Calcium in PDB 4i9w: Human Two Pore Domain K+ Channel Traak (K2P4.1) - Fab Complex Structure

The structure of Human Two Pore Domain K+ Channel Traak (K2P4.1) - Fab Complex Structure, PDB code: 4i9w was solved by S.G.Brohawn, R.Mackinnon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.60 / 2.75
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	80.887, 138.905, 97.461, 90.00, 94.87, 90.00
R / Rfree (%)	20.1 / 23.6

The structure of Human Two Pore Domain K+ Channel Traak (K2P4.1) - Fab Complex Structure also contains other interesting chemical elements:

Potassium

(K)

5 atoms

The binding sites of Calcium atom in the Human Two Pore Domain K+ Channel Traak (K2P4.1) - Fab Complex Structure (pdb code 4i9w). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Human Two Pore Domain K+ Channel Traak (K2P4.1) - Fab Complex Structure, PDB code: 4i9w:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Human Two Pore Domain K+ Channel Traak (K2P4.1) - Fab Complex Structure


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Human Two Pore Domain K+ Channel Traak (K2P4.1) - Fab Complex Structure within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca403 b:0.8 occ:1.00 OD2 A:ASP115 2.3 1.0 1.0 O A:SER112 2.4 88.5 1.0 OD1 A:ASP249 2.4 0.9 1.0 OD1 A:ASP115 2.8 0.1 1.0 OG A:SER118 2.8 92.5 1.0 CG A:ASP115 2.9 98.9 1.0 OD2 A:ASP249 3.0 0.2 1.0 CG A:ASP249 3.0 0.9 1.0 C A:SER112 3.5 92.4 1.0 CB A:SER118 3.9 88.8 1.0 N A:SER112 3.9 0.2 1.0 O A:SER110 4.2 0.5 1.0 CA A:SER112 4.2 0.1 1.0 CB A:ASP115 4.4 98.5 1.0 CB A:ASP249 4.5 0.7 1.0 N A:ALA113 4.5 82.1 1.0 C A:HIS111 4.6 0.7 1.0 CB A:SER112 4.7 0.4 1.0 N A:SER118 4.7 92.2 1.0 CA A:ALA113 4.8 77.5 1.0 O A:ALA248 4.8 0.2 1.0 C A:SER110 4.8 0.9 1.0 CA A:SER118 4.9 88.7 1.0 CA A:HIS111 5.0 0.3 1.0 CA A:ASP249 5.0 0.5 1.0

Calcium binding site 2 out of 2 in the Human Two Pore Domain K+ Channel Traak (K2P4.1) - Fab Complex Structure


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Human Two Pore Domain K+ Channel Traak (K2P4.1) - Fab Complex Structure within 5.0Å range: probe atom residue distance (Å) B Occ G:Ca301 b:1.0 occ:1.00 OE1 G:GLU10 2.4 0.5 1.0 O G:LYS19 2.6 81.0 1.0 OE2 G:GLU10 2.8 0.8 1.0 CD G:GLU10 2.9 0.6 1.0 C G:LYS19 3.8 76.8 1.0 N G:LYS19 4.2 82.3 1.0 CG G:GLU10 4.3 0.3 1.0 CA G:LYS19 4.5 76.8 1.0 CB G:LYS19 4.7 81.7 1.0 N G:THR20 4.8 76.4 1.0

S.G.Brohawn, E.B.Campbell, R.Mackinnon. Domain-Swapped Chain Connectivity and Gated Membrane Access in A Fab-Mediated Crystal of the Human Traak K+ Channel. Proc.Natl.Acad.Sci.Usa V. 110 2129 2013.
ISSN: ISSN 0027-8424
PubMed: 23341632
DOI: 10.1073/PNAS.1218950110