Calcium in PDB 4gzp: N2 Neuraminidase of A/Tanzania/205/2010 H3N2 in Complex with Oseltamivir Carboxylate

The structure of N2 Neuraminidase of A/Tanzania/205/2010 H3N2 in Complex with Oseltamivir Carboxylate, PDB code: 4gzp was solved by X.Zhu, I.A.Wilson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.25 / 2.30
Space group	P 4 21 2
Cell size a, b, c (Å), α, β, γ (°)	110.123, 110.123, 78.274, 90.00, 90.00, 90.00
R / Rfree (%)	21.2 / 27.5

The binding sites of Calcium atom in the N2 Neuraminidase of A/Tanzania/205/2010 H3N2 in Complex with Oseltamivir Carboxylate (pdb code 4gzp). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the N2 Neuraminidase of A/Tanzania/205/2010 H3N2 in Complex with Oseltamivir Carboxylate, PDB code: 4gzp:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the N2 Neuraminidase of A/Tanzania/205/2010 H3N2 in Complex with Oseltamivir Carboxylate


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of N2 Neuraminidase of A/Tanzania/205/2010 H3N2 in Complex with Oseltamivir Carboxylate within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca510 b:38.2 occ:1.00 O A:ASP293 2.1 36.8 1.0 O A:HOH684 2.2 59.7 1.0 OD2 A:ASP324 2.3 39.6 1.0 O A:HIS347 2.4 41.1 1.0 O A:GLY297 2.4 40.7 1.0 O A:GLY345 2.5 47.5 1.0 C A:ASP293 3.4 36.7 1.0 C A:GLY297 3.4 40.1 1.0 CG A:ASP324 3.4 40.9 1.0 C A:GLY345 3.5 47.8 1.0 C A:HIS347 3.6 42.1 1.0 O A:HOH732 3.8 35.1 1.0 CA A:GLY345 4.0 48.6 1.0 CA A:GLY348 4.1 40.2 1.0 CA A:SER298 4.1 38.8 1.0 N A:SER298 4.1 39.6 1.0 CA A:ASN294 4.1 37.0 1.0 N A:ASN294 4.2 36.6 1.0 N A:GLY348 4.2 41.4 1.0 OD1 A:ASP324 4.3 41.6 1.0 CB A:ASP324 4.3 40.6 1.0 O A:GLY346 4.4 45.1 1.0 C A:ASN294 4.4 37.7 1.0 CA A:ASP293 4.4 36.3 1.0 N A:GLY297 4.4 40.0 1.0 CB A:ASP293 4.5 36.6 1.0 CA A:GLY297 4.5 40.1 1.0 C A:GLY346 4.5 45.0 1.0 N A:TRP295 4.6 38.2 1.0 N A:GLY346 4.6 47.1 1.0 N A:ASP293 4.6 35.7 1.0 O A:GLU344 4.7 50.5 1.0 N A:HIS347 4.7 43.9 1.0 CA A:HIS347 4.7 42.8 1.0 O A:ASN294 4.8 37.8 1.0 OD1 A:ASP293 4.8 35.5 1.0 CB A:SER298 4.9 38.9 1.0

Calcium binding site 2 out of 2 in the N2 Neuraminidase of A/Tanzania/205/2010 H3N2 in Complex with Oseltamivir Carboxylate


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of N2 Neuraminidase of A/Tanzania/205/2010 H3N2 in Complex with Oseltamivir Carboxylate within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca511 b:62.8 occ:0.25 O A:HOH636 3.8 42.7 1.0

X.Zhu, R.Mcbride, C.M.Nycholat, W.Yu, J.C.Paulson, I.A.Wilson. Influenza Virus Neuraminidases with Reduced Enzymatic Activity That Avidly Bind Sialic Acid Receptors. J.Virol. V. 86 13371 2012.
ISSN: ISSN 0022-538X
PubMed: 23015718
DOI: 10.1128/JVI.01426-12