Calcium in PDB 4mcq: A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyldi-Gamma-L-Glutamic Acid (Pteroyltri- Gamma-L-Glutamic Acid)

Enzymatic activity of A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyldi-Gamma-L-Glutamic Acid (Pteroyltri- Gamma-L-Glutamic Acid)

All present enzymatic activity of A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyldi-Gamma-L-Glutamic Acid (Pteroyltri- Gamma-L-Glutamic Acid):
3.4.17.21;

Protein crystallography data

The structure of A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyldi-Gamma-L-Glutamic Acid (Pteroyltri- Gamma-L-Glutamic Acid), PDB code: 4mcq was solved by M.Navratil, C.Barinka, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	22.96 / 2.00
*Space group*	I 2 2 2
*Cell size a, b, c (Å), α, β, γ (°)*	101.646, 130.140, 159.867, 90.00, 90.00, 90.00
*R / R_free (%)*	13.7 / 17.2

Other elements in 4mcq:

Chlorine	(Cl)	1 atom
Zinc	(Zn)	2 atoms

Calcium Binding Sites:

The binding sites of Calcium atom in the A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyldi-Gamma-L-Glutamic Acid (Pteroyltri- Gamma-L-Glutamic Acid) (pdb code 4mcq). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyldi-Gamma-L-Glutamic Acid (Pteroyltri- Gamma-L-Glutamic Acid), PDB code: 4mcq:

Calcium binding site 1 out of 1 in 4mcq

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Calcium Binding Sites List in 4mcq

Calcium binding site 1 out of 1 in the A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyldi-Gamma-L-Glutamic Acid (Pteroyltri- Gamma-L-Glutamic Acid)

Mono view

Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyldi-Gamma-L-Glutamic Acid (Pteroyltri- Gamma-L-Glutamic Acid) within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Ca803 b:16.5 occ:1.00	OE2	A:GLU436	2.3	16.1	1.0
	O	A:TYR272	2.3	16.8	1.0
	O	A:THR269	2.4	17.5	1.0
	O	A:HOH906	2.4	16.8	1.0
	OE1	A:GLU433	2.4	16.4	1.0
	OG1	A:THR269	2.4	16.6	1.0
	OE2	A:GLU433	2.4	17.2	1.0
	CD	A:GLU433	2.7	15.7	1.0
	CB	A:THR269	3.3	15.4	1.0
	C	A:THR269	3.3	16.3	1.0
	C	A:TYR272	3.4	16.4	1.0
	CD	A:GLU436	3.5	15.9	1.0
	CA	A:THR269	3.9	16.1	1.0
	OE1	A:GLU436	3.9	16.4	1.0
	N	A:TYR272	4.0	16.2	1.0
	CA	A:PRO273	4.2	17.7	1.0
	N	A:ALA274	4.2	16.9	1.0
	CB	A:ASP266	4.2	17.4	1.0
	CG	A:GLU433	4.3	15.5	1.0
	N	A:PRO273	4.3	17.4	1.0
	N	A:PRO270	4.3	16.5	1.0
	CA	A:TYR272	4.4	16.4	1.0
	C	A:PRO273	4.4	18.0	1.0
	CA	A:PRO270	4.5	16.4	1.0
	N	A:ASP266	4.5	17.2	1.0
	O	A:ASP266	4.5	17.2	1.0
	N	A:GLY271	4.5	16.4	1.0
	O	A:ALA264	4.6	16.9	1.0
	CG2	A:THR269	4.6	15.0	1.0
	N	A:THR269	4.6	16.3	1.0
	CG	A:GLU436	4.7	16.0	1.0
	OD2	A:ASP266	4.7	19.1	1.0
	C	A:PRO270	4.8	16.8	1.0
	CB	A:ALA274	4.9	16.2	1.0
	CA	A:ASP266	4.9	16.8	1.0
	CB	A:GLU436	4.9	14.5	1.0
	CA	A:GLU433	5.0	14.9	1.0
	CA	A:ALA274	5.0	17.5	1.0

Reference:

M.Navratil, J.Ptacek, P.Sacha, J.Starkova, J.Lubkowski, C.Barinka, J.Konvalinka. Structural and Biochemical Characterization of the Folyl-Poly-Gamma-L-Glutamate Hydrolyzing Activity of Human Glutamate Carboxypeptidase II. Febs J. V. 281 3228 2014.
ISSN: ISSN 1742-464X
PubMed: 24863754
DOI: 10.1111/FEBS.12857

Page generated: Sun Jul 14 10:20:23 2024

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