Calcium in PDB 4clk: Crystal Structure of Human Soluble Adenylyl Cyclase in Complex with Alpha,Beta-Methyleneadenosine-5'-Triphosphate

Enzymatic activity of Crystal Structure of Human Soluble Adenylyl Cyclase in Complex with Alpha,Beta-Methyleneadenosine-5'-Triphosphate

All present enzymatic activity of Crystal Structure of Human Soluble Adenylyl Cyclase in Complex with Alpha,Beta-Methyleneadenosine-5'-Triphosphate:
4.6.1.1;

Protein crystallography data

The structure of Crystal Structure of Human Soluble Adenylyl Cyclase in Complex with Alpha,Beta-Methyleneadenosine-5'-Triphosphate, PDB code: 4clk was solved by S.Kleinboelting, M.Weyand, C.Steegborn, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	86.82 / 2.20
*Space group*	P 6₃
*Cell size a, b, c (Å), α, β, γ (°)*	100.250, 100.250, 97.450, 90.00, 90.00, 120.00
*R / R_free (%)*	17.605 / 23.664

Other elements in 4clk:

The structure of Crystal Structure of Human Soluble Adenylyl Cyclase in Complex with Alpha,Beta-Methyleneadenosine-5'-Triphosphate also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

Calcium Binding Sites:

The binding sites of Calcium atom in the Crystal Structure of Human Soluble Adenylyl Cyclase in Complex with Alpha,Beta-Methyleneadenosine-5'-Triphosphate (pdb code 4clk). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Crystal Structure of Human Soluble Adenylyl Cyclase in Complex with Alpha,Beta-Methyleneadenosine-5'-Triphosphate, PDB code: 4clk:

Calcium binding site 1 out of 1 in 4clk

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Calcium Binding Sites List in 4clk

Calcium binding site 1 out of 1 in the Crystal Structure of Human Soluble Adenylyl Cyclase in Complex with Alpha,Beta-Methyleneadenosine-5'-Triphosphate

Mono view

Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of Human Soluble Adenylyl Cyclase in Complex with Alpha,Beta-Methyleneadenosine-5'-Triphosphate within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Ca1470 b:78.8 occ:0.75	OD1	A:ASP99	2.3	57.9	1.0
	O1G	A:APC1468	2.5	50.0	0.8
	OD1	A:ASP47	2.5	61.2	1.0
	O1B	A:APC1468	2.7	42.1	0.8
	O	A:HOH2056	3.0	50.2	1.0
	O	A:ILE48	3.1	55.8	1.0
	CG	A:ASP99	3.2	54.3	1.0
	OD2	A:ASP99	3.5	55.6	1.0
	O1A	A:APC1468	3.7	50.5	0.8
	CG	A:ASP47	3.7	57.9	1.0
	PB	A:APC1468	3.7	45.4	0.8
	C3A	A:APC1468	3.8	48.3	0.8
	PG	A:APC1468	3.9	45.6	0.8
	O	A:HOH2054	4.1	51.4	1.0
	OD2	A:ASP47	4.1	54.8	1.0
	O3B	A:APC1468	4.2	44.6	0.8
	PA	A:APC1468	4.2	53.1	0.8
	C	A:ILE48	4.3	54.4	1.0
	O3G	A:APC1468	4.5	47.2	0.8
	CB	A:ALA100	4.5	33.4	1.0
	CB	A:ASP99	4.5	52.1	1.0
	O5'	A:APC1468	4.6	57.0	0.8
	N	A:ILE48	4.6	47.4	1.0
	N	A:ALA100	4.7	38.8	1.0
	C	A:ASP99	4.7	40.4	1.0
	N	A:ASP99	4.8	44.5	1.0
	CB	A:ASP47	4.9	50.8	1.0
	CA	A:ASP99	4.9	44.4	1.0

Reference:

S.Kleinboelting, A.Diaz, S.Moniot, J.Van Den Heuvel, M.Weyand, L.R.Levin, J.Buck, C.Steegborn. Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of Its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.Usa V. 111 3727 2014.
ISSN: ISSN 0027-8424
PubMed: 24567411
DOI: 10.1073/PNAS.1322778111

Page generated: Sat Jul 13 23:08:49 2024

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