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Atomistry » Calcium » PDB 4jo1-4k0g » 4jze » |
Calcium in PDB 4jze: Structure of Factor Viia in Complex with the Inhibitor 2-{2-[(1- Aminoisoquinolin-6-Yl)Carbamoyl]-6-Methoxypyridin-3-Yl}-5-{[(2S)-1- Hydroxy-3,3-Dimethylbutan-2-Yl]Carbamoyl}Benzoic AcidEnzymatic activity of Structure of Factor Viia in Complex with the Inhibitor 2-{2-[(1- Aminoisoquinolin-6-Yl)Carbamoyl]-6-Methoxypyridin-3-Yl}-5-{[(2S)-1- Hydroxy-3,3-Dimethylbutan-2-Yl]Carbamoyl}Benzoic Acid
All present enzymatic activity of Structure of Factor Viia in Complex with the Inhibitor 2-{2-[(1- Aminoisoquinolin-6-Yl)Carbamoyl]-6-Methoxypyridin-3-Yl}-5-{[(2S)-1- Hydroxy-3,3-Dimethylbutan-2-Yl]Carbamoyl}Benzoic Acid:
3.4.21.21; Protein crystallography data
The structure of Structure of Factor Viia in Complex with the Inhibitor 2-{2-[(1- Aminoisoquinolin-6-Yl)Carbamoyl]-6-Methoxypyridin-3-Yl}-5-{[(2S)-1- Hydroxy-3,3-Dimethylbutan-2-Yl]Carbamoyl}Benzoic Acid, PDB code: 4jze
was solved by
A.Wei,
R.Anumula,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Calcium Binding Sites:
The binding sites of Calcium atom in the Structure of Factor Viia in Complex with the Inhibitor 2-{2-[(1- Aminoisoquinolin-6-Yl)Carbamoyl]-6-Methoxypyridin-3-Yl}-5-{[(2S)-1- Hydroxy-3,3-Dimethylbutan-2-Yl]Carbamoyl}Benzoic Acid
(pdb code 4jze). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Structure of Factor Viia in Complex with the Inhibitor 2-{2-[(1- Aminoisoquinolin-6-Yl)Carbamoyl]-6-Methoxypyridin-3-Yl}-5-{[(2S)-1- Hydroxy-3,3-Dimethylbutan-2-Yl]Carbamoyl}Benzoic Acid, PDB code: 4jze: Calcium binding site 1 out of 1 in 4jzeGo back to Calcium Binding Sites List in 4jze
Calcium binding site 1 out
of 1 in the Structure of Factor Viia in Complex with the Inhibitor 2-{2-[(1- Aminoisoquinolin-6-Yl)Carbamoyl]-6-Methoxypyridin-3-Yl}-5-{[(2S)-1- Hydroxy-3,3-Dimethylbutan-2-Yl]Carbamoyl}Benzoic Acid
Mono view Stereo pair view
Reference:
S.A.Bolton,
J.C.Sutton,
R.Anumula,
G.S.Bisacchi,
B.Jacobson,
W.A.Slusarchyk,
U.D.Treuner,
S.C.Wu,
G.Zhao,
Z.Pi,
S.Sheriff,
R.A.Smirk,
S.Bisaha,
D.L.Cheney,
A.Wei,
W.A.Schumacher,
K.S.Hartl,
E.Liu,
R.Zahler,
S.M.Seiler.
Discovery of Nonbenzamidine Factor Viia Inhibitors Using A Biaryl Acid Scaffold. Bioorg.Med.Chem.Lett. V. 23 5239 2013.
Page generated: Sun Jul 14 08:43:14 2024
ISSN: ISSN 0960-894X PubMed: 23927973 DOI: 10.1016/J.BMCL.2013.06.028 |
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