.0 OD2 B:ASP140 2.8 46.3 1.0 CG B:ASP140 3.1 42.5 1.0 CG B:ASP72 3.5 60.1 1.0 C B:SER141 3.7 47.1 1.0 CB B:ASP72 4.0 42.4 1.0 N B:ASP72 4.0 39.6 1.0 N B:SER142 4.4 50.5 1.0 N B:SER141 4.4 36.9 1.0 O B:CYS55 4.4 49.0 1.0 CA B:SER142 4.4 53.0 1.0 OD1 B:ASP72 4.5 61.9 1.0 O B:GLU70 4.5 47.3 1.0 CB B:ASP140 4.5 38.2 1.0 OG B:SER142 4.6 66.5 1.0 CA B:SER141 4.7 36.5 1.0 CA B:ASP72 4.7 38.9 1.0 CA B:CYS71 4.7 41.5 1.0 C B:CYS71 4.7 41.8 1.0 CB B:SER142 4.8 57.6 1.0 C B:ASP140 4.8 39.1 1.0 CB B:CYS55 4.9 43.6 1.0 C B:CYS55 4.9 49.2 1.0

C.R.Chilakuri, D.Sheppard, M.X.G.Ilagan, L.R.Holt, F.Abbott, S.Liang, R.Kopan, P.A.Handford, S.M.Lea. Structural Analysis Uncovers Lipid-Binding Properties of Notch Ligands Cell Rep. V. 5 861 2013.
ISSN: ISSN 2211-1247
PubMed: 24239355
DOI: 10.1016/J.CELREP.2013.10.029