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Calcium in PDB 4jyu: Structure of Factor Viia in Complex with the Inhibitor (2R)-2-[(1- Aminoisoquinolin-6-Yl)Amino]-2-[3-Ethoxy-4-(Propan-2-Yloxy)Phenyl]-N- (Phenylsulfonyl)EthanamideEnzymatic activity of Structure of Factor Viia in Complex with the Inhibitor (2R)-2-[(1- Aminoisoquinolin-6-Yl)Amino]-2-[3-Ethoxy-4-(Propan-2-Yloxy)Phenyl]-N- (Phenylsulfonyl)Ethanamide
All present enzymatic activity of Structure of Factor Viia in Complex with the Inhibitor (2R)-2-[(1- Aminoisoquinolin-6-Yl)Amino]-2-[3-Ethoxy-4-(Propan-2-Yloxy)Phenyl]-N- (Phenylsulfonyl)Ethanamide:
3.4.21.21; Protein crystallography data
The structure of Structure of Factor Viia in Complex with the Inhibitor (2R)-2-[(1- Aminoisoquinolin-6-Yl)Amino]-2-[3-Ethoxy-4-(Propan-2-Yloxy)Phenyl]-N- (Phenylsulfonyl)Ethanamide, PDB code: 4jyu
was solved by
A.Wei,
R.Anumula,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Calcium Binding Sites:
The binding sites of Calcium atom in the Structure of Factor Viia in Complex with the Inhibitor (2R)-2-[(1- Aminoisoquinolin-6-Yl)Amino]-2-[3-Ethoxy-4-(Propan-2-Yloxy)Phenyl]-N- (Phenylsulfonyl)Ethanamide
(pdb code 4jyu). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Structure of Factor Viia in Complex with the Inhibitor (2R)-2-[(1- Aminoisoquinolin-6-Yl)Amino]-2-[3-Ethoxy-4-(Propan-2-Yloxy)Phenyl]-N- (Phenylsulfonyl)Ethanamide, PDB code: 4jyu: Calcium binding site 1 out of 1 in 4jyuGo back to Calcium Binding Sites List in 4jyu
Calcium binding site 1 out
of 1 in the Structure of Factor Viia in Complex with the Inhibitor (2R)-2-[(1- Aminoisoquinolin-6-Yl)Amino]-2-[3-Ethoxy-4-(Propan-2-Yloxy)Phenyl]-N- (Phenylsulfonyl)Ethanamide
Mono view Stereo pair view
Reference:
P.W.Glunz,
X.Zhang,
Y.Zou,
I.Delucca,
A.H.Nirschl,
X.Cheng,
C.A.Weigelt,
D.L.Cheney,
A.Wei,
R.Anumula,
J.M.Luettgen,
A.R.Rendina,
M.Harpel,
G.Luo,
R.Knabb,
P.C.Wong,
R.R.Wexler,
E.S.Priestley.
Nonbenzamidine Acylsulfonamide Tissue Factor-Factor Viia Inhibitors. Bioorg.Med.Chem.Lett. V. 23 5244 2013.
Page generated: Sat Dec 12 04:53:52 2020
ISSN: ISSN 0960-894X PubMed: 23845220 DOI: 10.1016/J.BMCL.2013.06.027 |
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