Calcium in PDB 4mvm: Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel

The structure of Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel, PDB code: 4mvm was solved by L.Tang, T.M.Gamal El-Din, J.Payandeh, G.Q.Martinez, T.M.Heard, T.Scheuer, N.Zheng, W.A.Catterall, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.88 / 3.20
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	177.455, 177.890, 130.890, 90.00, 132.54, 90.00
R / Rfree (%)	25.4 / 27.5

The binding sites of Calcium atom in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel (pdb code 4mvm). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 5 binding sites of Calcium where determined in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel, PDB code: 4mvm:
Jump to Calcium binding site number: 1; 2; 3; 4; 5;

Calcium binding site 1 out of 5 in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1304 b:80.6 occ:1.00 O A:HOH1402 2.3 59.0 1.0 O B:HOH1402 2.3 56.3 1.0 O C:HOH1401 2.3 61.5 1.0 O D:HOH1401 2.3 64.1 1.0 O C:HOH1402 2.3 59.3 1.0 O D:HOH1402 2.3 60.8 1.0 O A:HOH1401 2.4 60.1 1.0 O B:HOH1401 2.4 62.0 1.0 CA A:CA1305 4.0 0.8 1.0 O C:HOH1404 4.1 70.1 1.0 O A:LEU1176 4.3 57.2 1.0 O D:HOH1404 4.3 69.2 1.0 O A:HOH1404 4.3 63.9 1.0 O B:HOH1404 4.3 65.7 1.0 O B:LEU1176 4.4 58.6 1.0 N A:ASP1178 4.5 57.8 1.0 N B:ASP1178 4.5 56.3 1.0 O D:LEU1176 4.5 57.0 1.0 O C:LEU1176 4.5 56.3 1.0 OD1 D:ASP1177 4.5 58.1 1.0 OD1 C:ASP1177 4.6 62.6 1.0 CA C:CA1306 4.6 78.4 1.0 OD1 B:ASP1177 4.6 58.0 1.0 N D:ASP1178 4.6 54.9 1.0 N C:ASP1178 4.6 55.4 1.0 OD1 A:ASP1177 4.6 55.6 1.0 CA C:ASP1177 4.8 59.4 1.0 CA B:ASP1177 4.8 57.7 1.0 CA D:ASP1177 4.8 60.2 1.0 CA A:ASP1177 4.8 55.7 1.0

Calcium binding site 2 out of 5 in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1305 b:0.8 occ:1.00 O B:HOH1404 2.4 65.7 1.0 O D:HOH1404 2.4 69.2 1.0 O A:HOH1404 2.4 63.9 1.0 O C:HOH1404 2.4 70.1 1.0 O B:HOH1402 3.2 56.3 1.0 O A:HOH1402 3.3 59.0 1.0 O D:HOH1402 3.4 60.8 1.0 O C:HOH1402 3.5 59.3 1.0 CA A:CA1304 4.0 80.6 1.0 O A:LEU1176 4.8 57.2 1.0 O B:LEU1176 4.8 58.6 1.0 O B:THR1175 4.8 57.3 1.0 O D:THR1175 4.9 60.1 1.0 O D:LEU1176 4.9 57.0 1.0 O C:THR1175 4.9 58.1 1.0 O A:THR1175 4.9 55.0 1.0

Calcium binding site 3 out of 5 in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1306 b:0.4 occ:1.00 O D:HOH1405 3.4 75.3 1.0 O C:HOH1405 3.5 74.3 1.0 O B:HOH1405 3.6 64.3 1.0 CA C:CA1306 3.8 78.4 1.0 CA C:CA1307 3.8 0.3 1.0 O A:HOH1405 3.9 51.7 1.0 OD2 A:ASP1178 4.2 69.9 1.0 OD2 B:ASP1178 4.4 68.4 1.0 OD1 A:ASP1178 4.5 65.3 1.0 OD2 C:ASP1178 4.5 73.3 1.0 OD1 B:ASP1178 4.5 65.6 1.0 OD2 D:ASP1178 4.5 75.6 1.0 OD1 C:ASP1178 4.6 62.6 1.0 CG A:ASP1178 4.6 67.1 1.0 CG B:ASP1178 4.7 65.3 1.0 CG C:ASP1178 4.8 64.0 1.0 OD1 D:ASP1178 4.8 67.6 1.0 CG D:ASP1178 4.9 68.0 1.0

Calcium binding site 4 out of 5 in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca1306 b:78.4 occ:1.00 OD1 C:ASP1178 3.6 62.6 1.0 CG C:ASP1178 3.8 64.0 1.0 CA A:CA1306 3.8 0.4 1.0 O C:HOH1401 3.9 61.5 1.0 O A:HOH1401 3.9 60.1 1.0 OD1 D:ASP1178 4.0 67.6 1.0 CB C:ASP1178 4.0 51.7 1.0 CG A:ASP1178 4.0 67.1 1.0 OD1 A:ASP1178 4.1 65.3 1.0 CG D:ASP1178 4.1 68.0 1.0 O B:HOH1401 4.1 62.0 1.0 CB A:ASP1178 4.1 57.3 1.0 OD1 B:ASP1178 4.2 65.6 1.0 CB D:ASP1178 4.3 57.7 1.0 OD2 C:ASP1178 4.3 73.3 1.0 O D:HOH1401 4.3 64.1 1.0 CG B:ASP1178 4.3 65.3 1.0 OD2 A:ASP1178 4.5 69.9 1.0 CA C:ASP1178 4.5 49.9 1.0 CB B:ASP1178 4.5 59.3 1.0 O D:HOH1403 4.5 56.4 1.0 CA A:CA1304 4.6 80.6 1.0 CA D:ASP1178 4.6 57.6 1.0 OD2 D:ASP1178 4.6 75.6 1.0 CA A:ASP1178 4.6 57.4 1.0 OD1 C:ASP1177 4.7 62.6 1.0 O C:HOH1405 4.7 74.3 1.0 N C:ASP1178 4.8 55.4 1.0 O C:HOH1403 4.8 55.5 1.0 CA B:ASP1178 4.8 58.1 1.0 N D:ASP1178 4.9 54.9 1.0 N A:ASP1178 4.9 57.8 1.0 O A:HOH1403 4.9 57.0 1.0 OD2 B:ASP1178 4.9 68.4 1.0

Calcium binding site 5 out of 5 in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 5 of Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca1307 b:0.3 occ:1.00 CA A:CA1306 3.8 0.4 1.0

L.Tang, T.M.Gamal El-Din, J.Payandeh, G.Q.Martinez, T.M.Heard, T.Scheuer, N.Zheng, W.A.Catterall. Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel. Nature V. 505 56 2014.
ISSN: ISSN 0028-0836
PubMed: 24270805
DOI: 10.1038/NATURE12775