Calcium in PDB 4u91: Gephe in Complex with Para-Phenyl Crosslinked Glycine Receptor Beta Subunit Derived Dimeric Peptide

Enzymatic activity of Gephe in Complex with Para-Phenyl Crosslinked Glycine Receptor Beta Subunit Derived Dimeric Peptide

All present enzymatic activity of Gephe in Complex with Para-Phenyl Crosslinked Glycine Receptor Beta Subunit Derived Dimeric Peptide:
2.10.1.1; 2.7.7.75;

Protein crystallography data

The structure of Gephe in Complex with Para-Phenyl Crosslinked Glycine Receptor Beta Subunit Derived Dimeric Peptide, PDB code: 4u91 was solved by V.B.Kasaragod, H.M.Maric, H.Schindelin, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	20.00 / 2.00
*Space group*	I 2 2 2
*Cell size a, b, c (Å), α, β, γ (°)*	87.440, 99.210, 112.490, 90.00, 90.00, 90.00
*R / R_free (%)*	16.9 / 22.6

Calcium Binding Sites:

The binding sites of Calcium atom in the Gephe in Complex with Para-Phenyl Crosslinked Glycine Receptor Beta Subunit Derived Dimeric Peptide (pdb code 4u91). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Gephe in Complex with Para-Phenyl Crosslinked Glycine Receptor Beta Subunit Derived Dimeric Peptide, PDB code: 4u91:

Calcium binding site 1 out of 1 in 4u91

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Calcium Binding Sites List in 4u91

Calcium binding site 1 out of 1 in the Gephe in Complex with Para-Phenyl Crosslinked Glycine Receptor Beta Subunit Derived Dimeric Peptide

Mono view

Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Gephe in Complex with Para-Phenyl Crosslinked Glycine Receptor Beta Subunit Derived Dimeric Peptide within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Ca803 b:56.4 occ:1.00	O	A:HOH905	2.3	52.1	1.0
	O	A:HOH1182	2.4	52.2	1.0
	O	A:HOH945	2.4	47.8	1.0
	O	A:HOH923	2.4	49.1	1.0
	O	A:HOH988	2.4	48.8	1.0
	O	A:HOH1024	3.9	60.0	1.0
	OD1	A:ASP580	4.2	72.2	1.0
	OE2	A:GLU509	4.3	45.6	1.0
	N	A:GLY573	4.3	44.0	1.0
	OE1	A:GLU509	4.4	38.3	1.0
	OD1	A:ASP549	4.5	55.2	1.0
	O	A:HOH908	4.8	52.2	1.0
	CD	A:GLU509	4.8	38.8	1.0
	OD2	A:ASP549	4.8	47.7	1.0
	OD2	A:ASP580	4.9	61.5	1.0
	O	A:HOH1074	4.9	37.5	1.0
	CA	A:GLY573	5.0	42.6	1.0
	CA	A:GLY507	5.0	36.6	1.0
	CG	A:ASP580	5.0	64.4	1.0

Reference:

H.M.Maric, V.B.Kasaragod, L.Haugaard-Kedstrom, T.J.Hausrat, M.Kneussel, H.Schindelin, K.Strmgaard. Design and Synthesis of High-Affinity Dimeric Inhibitors Targeting the Interactions Between Gephyrin and Inhibitory Neurotransmitter Receptors. Angew.Chem.Int.Ed.Engl. 2014.
ISSN: ESSN 1521-3773
PubMed: 25413248
DOI: 10.1002/ANIE.201409043

Page generated: Sun Jul 14 13:38:01 2024

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