Calcium in PDB 4mvo: Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel

The structure of Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel, PDB code: 4mvo was solved by L.Tang, T.M.Gamal El-Din, J.Payandeh, G.Q.Martinez, T.M.Heard, T.Scheuer, N.Zheng, W.A.Catterall, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.85 / 3.30
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	177.475, 177.480, 130.960, 90.00, 132.63, 90.00
R / Rfree (%)	26 / 27.9

The binding sites of Calcium atom in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel (pdb code 4mvo). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 3 binding sites of Calcium where determined in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel, PDB code: 4mvo:
Jump to Calcium binding site number: 1; 2; 3;

Calcium binding site 1 out of 3 in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1307 b:90.7 occ:1.00 O A:HOH1402 3.1 40.2 1.0 O B:HOH1401 3.1 39.8 1.0 O D:HOH1401 3.4 40.2 1.0 O C:HOH1401 3.4 42.6 1.0 CA A:CA1308 3.8 55.1 1.0 O B:THR1175 4.5 43.5 1.0 O A:THR1175 4.7 42.3 1.0 CB A:LEU1176 4.9 45.0 1.0

Calcium binding site 2 out of 3 in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1308 b:55.1 occ:1.00 O B:HOH1402 2.4 40.2 1.0 O D:HOH1402 2.4 39.9 1.0 O C:HOH1402 2.4 40.5 1.0 O A:HOH1401 2.4 39.1 1.0 O C:HOH1401 2.5 42.6 1.0 O D:HOH1401 2.5 40.2 1.0 O A:HOH1402 2.5 40.2 1.0 O B:HOH1401 2.5 39.8 1.0 CA A:CA1307 3.8 90.7 1.0 O A:LEU1176 4.4 39.2 1.0 O D:LEU1176 4.5 40.3 1.0 O C:LEU1176 4.5 42.1 1.0 O B:LEU1176 4.5 40.2 1.0 OD1 B:ASP1177 4.7 45.2 1.0 CA D:ASP1177 4.8 41.2 1.0 N D:ASP1178 4.8 43.7 1.0 CA C:ASP1177 4.8 44.7 1.0 CA B:CA1304 4.9 66.3 1.0 CA B:ASP1177 4.9 42.6 1.0 OD1 A:ASP1177 4.9 49.8 1.0 OD1 C:ASP1177 4.9 51.8 1.0 N C:ASP1178 4.9 45.5 1.0 N B:ASP1178 4.9 43.4 1.0 OD1 D:ASP1177 4.9 49.9 1.0 CA A:ASP1177 4.9 43.5 1.0 N A:ASP1178 4.9 45.7 1.0

Calcium binding site 3 out of 3 in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1304 b:66.3 occ:1.00 O A:HOH1401 4.0 39.1 1.0 O B:HOH1402 4.1 40.2 1.0 O C:HOH1402 4.1 40.5 1.0 O D:HOH1402 4.1 39.9 1.0 CB D:ASP1178 4.1 44.0 1.0 CB C:ASP1178 4.2 45.7 1.0 CG B:ASP1178 4.3 52.3 1.0 CG D:ASP1178 4.3 50.2 1.0 CB B:ASP1178 4.3 43.6 1.0 CG C:ASP1178 4.3 55.0 1.0 CG A:ASP1178 4.3 53.5 1.0 CB A:ASP1178 4.3 43.4 1.0 OD1 B:ASP1178 4.3 50.5 1.0 OD1 D:ASP1178 4.4 47.5 1.0 OD1 C:ASP1178 4.5 53.2 1.0 OD1 A:ASP1178 4.5 50.1 1.0 CA D:ASP1178 4.5 43.5 1.0 CA B:ASP1178 4.5 42.4 1.0 CA C:ASP1178 4.6 44.5 1.0 OD2 B:ASP1178 4.7 56.4 1.0 CA A:ASP1178 4.7 42.8 1.0 N D:ASP1178 4.7 43.7 1.0 OD2 A:ASP1178 4.7 61.5 1.0 N B:ASP1178 4.7 43.4 1.0 OD2 D:ASP1178 4.8 54.1 1.0 OD1 D:ASP1177 4.8 49.9 1.0 OD2 C:ASP1178 4.8 62.3 1.0 OD1 C:ASP1177 4.8 51.8 1.0 N C:ASP1178 4.8 45.5 1.0 CA A:CA1308 4.9 55.1 1.0 OD1 B:ASP1177 4.9 45.2 1.0 N A:ASP1178 4.9 45.7 1.0

L.Tang, T.M.Gamal El-Din, J.Payandeh, G.Q.Martinez, T.M.Heard, T.Scheuer, N.Zheng, W.A.Catterall. Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel. Nature V. 505 56 2014.
ISSN: ISSN 0028-0836
PubMed: 24270805
DOI: 10.1038/NATURE12775