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Calcium in PDB 4mhx: Crystal Structure of Sulfamidase

Enzymatic activity of Crystal Structure of Sulfamidase

All present enzymatic activity of Crystal Structure of Sulfamidase:
3.10.1.1;

Protein crystallography data

The structure of Crystal Structure of Sulfamidase, PDB code: 4mhx was solved by N.S.Sidhu, I.Uson, K.Schreiber, K.Proepper, S.Becker, J.Gaertner, R.Kraetzner, R.Steinfeld, G.M.Sheldrick, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 44.30 / 2.00
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 61.380, 107.900, 79.790, 90.00, 104.07, 90.00
R / Rfree (%) 19.2 / 23

Other elements in 4mhx:

The structure of Crystal Structure of Sulfamidase also contains other interesting chemical elements:

Magnesium (Mg) 2 atoms

Calcium Binding Sites:

The binding sites of Calcium atom in the Crystal Structure of Sulfamidase (pdb code 4mhx). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Crystal Structure of Sulfamidase, PDB code: 4mhx:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in 4mhx

Go back to Calcium Binding Sites List in 4mhx
Calcium binding site 1 out of 2 in the Crystal Structure of Sulfamidase


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of Sulfamidase within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca601

b:46.2
occ:1.00
OD2 A:ASP273 2.2 31.6 1.0
OD1 A:ASP32 2.2 44.8 1.0
OD1 A:ASP31 2.4 40.3 1.0
OD1 A:ASN274 2.6 39.6 1.0
OG2 A:FGP70 2.6 56.1 1.0
O2P A:FGP70 2.6 76.4 1.0
CG A:ASP273 2.9 33.6 1.0
OD1 A:ASP273 3.0 34.2 1.0
CG A:ASN274 3.2 37.2 1.0
ND2 A:ASN274 3.3 37.7 1.0
P A:FGP70 3.3 84.6 1.0
CG A:ASP32 3.4 41.8 1.0
CG A:ASP31 3.6 38.4 1.0
N A:ASP32 3.6 36.8 1.0
CB A:FGP70 3.8 42.6 1.0
CA A:FGP70 4.1 36.4 1.0
O3P A:FGP70 4.1 76.8 1.0
OG1 A:FGP70 4.1 40.6 1.0
OD2 A:ASP32 4.1 43.5 1.0
C A:ASP31 4.2 38.3 1.0
CA A:ASP32 4.2 39.6 1.0
NH2 A:ARG74 4.3 41.4 1.0
CB A:ASP32 4.3 40.8 1.0
NZ A:LYS123 4.3 47.8 1.0
CA A:ASP31 4.3 37.9 1.0
OD2 A:ASP31 4.3 36.3 1.0
CB A:ASP273 4.4 32.4 1.0
N A:FGP70 4.5 34.1 1.0
O1P A:FGP70 4.5 72.9 1.0
CD2 A:HIS181 4.5 42.0 1.0
CB A:ASP31 4.6 39.0 1.0
CB A:ASN274 4.7 35.7 1.0
N A:ASN274 4.8 34.8 1.0
NE A:ARG74 4.9 35.5 1.0
CD A:ARG282 4.9 44.0 1.0

Calcium binding site 2 out of 2 in 4mhx

Go back to Calcium Binding Sites List in 4mhx
Calcium binding site 2 out of 2 in the Crystal Structure of Sulfamidase


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Crystal Structure of Sulfamidase within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ca601

b:43.5
occ:1.00
OD2 B:ASP273 2.2 27.5 1.0
OD1 B:ASP31 2.3 34.7 1.0
OD1 B:ASP32 2.3 36.4 1.0
OD1 B:ASN274 2.4 27.3 1.0
OG2 B:FGP70 2.6 47.5 1.0
O1P B:FGP70 2.9 69.0 1.0
CG B:ASP273 2.9 30.4 1.0
OD1 B:ASP273 2.9 29.4 1.0
CG B:ASN274 3.1 29.2 1.0
ND2 B:ASN274 3.2 27.3 1.0
P B:FGP70 3.4 75.1 1.0
CG B:ASP32 3.5 37.3 1.0
CG B:ASP31 3.5 38.2 1.0
N B:ASP32 3.7 34.1 1.0
CB B:FGP70 3.8 38.9 1.0
CA B:FGP70 4.0 31.6 1.0
O2P B:FGP70 4.0 61.4 1.0
C B:ASP31 4.2 35.4 1.0
OD2 B:ASP32 4.2 38.5 1.0
OG1 B:FGP70 4.3 35.9 1.0
CA B:ASP31 4.3 35.4 1.0
CA B:ASP32 4.3 36.2 1.0
CB B:ASP273 4.3 31.6 1.0
OD2 B:ASP31 4.3 39.7 1.0
NH2 B:ARG74 4.4 40.8 1.0
CB B:ASP32 4.4 36.1 1.0
NZ B:LYS123 4.4 53.7 1.0
N B:FGP70 4.4 30.1 1.0
CD2 B:HIS181 4.5 41.2 1.0
CB B:ASP31 4.5 35.3 1.0
CB B:ASN274 4.6 28.3 1.0
O3P B:FGP70 4.6 60.2 1.0
N B:ASN274 4.7 30.7 1.0
CD B:ARG282 4.9 40.6 1.0

Reference:

N.S.Sidhu, K.Schreiber, K.Proepper, S.Becker, I.Uson, G.M.Sheldrick, J.Gaertner, R.Kraetzner, R.Steinfeld. Structure of Sulfamidase Provides Insight Into the Molecular Pathology of Mucopolysaccharidosis Iiia Acta Crystallogr.,Sect.D V. D70 1321.
ISSN: ISSN 0907-4449
Page generated: Sun Jul 14 10:23:22 2024

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