Calcium in PDB 4mto: Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel

The structure of Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel, PDB code: 4mto was solved by L.Tang, T.M.Gamal El-Din, J.Payandeh, G.Q.Martinez, T.M.Heard, T.Scheuer, N.Zheng, W.A.Catterall, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.99 / 3.40
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	176.635, 177.655, 130.600, 90.00, 132.53, 90.00
R / Rfree (%)	26 / 29.7

The binding sites of Calcium atom in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel (pdb code 4mto). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 3 binding sites of Calcium where determined in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel, PDB code: 4mto:
Jump to Calcium binding site number: 1; 2; 3;

Calcium binding site 1 out of 3 in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1301 b:0.2 occ:1.00 CA A:CA1302 3.8 0.5 1.0 O C:LEU1176 4.4 78.3 1.0 OD1 B:ASP1177 4.4 64.9 1.0 O B:LEU1176 4.4 57.7 1.0 OD1 C:ASP1177 4.4 58.9 1.0 OD1 A:ASP1177 4.4 0.6 1.0 N C:ASP1178 4.5 0.3 1.0 O D:LEU1176 4.5 0.0 1.0 N D:ASP1178 4.5 94.3 1.0 OD1 D:ASP1177 4.6 0.6 1.0 N B:ASP1178 4.6 86.1 1.0 CA C:ASP1177 4.6 78.2 1.0 O A:LEU1176 4.7 83.1 1.0 CA B:ASP1177 4.8 74.3 1.0 CA D:ASP1177 4.8 0.8 1.0 N A:ASP1178 4.8 66.1 1.0 CA A:ASP1177 4.9 0.8 1.0

Calcium binding site 2 out of 3 in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1302 b:0.5 occ:1.00 CA A:CA1301 3.8 0.2 1.0 O C:THR1175 4.6 45.9 1.0 O D:LEU1176 4.7 0.0 1.0 O D:THR1175 4.8 69.7 1.0 O A:LEU1176 4.9 83.1 1.0 O C:LEU1176 4.9 78.3 1.0 O B:LEU1176 4.9 57.7 1.0 O A:THR1175 5.0 63.4 1.0

Calcium binding site 3 out of 3 in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1301 b:88.4 occ:1.00 CG D:ASP1178 3.8 0.7 1.0 CG C:ASP1178 3.8 0.2 1.0 OD1 D:ASP1178 3.9 99.0 1.0 OD1 C:ASP1178 3.9 68.7 1.0 OD2 A:ASP1178 3.9 85.8 1.0 CB C:ASP1178 4.0 94.9 1.0 OD2 D:ASP1178 4.1 0.7 1.0 CB D:ASP1178 4.1 0.1 1.0 CG A:ASP1178 4.1 0.2 1.0 CG B:ASP1178 4.2 0.2 1.0 OD2 C:ASP1178 4.2 75.8 1.0 OD1 B:ASP1178 4.3 93.2 1.0 CB B:ASP1178 4.4 0.9 1.0 CB A:ASP1178 4.5 90.8 1.0 OD2 B:ASP1178 4.6 0.5 1.0 CA C:ASP1178 4.6 85.9 1.0 OD1 A:ASP1178 4.6 0.1 1.0 CA D:ASP1178 4.7 88.7 1.0 OD1 B:ASP1177 4.8 64.9 1.0 CA B:ASP1178 4.9 87.6 1.0 N C:ASP1178 5.0 0.3 1.0

L.Tang, T.M.Gamal El-Din, J.Payandeh, G.Q.Martinez, T.M.Heard, T.Scheuer, N.Zheng, W.A.Catterall. Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel. Nature V. 505 56 2014.
ISSN: ISSN 0028-0836
PubMed: 24270805
DOI: 10.1038/NATURE12775