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Calcium in PDB 4ish: Structure of Factor Viia in Complex with the Inhibitor Bms-593214 Also Known As 2'-[(6R,6AR,11BR)-2-Carbamimidoyl-6,6A,7,11B-Tetrahydro-5H- Indeno[2,1-C]Quinolin-6-Yl]-5'-Hydroxy-4'-Methoxybiphenyl-4- Carboxylic AcidEnzymatic activity of Structure of Factor Viia in Complex with the Inhibitor Bms-593214 Also Known As 2'-[(6R,6AR,11BR)-2-Carbamimidoyl-6,6A,7,11B-Tetrahydro-5H- Indeno[2,1-C]Quinolin-6-Yl]-5'-Hydroxy-4'-Methoxybiphenyl-4- Carboxylic Acid
All present enzymatic activity of Structure of Factor Viia in Complex with the Inhibitor Bms-593214 Also Known As 2'-[(6R,6AR,11BR)-2-Carbamimidoyl-6,6A,7,11B-Tetrahydro-5H- Indeno[2,1-C]Quinolin-6-Yl]-5'-Hydroxy-4'-Methoxybiphenyl-4- Carboxylic Acid:
3.4.21.21; Protein crystallography data
The structure of Structure of Factor Viia in Complex with the Inhibitor Bms-593214 Also Known As 2'-[(6R,6AR,11BR)-2-Carbamimidoyl-6,6A,7,11B-Tetrahydro-5H- Indeno[2,1-C]Quinolin-6-Yl]-5'-Hydroxy-4'-Methoxybiphenyl-4- Carboxylic Acid, PDB code: 4ish
was solved by
A.Wei,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Calcium Binding Sites:
The binding sites of Calcium atom in the Structure of Factor Viia in Complex with the Inhibitor Bms-593214 Also Known As 2'-[(6R,6AR,11BR)-2-Carbamimidoyl-6,6A,7,11B-Tetrahydro-5H- Indeno[2,1-C]Quinolin-6-Yl]-5'-Hydroxy-4'-Methoxybiphenyl-4- Carboxylic Acid
(pdb code 4ish). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Structure of Factor Viia in Complex with the Inhibitor Bms-593214 Also Known As 2'-[(6R,6AR,11BR)-2-Carbamimidoyl-6,6A,7,11B-Tetrahydro-5H- Indeno[2,1-C]Quinolin-6-Yl]-5'-Hydroxy-4'-Methoxybiphenyl-4- Carboxylic Acid, PDB code: 4ish: Calcium binding site 1 out of 1 in 4ishGo back to Calcium Binding Sites List in 4ish
Calcium binding site 1 out
of 1 in the Structure of Factor Viia in Complex with the Inhibitor Bms-593214 Also Known As 2'-[(6R,6AR,11BR)-2-Carbamimidoyl-6,6A,7,11B-Tetrahydro-5H- Indeno[2,1-C]Quinolin-6-Yl]-5'-Hydroxy-4'-Methoxybiphenyl-4- Carboxylic Acid
Mono view Stereo pair view
Reference:
E.S.Priestley,
I.De Lucca,
J.Zhou,
J.Zhou,
E.Saiah,
R.Stanton,
L.Robinson,
J.M.Luettgen,
A.Wei,
X.Wen,
R.M.Knabb,
P.C.Wong,
R.R.Wexler.
Discovery and Gram-Scale Synthesis of Bms-593214, A Potent, Selective Fviia Inhibitor. Bioorg.Med.Chem.Lett. V. 23 2432 2013.
Page generated: Sat Dec 12 04:52:17 2020
ISSN: ISSN 0960-894X PubMed: 23478148 DOI: 10.1016/J.BMCL.2013.02.013 |
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