Calcium in PDB 4ux8: Ret Recognition of Gdnf-GFRALPHA1 Ligand By A Composite Binding Site Promotes Membrane-Proximal Self-Association
Enzymatic activity of Ret Recognition of Gdnf-GFRALPHA1 Ligand By A Composite Binding Site Promotes Membrane-Proximal Self-Association
All present enzymatic activity of Ret Recognition of Gdnf-GFRALPHA1 Ligand By A Composite Binding Site Promotes Membrane-Proximal Self-Association:
2.7.10.1;
Calcium Binding Sites:
The binding sites of Calcium atom in the Ret Recognition of Gdnf-GFRALPHA1 Ligand By A Composite Binding Site Promotes Membrane-Proximal Self-Association
(pdb code 4ux8). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total 6 binding sites of Calcium where determined in the
Ret Recognition of Gdnf-GFRALPHA1 Ligand By A Composite Binding Site Promotes Membrane-Proximal Self-Association, PDB code: 4ux8:
Jump to Calcium binding site number:
1;
2;
3;
4;
5;
6;
Calcium binding site 1 out
of 6 in 4ux8
Go back to
Calcium Binding Sites List in 4ux8
Calcium binding site 1 out
of 6 in the Ret Recognition of Gdnf-GFRALPHA1 Ligand By A Composite Binding Site Promotes Membrane-Proximal Self-Association
Mono view
Stereo pair view
|
A full contact list of Calcium with other atoms in the Ca binding
site number 1 of Ret Recognition of Gdnf-GFRALPHA1 Ligand By A Composite Binding Site Promotes Membrane-Proximal Self-Association within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Ca1603
b:10.5
occ:1.00
|
O
|
A:GLU265
|
2.3
|
30.5
|
1.0
|
OD1
|
A:ASP267
|
2.5
|
10.1
|
1.0
|
OE2
|
A:GLU178
|
2.6
|
40.2
|
1.0
|
OD2
|
A:ASP264
|
2.7
|
47.1
|
1.0
|
OD1
|
A:ASP264
|
2.9
|
47.1
|
1.0
|
CG
|
A:ASP264
|
3.0
|
47.1
|
1.0
|
C
|
A:GLU265
|
3.5
|
30.5
|
1.0
|
N
|
A:GLU265
|
3.6
|
30.5
|
1.0
|
OD1
|
A:ASP302
|
3.6
|
93.3
|
1.0
|
CG
|
A:ASP267
|
3.7
|
10.1
|
1.0
|
CD
|
A:GLU178
|
3.8
|
39.3
|
1.0
|
CA
|
A:GLU265
|
4.1
|
30.5
|
1.0
|
N
|
A:ASP267
|
4.2
|
48.2
|
1.0
|
CG
|
A:ASP302
|
4.2
|
93.3
|
1.0
|
CB
|
A:ASP267
|
4.4
|
10.1
|
1.0
|
CB
|
A:ASP264
|
4.4
|
47.1
|
1.0
|
CB
|
A:ASP302
|
4.4
|
93.3
|
1.0
|
C
|
A:ASP264
|
4.6
|
43.1
|
1.0
|
OD2
|
A:ASP267
|
4.6
|
10.1
|
1.0
|
N
|
A:ASP266
|
4.6
|
34.3
|
1.0
|
OE1
|
A:GLU178
|
4.6
|
39.4
