Calcium in PDB 4i18: Crystal Structure of Human Prolactin Receptor Complexed with Fab Fragment

The structure of Crystal Structure of Human Prolactin Receptor Complexed with Fab Fragment, PDB code: 4i18 was solved by E.M.Duguid, S.Mukherjee, J.L.Kouadio, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.51 / 3.24
Space group	P 61
Cell size a, b, c (Å), α, β, γ (°)	285.826, 285.826, 62.248, 90.00, 90.00, 120.00
R / Rfree (%)	19.1 / 24.6

The binding sites of Calcium atom in the Crystal Structure of Human Prolactin Receptor Complexed with Fab Fragment (pdb code 4i18). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Crystal Structure of Human Prolactin Receptor Complexed with Fab Fragment, PDB code: 4i18:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Crystal Structure of Human Prolactin Receptor Complexed with Fab Fragment


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of Human Prolactin Receptor Complexed with Fab Fragment within 5.0Å range: probe atom residue distance (Å) B Occ H:Ca301 b:52.2 occ:1.00 OG H:SER78 1.9 46.9 1.0 OG A:SER78 2.5 41.4 1.0 CB H:SER78 3.1 41.6 1.0 OD1 H:ASP76 3.3 58.5 1.0 CB A:SER78 3.3 40.7 1.0 CA H:SER78 4.2 41.9 1.0 N H:SER78 4.2 44.1 1.0 CG H:ASP76 4.3 53.4 1.0 OD1 A:ASP76 4.4 50.2 1.0 OD2 H:ASP76 4.5 48.9 1.0 OD2 A:ASP76 4.6 58.4 1.0 CA A:SER78 4.8 39.0 1.0 CG A:ASP76 5.0 49.9 1.0

Calcium binding site 2 out of 2 in the Crystal Structure of Human Prolactin Receptor Complexed with Fab Fragment


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Crystal Structure of Human Prolactin Receptor Complexed with Fab Fragment within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca301 b:53.4 occ:1.00 OD2 B:ASP2 3.2 50.8 1.0 N B:TYR95 3.5 40.2 1.0 OG B:SER94 3.8 40.9 1.0 CB B:TYR95 4.0 40.0 1.0 CG B:ASP2 4.1 47.8 1.0 CA B:SER94 4.1 40.7 1.0 N B:TYR96 4.2 40.5 1.0 CA B:TYR95 4.3 38.9 1.0 C B:SER94 4.3 40.8 1.0 CD2 B:TYR96 4.3 39.3 1.0 CB B:SER94 4.4 40.8 1.0 OD1 B:ASP2 4.5 46.8 1.0 CB R:PRO196 4.7 32.9 1.0 C B:TYR95 4.8 39.4 1.0 CD1 B:ILE3 4.9 47.7 1.0 CE2 B:TYR96 4.9 40.2 1.0 CG R:PRO196 4.9 32.9 1.0

S.S.Rizk, J.L.Kouadio, A.Szymborska, E.M.Duguid, S.Mukherjee, J.Zheng, C.V.Clevenger, A.A.Kossiakoff. Engineering Synthetic Antigen Binders For Allosteric Inhibition of Prolactin Receptor Signaling To Be Published.