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Atomistry » Calcium » PDB 4jo1-4k0g » 4jyv | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Calcium » PDB 4jo1-4k0g » 4jyv » |
Calcium in PDB 4jyv: Structure of Factor Viia in Complex with the Inhibitor (2R)-2-[3- Ethoxy-4-(Propan-2-Yloxy)Phenyl]-2-(Isoquinolin-6-Ylamino)-N-[(3- Sulfamoylphenyl)Sulfonyl]EthanamideEnzymatic activity of Structure of Factor Viia in Complex with the Inhibitor (2R)-2-[3- Ethoxy-4-(Propan-2-Yloxy)Phenyl]-2-(Isoquinolin-6-Ylamino)-N-[(3- Sulfamoylphenyl)Sulfonyl]Ethanamide
All present enzymatic activity of Structure of Factor Viia in Complex with the Inhibitor (2R)-2-[3- Ethoxy-4-(Propan-2-Yloxy)Phenyl]-2-(Isoquinolin-6-Ylamino)-N-[(3- Sulfamoylphenyl)Sulfonyl]Ethanamide:
3.4.21.21; Protein crystallography data
The structure of Structure of Factor Viia in Complex with the Inhibitor (2R)-2-[3- Ethoxy-4-(Propan-2-Yloxy)Phenyl]-2-(Isoquinolin-6-Ylamino)-N-[(3- Sulfamoylphenyl)Sulfonyl]Ethanamide, PDB code: 4jyv
was solved by
A.Wei,
R.Anumula,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Calcium Binding Sites:
The binding sites of Calcium atom in the Structure of Factor Viia in Complex with the Inhibitor (2R)-2-[3- Ethoxy-4-(Propan-2-Yloxy)Phenyl]-2-(Isoquinolin-6-Ylamino)-N-[(3- Sulfamoylphenyl)Sulfonyl]Ethanamide
(pdb code 4jyv). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Structure of Factor Viia in Complex with the Inhibitor (2R)-2-[3- Ethoxy-4-(Propan-2-Yloxy)Phenyl]-2-(Isoquinolin-6-Ylamino)-N-[(3- Sulfamoylphenyl)Sulfonyl]Ethanamide, PDB code: 4jyv: Calcium binding site 1 out of 1 in 4jyvGo back to![]() ![]()
Calcium binding site 1 out
of 1 in the Structure of Factor Viia in Complex with the Inhibitor (2R)-2-[3- Ethoxy-4-(Propan-2-Yloxy)Phenyl]-2-(Isoquinolin-6-Ylamino)-N-[(3- Sulfamoylphenyl)Sulfonyl]Ethanamide
![]() Mono view ![]() Stereo pair view
Reference:
P.W.Glunz,
X.Zhang,
Y.Zou,
I.Delucca,
A.H.Nirschl,
X.Cheng,
C.A.Weigelt,
D.L.Cheney,
A.Wei,
R.Anumula,
J.M.Luettgen,
A.R.Rendina,
M.Harpel,
G.Luo,
R.Knabb,
P.C.Wong,
R.R.Wexler,
E.S.Priestley.
Nonbenzamidine Acylsulfonamide Tissue Factor-Factor Viia Inhibitors. Bioorg.Med.Chem.Lett. V. 23 5244 2013.
Page generated: Tue Jul 8 23:16:54 2025
ISSN: ISSN 0960-894X PubMed: 23845220 DOI: 10.1016/J.BMCL.2013.06.027 |
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