|
1.0
|
CA
|
A:ASP264
|
4.6
|
43.1
|
1.0
|
CG
|
A:GLU178
|
4.8
|
40.6
|
1.0
|
CB
|
A:ARG231
|
4.8
|
47.0
|
1.0
|
CA
|
A:CA1604
|
4.8
|
12.9
|
1.0
|
CB
|
A:GLU265
|
4.8
|
20.0
|
1.0
|
CD
|
A:ARG231
|
4.8
|
50.1
|
1.0
|
CA
|
A:ASP302
|
4.8
|
93.3
|
1.0
|
N
|
A:VAL303
|
4.8
|
58.3
|
1.0
|
CA
|
A:ASP267
|
4.9
|
48.2
|
1.0
|
CA
|
A:ASP266
|
4.9
|
34.3
|
1.0
|
|
Calcium binding site 2 out
of 6 in 4ux8
Go back to
Calcium Binding Sites List in 4ux8
Calcium binding site 2 out
of 6 in the Ret Recognition of Gdnf-GFRALPHA1 Ligand By A Composite Binding Site Promotes Membrane-Proximal Self-Association
Mono view
Stereo pair view
|
A full contact list of Calcium with other atoms in the Ca binding
site number 2 of Ret Recognition of Gdnf-GFRALPHA1 Ligand By A Composite Binding Site Promotes Membrane-Proximal Self-Association within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Ca1604
b:12.9
occ:1.00
|
OD1
|
A:ASP230
|
2.0
|
54.0
|
1.0
|
OD2
|
A:ASP267
|
2.4
|
10.1
|
1.0
|
CG
|
A:ASP267
|
2.6
|
10.1
|
1.0
|
CB
|
A:GLU232
|
2.7
|
50.5
|
1.0
|
CG
|
A:ASP230
|
2.8
|
52.0
|
1.0
|
N
|
A:GLU232
|
2.9
|
49.3
|
1.0
|
CB
|
A:ASP267
|
3.1
|
10.1
|
1.0
|
OE1
|
A:GLU178
|
3.2
|
39.4
|
1.0
|
OD1
|
A:ASP267
|
3.2
|
10.1
|
1.0
|
OD2
|
A:ASP230
|
3.2
|
57.2
|
1.0
|
CA
|
A:GLU232
|
3.4
|
49.9
|
1.0
|
N
|
A:ARG231
|
3.8
|
45.5
|
1.0
|
CD
|
A:GLU178
|
3.8
|
39.3
|
1.0
|
OE2
|
A:GLU178
|
3.9
|
40.2
|
1.0
|
C
|
A:ASP230
|
4.0
|
45.0
|
1.0
|
CB
|
A:ASP230
|
4.0
|
47.5
|
1.0
|
C
|
A:ARG231
|
4.1
|
49.2
|
1.0
|
CA
|
A:ASP230
|
4.2
|
46.8
|
1.0
|
C
|
A:GLU232
|
4.4
|
50.2
|
1.0
|
CA
|
A:ARG231
|
4.4
|
46.9
|
1.0
|
N
|
A:GLN233
|
4.5
|
49.1
|
1.0
|
O
|
A:ASP230
|
4.6
|
44.7
|
1.0
|
CA
|
A:ASP267
|
4.6
|
48.2
|
1.0
|
CA
|
A:CA1603
|
4.8
|
10.5
|
1.0
|
CB
|
A:ARG231
|
4.9
|
47.0
|
1.0
|
|
Calcium binding site 3 out
of 6 in 4ux8
Go back to
Calcium Binding Sites List in 4ux8
Calcium binding site 3 out
of 6 in the Ret Recognition of Gdnf-GFRALPHA1 Ligand By A Composite Binding Site Promotes Membrane-Proximal Self-Association
Mono view
Stereo pair view
|
A full contact list of Calcium with other atoms in the Ca binding
