Calcium in PDB 4mvq: Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel

The structure of Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel, PDB code: 4mvq was solved by L.Tang, T.M.Gamal El-Din, J.Payandeh, Q.M.Gilbert, T.M.Heard, T.Scheuer, N.Zheng, W.A.Catterall, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	27.54 / 3.40
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	177.780, 177.725, 130.820, 90.00, 132.79, 90.00
R / Rfree (%)	28 / 31.3

The binding sites of Calcium atom in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel (pdb code 4mvq). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel, PDB code: 4mvq:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1301 b:44.4 occ:1.00 OD1 C:ASP1178 4.2 47.3 1.0 OD1 D:ASP1178 4.3 47.5 1.0 OD1 B:ASP1178 4.3 52.1 1.0 CG C:ASP1178 4.3 46.4 1.0 OD1 A:ASP1178 4.3 44.0 1.0 CG D:ASP1178 4.3 43.3 1.0 CG A:ASP1178 4.4 41.9 1.0 CG B:ASP1178 4.4 45.2 1.0 CB A:ASP1178 4.5 39.6 1.0 CB B:ASP1178 4.5 41.9 1.0 CB D:ASP1178 4.5 41.3 1.0 CB C:ASP1178 4.5 43.5 1.0 OD2 C:ASP1178 4.7 40.0 1.0 OD2 D:ASP1178 4.8 38.0 1.0 CA A:CA1302 4.8 46.1 1.0 O C:HOH1401 4.8 70.0 1.0 OD2 A:ASP1178 4.8 36.4 1.0 OD2 B:ASP1178 4.9 40.1 1.0 CA D:ASP1178 4.9 38.9 1.0 CA B:ASP1178 4.9 39.0 1.0 CA A:ASP1178 4.9 37.6 1.0 CA C:ASP1178 5.0 40.7 1.0

Calcium binding site 2 out of 2 in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1302 b:46.1 occ:1.00 OD1 C:ASP1177 4.6 51.6 1.0 O B:LEU1176 4.6 37.5 1.0 OD1 D:ASP1177 4.6 59.0 1.0 N B:ASP1178 4.7 38.9 1.0 OD1 B:ASP1177 4.7 54.4 1.0 O A:LEU1176 4.7 40.4 1.0 O D:LEU1176 4.7 40.6 1.0 N D:ASP1178 4.7 38.8 1.0 O C:LEU1176 4.7 44.9 1.0 N C:ASP1178 4.8 40.8 1.0 CA A:CA1301 4.8 44.4 1.0 OD1 A:ASP1177 4.8 54.6 1.0 N A:ASP1178 4.8 38.4 1.0 CA D:ASP1177 4.8 44.4 1.0 CA B:ASP1177 4.8 44.7 1.0 CA C:ASP1177 4.9 45.6 1.0 CA A:ASP1177 5.0 42.5 1.0

L.Tang, T.M.Gamal El-Din, J.Payandeh, G.Q.Martinez, T.M.Heard, T.Scheuer, N.Zheng, W.A.Catterall. Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel. Nature V. 505 56 2014.
ISSN: ISSN 0028-0836
PubMed: 24270805
DOI: 10.1038/NATURE12775