Calcium in PDB 4ccc: Structure of Mouse Galactocerebrosidase with 4NBDG: Enzyme-Substrate Complex

All present enzymatic activity of Structure of Mouse Galactocerebrosidase with 4NBDG: Enzyme-Substrate Complex:
3.2.1.46;

The structure of Structure of Mouse Galactocerebrosidase with 4NBDG: Enzyme-Substrate Complex, PDB code: 4ccc was solved by C.H.Hill, S.C.Graham, R.J.Read, J.E.Deane, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	56.382 / 2.09
Space group	H 3 2
Cell size a, b, c (Å), α, β, γ (°)	250.012, 250.012, 77.790, 90.00, 90.00, 120.00
R / Rfree (%)	18.72 / 22.4

The binding sites of Calcium atom in the Structure of Mouse Galactocerebrosidase with 4NBDG: Enzyme-Substrate Complex (pdb code 4ccc). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Structure of Mouse Galactocerebrosidase with 4NBDG: Enzyme-Substrate Complex, PDB code: 4ccc:

Calcium binding site 1 out of 1 in the Structure of Mouse Galactocerebrosidase with 4NBDG: Enzyme-Substrate Complex


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structure of Mouse Galactocerebrosidase with 4NBDG: Enzyme-Substrate Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1669 b:72.2 occ:1.00 O A:PHE511 2.3 53.2 1.0 OD1 A:ASN479 2.4 53.7 1.0 O A:ASP477 2.4 55.8 1.0 O A:HOH2209 2.4 60.8 1.0 OD1 A:ASP660 2.5 51.1 1.0 CG A:ASP660 3.2 52.7 1.0 OD2 A:ASP660 3.2 58.6 1.0 CG A:ASN479 3.4 59.1 1.0 C A:PHE511 3.5 48.9 1.0 C A:ASP477 3.6 56.0 1.0 ND2 A:ASN479 4.0 61.2 1.0 CB A:PHE511 4.1 49.6 1.0 CA A:PHE511 4.1 51.1 1.0 OD1 A:ASN661 4.2 61.9 1.0 N A:ASN479 4.2 58.0 1.0 N A:PHE511 4.3 52.4 1.0 C A:PHE478 4.3 55.9 1.0 CB A:ASP477 4.5 58.2 1.0 CA A:ASP477 4.5 55.5 1.0 N A:THR512 4.5 45.8 1.0 CA A:ASN479 4.6 61.4 1.0 CB A:ASN479 4.6 60.4 1.0 CB A:PHE478 4.6 52.8 1.0 N A:PHE478 4.6 56.7 1.0 CB A:ASP660 4.6 51.5 1.0 O A:PHE478 4.7 55.8 1.0 CA A:PHE478 4.7 53.7 1.0 CA A:THR512 4.8 54.2 1.0 N A:ASN661 4.9 50.4 1.0

C.H.Hill, S.C.Graham, R.J.Read, J.E.Deane. Structural Snapshots Illustrate the Catalytic Cycle of Beta-Galactocerebrosidase, the Defective Enzyme in Krabbe Disease Proc.Natl.Acad.Sci.Usa V. 110 20479 2013.
ISSN: ISSN 0027-8424
PubMed: 24297913
DOI: 10.1073/PNAS.1311990110