site number 3 of Ret Recognition of Gdnf-GFRALPHA1 Ligand By A Composite Binding Site Promotes Membrane-Proximal Self-Association within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Ca1605
b:10.5
occ:1.00
|
OD2
|
A:ASP302
|
1.9
|
93.3
|
1.0
|
O
|
A:SER268
|
2.3
|
65.3
|
1.0
|
NH1
|
A:ARG360
|
2.6
|
0.5
|
1.0
|
OD1
|
A:ASP266
|
2.6
|
20.0
|
1.0
|
O
|
A:GLY308
|
2.8
|
49.4
|
1.0
|
OD2
|
A:ASP300
|
3.0
|
92.6
|
1.0
|
CG
|
A:ASP302
|
3.0
|
93.3
|
1.0
|
C
|
A:GLY308
|
3.2
|
49.4
|
1.0
|
C
|
A:SER268
|
3.3
|
65.3
|
1.0
|
OG
|
A:SER268
|
3.3
|
20.0
|
1.0
|
OD1
|
A:ASP300
|
3.6
|
92.6
|
1.0
|
CA
|
A:GLY308
|
3.6
|
49.4
|
1.0
|
CG
|
A:ASP300
|
3.6
|
92.6
|
1.0
|
CG
|
A:ASP266
|
3.6
|
20.0
|
1.0
|
CZ
|
A:ARG360
|
3.7
|
0.5
|
1.0
|
CB
|
A:ASP302
|
3.8
|
93.3
|
1.0
|
N
|
A:GLU309
|
4.0
|
0.8
|
1.0
|
CA
|
A:SER268
|
4.0
|
65.3
|
1.0
|
OD1
|
A:ASP302
|
4.0
|
93.3
|
1.0
|
N
|
A:SER268
|
4.2
|
65.3
|
1.0
|
OD2
|
A:ASP266
|
4.2
|
20.0
|
1.0
|
CB
|
A:SER268
|
4.2
|
20.0
|
1.0
|
N
|
A:ALA269
|
4.3
|
45.7
|
1.0
|
NH2
|
A:ARG360
|
4.3
|
0.5
|
1.0
|
CA
|
A:GLU309
|
4.4
|
0.8
|
1.0
|
CA
|
A:ASP266
|
4.4
|
34.3
|
1.0
|
CB
|
A:ASP266
|
4.5
|
20.0
|
1.0
|
CA
|
A:ALA269
|
4.6
|
45.7
|
1.0
|
C
|
A:ASP266
|
4.7
|
34.3
|
1.0
|
NE
|
A:ARG360
|
4.7
|
0.5
|
1.0
|
CD
|
A:ARG360
|
4.8
|
0.5
|
1.0
|
O
|
A:ASP266
|
4.8
|
34.3
|
1.0
|
CB
|
A:ASP300
|
4.9
|
92.6
|
1.0
|
C
|
A:ALA269
|
4.9
|
45.7
|
1.0
|
N
|
A:GLY308
|
5.0
|
49.4
|
1.0
|
|
Calcium binding site 4 out
of 6 in 4ux8
Go back to
Calcium Binding Sites List in 4ux8
Calcium binding site 4 out
of 6 in the Ret Recognition of Gdnf-GFRALPHA1 Ligand By A Composite Binding Site Promotes Membrane-Proximal Self-Association
Mono view
Stereo pair view
|
A full contact list of Calcium with other atoms in the Ca binding
site number 4 of Ret Recognition of Gdnf-GFRALPHA1 Ligand By A Composite Binding Site Promotes Membrane-Proximal Self-Association within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Ca1603
b:10.5
occ:1.00
|
O
|
B:GLU265
|
2.3
|
30.5
|
1.0
|
OD1
|
B:ASP267
|
2.5
|
10.1
|
1.0
|
OE2
|
B:GLU178
|
2.6
|
40.2
|
1.0
|
OD2
|
B:ASP264
|
2.7
|
47.1
|
1.0
|
OD1
|
B:ASP264
|
2.9
|
47.1
|
1.0
|
CG
|
B:ASP264
|
3.0
|
47.1
|
1.0
|
C
|
B:GLU265
|
3.5
|
30.5
|
1.0
|
N
|
B:GLU265
|
3.6
|
30.5
|
1.0
|
OD1
|
