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Calcium in PDB 4x8c: Crystal Structure of Human Peptidylarginine Deiminase TYPE4 (PAD4) in Complex with GSK147Enzymatic activity of Crystal Structure of Human Peptidylarginine Deiminase TYPE4 (PAD4) in Complex with GSK147
All present enzymatic activity of Crystal Structure of Human Peptidylarginine Deiminase TYPE4 (PAD4) in Complex with GSK147:
3.5.3.15; Protein crystallography data
The structure of Crystal Structure of Human Peptidylarginine Deiminase TYPE4 (PAD4) in Complex with GSK147, PDB code: 4x8c
was solved by
H.D.Lewis,
B.D.Bax,
C.-W.Chung,
O.Polyakova,
J.Thorpe,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Calcium Binding Sites:
The binding sites of Calcium atom in the Crystal Structure of Human Peptidylarginine Deiminase TYPE4 (PAD4) in Complex with GSK147
(pdb code 4x8c). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Crystal Structure of Human Peptidylarginine Deiminase TYPE4 (PAD4) in Complex with GSK147, PDB code: 4x8c: Jump to Calcium binding site number: 1; 2; Calcium binding site 1 out of 2 in 4x8cGo back to Calcium Binding Sites List in 4x8c
Calcium binding site 1 out
of 2 in the Crystal Structure of Human Peptidylarginine Deiminase TYPE4 (PAD4) in Complex with GSK147
Mono view Stereo pair view
Calcium binding site 2 out of 2 in 4x8cGo back to Calcium Binding Sites List in 4x8c
Calcium binding site 2 out
of 2 in the Crystal Structure of Human Peptidylarginine Deiminase TYPE4 (PAD4) in Complex with GSK147
Mono view Stereo pair view
Reference:
H.D.Lewis,
J.Liddle,
J.E.Coote,
S.J.Atkinson,
M.D.Barker,
B.D.Bax,
K.L.Bicker,
R.P.Bingham,
M.Campbell,
Y.H.Chen,
C.W.Chung,
P.D.Craggs,
R.P.Davis,
D.Eberhard,
G.Joberty,
K.E.Lind,
K.Locke,
C.Maller,
K.Martinod,
C.Patten,
O.Polyakova,
C.E.Rise,
M.Rudiger,
R.J.Sheppard,
D.J.Slade,
P.Thomas,
J.Thorpe,
G.Yao,
G.Drewes,
D.D.Wagner,
P.R.Thompson,
R.K.Prinjha,
D.M.Wilson.
Inhibition of PAD4 Activity Is Sufficient to Disrupt Mouse and Human Net Formation. Nat.Chem.Biol. 2015.
Page generated: Sat Dec 12 05:11:43 2020
ISSN: ESSN 1552-4469 PubMed: 25622091 DOI: 10.1038/NCHEMBIO.1735 |
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