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Calcium in PDB 4ecu: Human Dna Polymerase Eta - Dna Ternary Complex: Reaction in the at Crystal at pH 7.0 For 200 Sec

Enzymatic activity of Human Dna Polymerase Eta - Dna Ternary Complex: Reaction in the at Crystal at pH 7.0 For 200 Sec

All present enzymatic activity of Human Dna Polymerase Eta - Dna Ternary Complex: Reaction in the at Crystal at pH 7.0 For 200 Sec:
2.7.7.7;

Protein crystallography data

The structure of Human Dna Polymerase Eta - Dna Ternary Complex: Reaction in the at Crystal at pH 7.0 For 200 Sec, PDB code: 4ecu was solved by T.Nakamura, Y.Zhao, W.Yang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.10 / 1.95
Space group P 61
Cell size a, b, c (Å), α, β, γ (°) 98.786, 98.786, 82.431, 90.00, 90.00, 120.00
R / Rfree (%) 17.3 / 21.7

Other elements in 4ecu:

The structure of Human Dna Polymerase Eta - Dna Ternary Complex: Reaction in the at Crystal at pH 7.0 For 200 Sec also contains other interesting chemical elements:

Magnesium (Mg) 3 atoms

Calcium Binding Sites:

The binding sites of Calcium atom in the Human Dna Polymerase Eta - Dna Ternary Complex: Reaction in the at Crystal at pH 7.0 For 200 Sec (pdb code 4ecu). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Human Dna Polymerase Eta - Dna Ternary Complex: Reaction in the at Crystal at pH 7.0 For 200 Sec, PDB code: 4ecu:

Calcium binding site 1 out of 1 in 4ecu

Go back to Calcium Binding Sites List in 4ecu
Calcium binding site 1 out of 1 in the Human Dna Polymerase Eta - Dna Ternary Complex: Reaction in the at Crystal at pH 7.0 For 200 Sec


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Human Dna Polymerase Eta - Dna Ternary Complex: Reaction in the at Crystal at pH 7.0 For 200 Sec within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca502

b:9.4
occ:0.15
 MG A:MG503 0.0 9.2 0.8
O1B P:DTP504 2.1 13.6 0.5
O7 P:DPO505 2.1 14.6 0.5
O2A P:DTP504 2.2 16.4 0.5
O3G P:DTP504 2.2 14.7 0.5
O2 P:DPO505 2.2 13.6 0.5
OD1 A:ASP13 2.2 11.4 0.5
OD1 A:ASP13 2.3 13.6 0.5
OD1 A:ASP115 2.3 15.0 1.0
O A:MET14 2.3 7.8 1.0
OP1 P:DA9 2.4 16.7 0.5
CG A:ASP13 2.9 12.9 0.5
OD2 A:ASP13 2.9 16.0 0.5
PB P:DTP504 3.2 12.9 0.5
P1 P:DPO505 3.2 12.9 0.5
CG A:ASP115 3.3 16.8 1.0
PA P:DTP504 3.3 18.0 0.5
MG A:MG501 3.3 15.2 0.5
O3A P:DTP504 3.4 15.9 0.5
P2 P:DPO505 3.4 14.9 0.5
PG P:DTP504 3.5 14.9 0.5
CG A:ASP13 3.5 15.0 0.5
C A:MET14 3.5 8.2 1.0
O1 P:DPO505 3.5 15.7 0.5
OD2 A:ASP115 3.6 14.3 1.0
O4 P:DPO505 3.7 16.3 0.5
O3B P:DTP504 3.8 16.4 0.5
P P:DA9 3.9 19.3 0.5
C5' P:DTP504 3.9 15.0 0.5
O A:HOH843 3.9 24.8 1.0
NZ A:LYS231 4.0 11.3 1.0
N A:MET14 4.0 9.3 1.0
O5' P:DTP504 4.1 15.5 0.5
O A:HOH604 4.1 20.4 1.0
O2G P:DTP504 4.1 11.8 0.5
O5 P:DPO505 4.1 11.8 0.5
OD2 A:ASP13 4.2 23.1 0.5
CA A:MET14 4.3 9.9 1.0
C5' P:DA9 4.3 14.5 0.5
C A:ASP13 4.3 9.7 1.0
CB A:ASP13 4.3 10.5 0.5
O5' P:DA9 4.4 15.8 0.5
N A:ASP15 4.5 6.6 1.0
CB A:ASP13 4.5 10.1 0.5
N A:CYS16 4.5 9.9 1.0
CA A:ASP15 4.6 9.6 1.0
O2B P:DTP504 4.6 12.5 0.5
CB A:ASP115 4.6 11.2 1.0
O3 P:DPO505 4.6 12.2 0.5
O1A P:DTP504 4.6 17.9 0.5
O6 P:DPO505 4.6 15.7 0.5
MG P:MG506 4.7 22.3 0.5
C A:ASP15 4.7 14.2 1.0
O1G P:DTP504 4.7 15.7 0.5
O A:ASP13 4.7 9.9 1.0
N A:PHE17 4.7 7.6 1.0
CB A:MET14 4.7 7.8 1.0
CA A:ASP13 4.8 10.7 0.5
O3' P:DT8 4.8 17.6 0.5
CA A:ASP13 4.8 10.7 0.5
CB A:PHE17 4.8 7.5 1.0
OP2 P:DA9 4.8 18.2 0.5
CE A:LYS231 4.9 27.3 1.0
O A:ASP115 4.9 12.0 1.0
O3' P:DT8 4.9 16.9 0.5

Reference:

T.Nakamura, Y.Zhao, Y.Yamagata, Y.J.Hua, W.Yang. Watching Dna Polymerase Eta Make A Phosphodiester Bond Nature V. 487 196 2012.
ISSN: ISSN 0028-0836
PubMed: 22785315
DOI: 10.1038/NATURE11181
Page generated: Sat Jul 13 23:53:59 2024

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