Calcium in PDB 4kxa: Crystal Structure of Human Aminopeptidase A Complexed with Aspartate and Calcium

Enzymatic activity of Crystal Structure of Human Aminopeptidase A Complexed with Aspartate and Calcium

All present enzymatic activity of Crystal Structure of Human Aminopeptidase A Complexed with Aspartate and Calcium:
3.4.11.7;

Protein crystallography data

The structure of Crystal Structure of Human Aminopeptidase A Complexed with Aspartate and Calcium, PDB code: 4kxa was solved by Y.Yang, C.Liu, Y.Y.Lin, F.Li, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	48.57 / 2.40
*Space group*	P 6₄ 2 2
*Cell size a, b, c (Å), α, β, γ (°)*	142.093, 142.093, 237.414, 90.00, 90.00, 120.00
*R / R_free (%)*	15.2 / 22.4

Other elements in 4kxa:

The structure of Crystal Structure of Human Aminopeptidase A Complexed with Aspartate and Calcium also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

Calcium Binding Sites:

The binding sites of Calcium atom in the Crystal Structure of Human Aminopeptidase A Complexed with Aspartate and Calcium (pdb code 4kxa). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Crystal Structure of Human Aminopeptidase A Complexed with Aspartate and Calcium, PDB code: 4kxa:

Calcium binding site 1 out of 1 in 4kxa

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Calcium Binding Sites List in 4kxa

Calcium binding site 1 out of 1 in the Crystal Structure of Human Aminopeptidase A Complexed with Aspartate and Calcium

Mono view

Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of Human Aminopeptidase A Complexed with Aspartate and Calcium within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Ca1001 b:50.3 occ:0.50	O	A:HOH1586	2.4	63.0	1.0
	O	A:GLU223	2.5	53.2	1.0
	OD2	A:ASP221	2.5	55.4	1.0
	O	A:HOH1106	2.5	82.1	1.0
	O	A:HOH1168	2.5	62.4	1.0
	OD1	A:ASP1019	3.3	87.4	1.0
	CG	A:ASP221	3.3	49.3	1.0
	C	A:GLU223	3.5	50.2	1.0
	N	A:GLU223	3.6	51.7	1.0
	OD1	A:ASP221	3.7	51.0	1.0
	OD2	A:ASP1019	3.7	90.4	1.0
	CG	A:ASP1019	3.9	75.0	1.0
	CA	A:GLU223	3.9	51.4	1.0
	O	A:HOH1435	4.0	62.6	1.0
	OG1	A:THR356	4.2	63.9	1.0
	CB	A:GLU223	4.2	54.0	1.0
	C	A:HIS222	4.2	52.7	1.0
	N	A:HIS222	4.4	51.7	1.0
	CB	A:ASP221	4.4	46.8	1.0
	C	A:ASP221	4.5	46.7	1.0
	N	A:PRO224	4.7	51.8	1.0
	O	A:ASP221	4.8	49.5	1.0
	CA	A:HIS222	4.8	51.0	1.0
	OD2	A:ASP226	4.8	53.6	1.0
	O	A:HIS222	4.8	52.2	1.0
	O	A:HOH1391	4.8	72.9	1.0
	O	A:HOH1252	4.9	78.1	1.0
	CG2	A:THR356	4.9	58.5	1.0
	CA	A:ASP221	5.0	47.6	1.0

Reference:

Y.Yang, C.Liu, Y.L.Lin, F.Li. Structural Insights Into Central Hypertension Regulation By Human Aminopeptidase A. J.Biol.Chem. V. 288 25638 2013.
ISSN: ISSN 0021-9258
PubMed: 23888046
DOI: 10.1074/JBC.M113.494955

Page generated: Sun Jul 14 09:20:31 2024

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