B:ASP302
|
3.6
|
93.3
|
1.0
|
CG
|
B:ASP267
|
3.7
|
10.1
|
1.0
|
CD
|
B:GLU178
|
3.8
|
39.3
|
1.0
|
CA
|
B:GLU265
|
4.1
|
30.5
|
1.0
|
N
|
B:ASP267
|
4.2
|
48.2
|
1.0
|
CG
|
B:ASP302
|
4.2
|
93.3
|
1.0
|
CB
|
B:ASP267
|
4.4
|
10.1
|
1.0
|
CB
|
B:ASP264
|
4.4
|
47.1
|
1.0
|
CB
|
B:ASP302
|
4.4
|
93.3
|
1.0
|
C
|
B:ASP264
|
4.6
|
43.1
|
1.0
|
OD2
|
B:ASP267
|
4.6
|
10.1
|
1.0
|
N
|
B:ASP266
|
4.6
|
34.3
|
1.0
|
OE1
|
B:GLU178
|
4.6
|
39.4
|
1.0
|
CA
|
B:ASP264
|
4.6
|
43.1
|
1.0
|
CG
|
B:GLU178
|
4.8
|
40.6
|
1.0
|
CB
|
B:ARG231
|
4.8
|
47.0
|
1.0
|
CA
|
B:CA1604
|
4.8
|
12.9
|
1.0
|
CB
|
B:GLU265
|
4.8
|
20.0
|
1.0
|
CD
|
B:ARG231
|
4.8
|
50.1
|
1.0
|
CA
|
B:ASP302
|
4.8
|
93.3
|
1.0
|
N
|
B:VAL303
|
4.8
|
58.3
|
1.0
|
CA
|
B:ASP267
|
4.9
|
48.2
|
1.0
|
CA
|
B:ASP266
|
4.9
|
34.3
|
1.0
|
|
Calcium binding site 5 out
of 6 in 4ux8
Go back to
Calcium Binding Sites List in 4ux8
Calcium binding site 5 out
of 6 in the Ret Recognition of Gdnf-GFRALPHA1 Ligand By A Composite Binding Site Promotes Membrane-Proximal Self-Association
Mono view
Stereo pair view
|
A full contact list of Calcium with other atoms in the Ca binding
site number 5 of Ret Recognition of Gdnf-GFRALPHA1 Ligand By A Composite Binding Site Promotes Membrane-Proximal Self-Association within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Ca1604
b:12.9
occ:1.00
|
OD1
|
B:ASP230
|
2.0
|
54.0
|
1.0
|
OD2
|
B:ASP267
|
2.4
|
10.1
|
1.0
|
CG
|
B:ASP267
|
2.6
|
10.1
|
1.0
|
CB
|
B:GLU232
|
2.7
|
50.5
|
1.0
|
CG
|
B:ASP230
|
2.8
|
52.0
|
1.0
|
N
|
B:GLU232
|
2.9
|
49.3
|
1.0
|
CB
|
B:ASP267
|
3.1
|
10.1
|
1.0
|
OE1
|
B:GLU178
|
3.2
|
39.4
|
1.0
|
OD1
|
B:ASP267
|
3.2
|
10.1
|
1.0
|
OD2
|
B:ASP230
|
3.2
|
57.2
|
1.0
|
CA
|
B:GLU232
|
3.4
|
49.9
|
1.0
|
N
|
B:ARG231
|
3.8
|
45.5
|
1.0
|
CD
|
B:GLU178
|
3.8
|
39.3
|
1.0
|
OE2
|
B:GLU178
|
3.9
|
40.2
|
1.0
|
C
|
B:ASP230
|
4.0
|
45.0
|
1.0
|
CB
|
B:ASP230
|
4.0
|
47.5
|
1.0
|
C
|
B:ARG231
|
4.1
|
49.2
|
1.0
|
CA
|
B:ASP230
|
4.2
|
46.8
|
1.0
|
CA
|
B:ARG231
|
4.4
|
46.9
|
1.0
|
C
|
B:GLU232
|
4.4
|
50.2
|
1.0
|
N
|
B:GLN233
|
4.5
|
49.1
|
1.0
|
O
|
B:ASP230
|
4.6
|
44.7
|
1.0
|
CA
|
B:ASP267
|
4.6
|
48.2
|
1.0
|
CA
|
B:CA1603
|
4.8
|
10.5
|
1.0
|
CB
