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Calcium in PDB 4pnu: E. Coli Sliding Clamp in Complex with (R)-6-Bromo-9-(2-((R)-1-Carboxy- 2-Phenylethylamino)-2-Oxoethyl)-2,3,4,9-Tetrahydro-1H-Carbazole-2- Carboxylic Acid
Enzymatic activity of E. Coli Sliding Clamp in Complex with (R)-6-Bromo-9-(2-((R)-1-Carboxy- 2-Phenylethylamino)-2-Oxoethyl)-2,3,4,9-Tetrahydro-1H-Carbazole-2- Carboxylic Acid
All present enzymatic activity of E. Coli Sliding Clamp in Complex with (R)-6-Bromo-9-(2-((R)-1-Carboxy- 2-Phenylethylamino)-2-Oxoethyl)-2,3,4,9-Tetrahydro-1H-Carbazole-2- Carboxylic Acid:
2.7.7.7;
2.7.7.7;
Protein crystallography data
The structure of E. Coli Sliding Clamp in Complex with (R)-6-Bromo-9-(2-((R)-1-Carboxy- 2-Phenylethylamino)-2-Oxoethyl)-2,3,4,9-Tetrahydro-1H-Carbazole-2- Carboxylic Acid, PDB code: 4pnu
was solved by
Z.Yin,
A.J.Oakley,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 28.27 / 1.90 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 79.895, 67.193, 81.016, 90.00, 114.54, 90.00 |
| R / Rfree (%) | 18.2 / 23.1 |
Other elements in 4pnu:
The structure of E. Coli Sliding Clamp in Complex with (R)-6-Bromo-9-(2-((R)-1-Carboxy- 2-Phenylethylamino)-2-Oxoethyl)-2,3,4,9-Tetrahydro-1H-Carbazole-2- Carboxylic Acid also contains other interesting chemical elements:
| Bromine | (Br) | 2 atoms |
| Chlorine | (Cl) | 2 atoms |
Calcium Binding Sites:
The binding sites of Calcium atom in the E. Coli Sliding Clamp in Complex with (R)-6-Bromo-9-(2-((R)-1-Carboxy- 2-Phenylethylamino)-2-Oxoethyl)-2,3,4,9-Tetrahydro-1H-Carbazole-2- Carboxylic Acid
(pdb code 4pnu). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the E. Coli Sliding Clamp in Complex with (R)-6-Bromo-9-(2-((R)-1-Carboxy- 2-Phenylethylamino)-2-Oxoethyl)-2,3,4,9-Tetrahydro-1H-Carbazole-2- Carboxylic Acid, PDB code: 4pnu:
Jump to Calcium binding site number: 1; 2;
In total 2 binding sites of Calcium where determined in the E. Coli Sliding Clamp in Complex with (R)-6-Bromo-9-(2-((R)-1-Carboxy- 2-Phenylethylamino)-2-Oxoethyl)-2,3,4,9-Tetrahydro-1H-Carbazole-2- Carboxylic Acid, PDB code: 4pnu:
Jump to Calcium binding site number: 1; 2;
Calcium binding site 1 out of 2 in 4pnu
Go back to
Calcium Binding Sites List in 4pnu
Calcium binding site 1 out
of 2 in the E. Coli Sliding Clamp in Complex with (R)-6-Bromo-9-(2-((R)-1-Carboxy- 2-Phenylethylamino)-2-Oxoethyl)-2,3,4,9-Tetrahydro-1H-Carbazole-2- Carboxylic Acid
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Calcium with other atoms in the Ca binding
site number 1 of E. Coli Sliding Clamp in Complex with (R)-6-Bromo-9-(2-((R)-1-Carboxy- 2-Phenylethylamino)-2-Oxoethyl)-2,3,4,9-Tetrahydro-1H-Carbazole-2- Carboxylic Acid within 5.0Å range:
|
Calcium binding site 2 out of 2 in 4pnu
Go back to
Calcium Binding Sites List in 4pnu
Calcium binding site 2 out
of 2 in the E. Coli Sliding Clamp in Complex with (R)-6-Bromo-9-(2-((R)-1-Carboxy- 2-Phenylethylamino)-2-Oxoethyl)-2,3,4,9-Tetrahydro-1H-Carbazole-2- Carboxylic Acid
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Calcium with other atoms in the Ca binding
site number 2 of E. Coli Sliding Clamp in Complex with (R)-6-Bromo-9-(2-((R)-1-Carboxy- 2-Phenylethylamino)-2-Oxoethyl)-2,3,4,9-Tetrahydro-1H-Carbazole-2- Carboxylic Acid within 5.0Å range:
|
Reference:
Z.Yin,
A.J.Oakley.
Reaching Beyond the Anchor Site: Inhibitor Design Mimicking the Mechanism of Linear Motif Recognition By the E. Coli Sliding Clamp To Be Published.
Page generated: Sun Jul 14 12:09:30 2024
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