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Atomistry » Calcium » PDB 4n66-4nhf » 4na9 » |
Calcium in PDB 4na9: Factor Viia in Complex with the Inhibitor 3'-Amino-5'-[(2S,4R)-6- Carbamimidoyl-4-Phenyl-1,2,3,4-Tetrahydroquinolin-2-Yl]Biphenyl-2- Carboxylic AcidEnzymatic activity of Factor Viia in Complex with the Inhibitor 3'-Amino-5'-[(2S,4R)-6- Carbamimidoyl-4-Phenyl-1,2,3,4-Tetrahydroquinolin-2-Yl]Biphenyl-2- Carboxylic Acid
All present enzymatic activity of Factor Viia in Complex with the Inhibitor 3'-Amino-5'-[(2S,4R)-6- Carbamimidoyl-4-Phenyl-1,2,3,4-Tetrahydroquinolin-2-Yl]Biphenyl-2- Carboxylic Acid:
3.4.21.21; Protein crystallography data
The structure of Factor Viia in Complex with the Inhibitor 3'-Amino-5'-[(2S,4R)-6- Carbamimidoyl-4-Phenyl-1,2,3,4-Tetrahydroquinolin-2-Yl]Biphenyl-2- Carboxylic Acid, PDB code: 4na9
was solved by
A.Wei,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Calcium Binding Sites:
The binding sites of Calcium atom in the Factor Viia in Complex with the Inhibitor 3'-Amino-5'-[(2S,4R)-6- Carbamimidoyl-4-Phenyl-1,2,3,4-Tetrahydroquinolin-2-Yl]Biphenyl-2- Carboxylic Acid
(pdb code 4na9). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Factor Viia in Complex with the Inhibitor 3'-Amino-5'-[(2S,4R)-6- Carbamimidoyl-4-Phenyl-1,2,3,4-Tetrahydroquinolin-2-Yl]Biphenyl-2- Carboxylic Acid, PDB code: 4na9: Calcium binding site 1 out of 1 in 4na9Go back to Calcium Binding Sites List in 4na9
Calcium binding site 1 out
of 1 in the Factor Viia in Complex with the Inhibitor 3'-Amino-5'-[(2S,4R)-6- Carbamimidoyl-4-Phenyl-1,2,3,4-Tetrahydroquinolin-2-Yl]Biphenyl-2- Carboxylic Acid
Mono view Stereo pair view
Reference:
M.L.Quan,
P.C.Wong,
C.Wang,
F.Woerner,
J.M.Smallheer,
F.A.Barbera,
J.M.Bozarth,
R.L.Brown,
M.R.Harpel,
J.M.Luettgen,
P.E.Morin,
T.Peterson,
V.Ramamurthy,
A.R.Rendina,
K.A.Rossi,
C.A.Watson,
A.Wei,
G.Zhang,
D.Seiffert,
R.R.Wexler.
Tetrahydroquinoline Derivatives As Potent and Selective Factor Xia Inhibitors. J.Med.Chem. V. 57 955 2014.
Page generated: Sun Jul 14 10:58:46 2024
ISSN: ISSN 0022-2623 PubMed: 24405333 DOI: 10.1021/JM401670X |
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