|
B:ARG231
|
4.9
|
47.0
|
1.0
|
|
Calcium binding site 6 out
of 6 in 4ux8
Go back to
Calcium Binding Sites List in 4ux8
Calcium binding site 6 out
of 6 in the Ret Recognition of Gdnf-GFRALPHA1 Ligand By A Composite Binding Site Promotes Membrane-Proximal Self-Association
Mono view
Stereo pair view
|
A full contact list of Calcium with other atoms in the Ca binding
site number 6 of Ret Recognition of Gdnf-GFRALPHA1 Ligand By A Composite Binding Site Promotes Membrane-Proximal Self-Association within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Ca1605
b:10.5
occ:1.00
|
OD2
|
B:ASP302
|
1.9
|
93.3
|
1.0
|
O
|
B:SER268
|
2.3
|
65.3
|
1.0
|
NH1
|
B:ARG360
|
2.6
|
0.5
|
1.0
|
OD1
|
B:ASP266
|
2.6
|
20.0
|
1.0
|
O
|
B:GLY308
|
2.8
|
49.4
|
1.0
|
OD2
|
B:ASP300
|
3.0
|
92.6
|
1.0
|
CG
|
B:ASP302
|
3.0
|
93.3
|
1.0
|
C
|
B:GLY308
|
3.2
|
49.4
|
1.0
|
C
|
B:SER268
|
3.3
|
65.3
|
1.0
|
OG
|
B:SER268
|
3.3
|
20.0
|
1.0
|
OD1
|
B:ASP300
|
3.6
|
92.6
|
1.0
|
CA
|
B:GLY308
|
3.6
|
49.4
|
1.0
|
CG
|
B:ASP300
|
3.6
|
92.6
|
1.0
|
CG
|
B:ASP266
|
3.6
|
20.0
|
1.0
|
CZ
|
B:ARG360
|
3.7
|
0.5
|
1.0
|
CB
|
B:ASP302
|
3.8
|
93.3
|
1.0
|
N
|
B:GLU309
|
4.0
|
0.8
|
1.0
|
CA
|
B:SER268
|
4.0
|
65.3
|
1.0
|
OD1
|
B:ASP302
|
4.0
|
93.3
|
1.0
|
N
|
B:SER268
|
4.2
|
65.3
|
1.0
|
OD2
|
B:ASP266
|
4.2
|
20.0
|
1.0
|
CB
|
B:SER268
|
4.2
|
20.0
|
1.0
|
N
|
B:ALA269
|
4.3
|
45.7
|
1.0
|
NH2
|
B:ARG360
|
4.3
|
0.5
|
1.0
|
CA
|
B:GLU309
|
4.4
|
0.8
|
1.0
|
CA
|
B:ASP266
|
4.4
|
34.3
|
1.0
|
CB
|
B:ASP266
|
4.5
|
20.0
|
1.0
|
CA
|
B:ALA269
|
4.6
|
45.7
|
1.0
|
C
|
B:ASP266
|
4.7
|
34.3
|
1.0
|
NE
|
B:ARG360
|
4.7
|
0.5
|
1.0
|
CD
|
B:ARG360
|
4.8
|
0.5
|
1.0
|
O
|
B:ASP266
|
4.8
|
34.3
|
1.0
|
CB
|
B:ASP300
|
4.9
|
92.6
|
1.0
|
C
|
B:ALA269
|
4.9
|
45.7
|
1.0
|
N
|
B:GLY308
|
5.0
|
49.4
|
1.0
|
|
Reference:
K.M.Goodman,
S.Kjaer,
F.Beuron,
P.P.Knowles,
A.Nawrotek,
E.M.Burns,
A.G.Purkiss,
R.George,
M.Santoro,
E.P.Morris,
N.Q.Mcdonald.
Ret Recognition of Gdnf-GFRALPHA1 Ligand By A Composite Binding Site Promotes Membrane-Proximal Self-Association. Cell Rep. V. 8 1894 2014.
ISSN: ISSN 2211-1247
PubMed: 25242331
DOI: 10.1016/J.CELREP.2014.08.040
Page generated: Sun Jul 14 13:51:50 2024
|