Calcium in PDB 4mw3: Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel

The structure of Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel, PDB code: 4mw3 was solved by L.Tang, T.M.Gamal El-Din, J.Payandeh, G.Q.Martinez, T.M.Heard, T.Scheuer, N.Zheng, W.A.Catterall, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	42.32 / 3.30
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	177.755, 178.270, 130.950, 90.00, 132.63, 90.00
R / Rfree (%)	24.9 / 26.7

The binding sites of Calcium atom in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel (pdb code 4mw3). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 3 binding sites of Calcium where determined in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel, PDB code: 4mw3:
Jump to Calcium binding site number: 1; 2; 3;

Calcium binding site 1 out of 3 in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1301 b:22.1 occ:1.00 OD1 D:ASP1178 2.3 49.8 1.0 OD1 A:ASP1178 2.4 48.8 1.0 OD1 C:ASP1178 2.4 50.0 1.0 OD1 B:ASP1178 2.6 45.8 1.0 CG D:ASP1178 3.3 42.8 1.0 CG A:ASP1178 3.4 42.2 1.0 CG C:ASP1178 3.5 40.9 1.0 CG B:ASP1178 3.6 40.1 1.0 CB A:ASP1178 4.0 24.6 1.0 OD2 D:ASP1178 4.1 53.1 1.0 CB D:ASP1178 4.2 31.9 1.0 CB C:ASP1178 4.2 25.5 1.0 OD2 A:ASP1178 4.3 49.1 1.0 CB B:ASP1178 4.4 24.1 1.0 OD2 C:ASP1178 4.5 47.3 1.0 OD2 B:ASP1178 4.5 43.8 1.0 CA A:ASP1178 4.7 21.0 1.0 CA C:ASP1178 4.7 25.1 1.0 CA B:CA1301 4.7 78.7 1.0 CA D:ASP1178 4.8 29.2 1.0 CA B:ASP1178 4.8 20.8 1.0 O A:HOH1401 4.9 28.7 1.0

Calcium binding site 2 out of 3 in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1302 b:80.2 occ:1.00 O A:HOH1401 4.1 28.7 1.0 O C:HOH1401 4.4 43.2 1.0 O B:HOH1401 4.7 34.1 1.0 O D:HOH1401 5.0 36.3 1.0

Calcium binding site 3 out of 3 in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1301 b:78.7 occ:1.00 OD1 A:ASP1177 4.1 21.8 1.0 OD1 B:ASP1177 4.3 23.0 1.0 N B:ASP1178 4.5 27.9 1.0 O D:LEU1176 4.5 20.5 1.0 OD1 C:ASP1177 4.5 20.6 1.0 N D:ASP1178 4.5 33.2 1.0 O B:LEU1176 4.6 23.5 1.0 N A:ASP1178 4.6 26.1 1.0 N C:ASP1178 4.7 33.7 1.0 CA A:CA1301 4.7 22.1 1.0 OD1 D:ASP1177 4.8 29.9 1.0 O C:LEU1176 4.9 27.6 1.0 O A:LEU1176 4.9 19.4 1.0 CA B:ASP1177 4.9 27.1 1.0

L.Tang, T.M.Gamal El-Din, J.Payandeh, G.Q.Martinez, T.M.Heard, T.Scheuer, N.Zheng, W.A.Catterall. Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel. Nature V. 505 56 2014.
ISSN: ISSN 0028-0836
PubMed: 24270805
DOI: 10.1038/NATURE12775