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Calcium in PDB 4mcq: A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyldi-Gamma-L-Glutamic Acid (Pteroyltri- Gamma-L-Glutamic Acid)

Enzymatic activity of A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyldi-Gamma-L-Glutamic Acid (Pteroyltri- Gamma-L-Glutamic Acid)

All present enzymatic activity of A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyldi-Gamma-L-Glutamic Acid (Pteroyltri- Gamma-L-Glutamic Acid):
3.4.17.21;

Protein crystallography data

The structure of A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyldi-Gamma-L-Glutamic Acid (Pteroyltri- Gamma-L-Glutamic Acid), PDB code: 4mcq was solved by M.Navratil, C.Barinka, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 22.96 / 2.00
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 101.646, 130.140, 159.867, 90.00, 90.00, 90.00
R / Rfree (%) 13.7 / 17.2

Other elements in 4mcq:

The structure of A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyldi-Gamma-L-Glutamic Acid (Pteroyltri- Gamma-L-Glutamic Acid) also contains other interesting chemical elements:

Chlorine (Cl) 1 atom
Zinc (Zn) 2 atoms

Calcium Binding Sites:

The binding sites of Calcium atom in the A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyldi-Gamma-L-Glutamic Acid (Pteroyltri- Gamma-L-Glutamic Acid) (pdb code 4mcq). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyldi-Gamma-L-Glutamic Acid (Pteroyltri- Gamma-L-Glutamic Acid), PDB code: 4mcq:

Calcium binding site 1 out of 1 in 4mcq

Go back to Calcium Binding Sites List in 4mcq
Calcium binding site 1 out of 1 in the A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyldi-Gamma-L-Glutamic Acid (Pteroyltri- Gamma-L-Glutamic Acid)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyldi-Gamma-L-Glutamic Acid (Pteroyltri- Gamma-L-Glutamic Acid) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca803

b:16.5
occ:1.00
 OE2 A:GLU436 2.3 16.1 1.0
O A:TYR272 2.3 16.8 1.0
O A:THR269 2.4 17.5 1.0
O A:HOH906 2.4 16.8 1.0
OE1 A:GLU433 2.4 16.4 1.0
OG1 A:THR269 2.4 16.6 1.0
OE2 A:GLU433 2.4 17.2 1.0
CD A:GLU433 2.7 15.7 1.0
CB A:THR269 3.3 15.4 1.0
C A:THR269 3.3 16.3 1.0
C A:TYR272 3.4 16.4 1.0
CD A:GLU436 3.5 15.9 1.0
CA A:THR269 3.9 16.1 1.0
OE1 A:GLU436 3.9 16.4 1.0
N A:TYR272 4.0 16.2 1.0
CA A:PRO273 4.2 17.7 1.0
N A:ALA274 4.2 16.9 1.0
CB A:ASP266 4.2 17.4 1.0
CG A:GLU433 4.3 15.5 1.0
N A:PRO273 4.3 17.4 1.0
N A:PRO270 4.3 16.5 1.0
CA A:TYR272 4.4 16.4 1.0
C A:PRO273 4.4 18.0 1.0
CA A:PRO270 4.5 16.4 1.0
N A:ASP266 4.5 17.2 1.0
O A:ASP266 4.5 17.2 1.0
N A:GLY271 4.5 16.4 1.0
O A:ALA264 4.6 16.9 1.0
CG2 A:THR269 4.6 15.0 1.0
N A:THR269 4.6 16.3 1.0
CG A:GLU436 4.7 16.0 1.0
OD2 A:ASP266 4.7 19.1 1.0
C A:PRO270 4.8 16.8 1.0
CB A:ALA274 4.9 16.2 1.0
CA A:ASP266 4.9 16.8 1.0
CB A:GLU436 4.9 14.5 1.0
CA A:GLU433 5.0 14.9 1.0
CA A:ALA274 5.0 17.5 1.0

Reference:

M.Navratil, J.Ptacek, P.Sacha, J.Starkova, J.Lubkowski, C.Barinka, J.Konvalinka. Structural and Biochemical Characterization of the Folyl-Poly-Gamma-L-Glutamate Hydrolyzing Activity of Human Glutamate Carboxypeptidase II. Febs J. V. 281 3228 2014.
ISSN: ISSN 1742-464X
PubMed: 24863754
DOI: 10.1111/FEBS.12857
Page generated: Sun Jul 14 10:20:23 2024

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