Calcium in PDB 4x9p: Crystal Structure of Bovine Annexin A2

The structure of Crystal Structure of Bovine Annexin A2, PDB code: 4x9p was solved by I.A.Shumilin, H.Hollas, A.Vedeler, R.H.Kretsinger, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 2.01
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	48.315, 63.274, 117.334, 90.00, 90.00, 90.00
R / Rfree (%)	15.7 / 20.9

The structure of Crystal Structure of Bovine Annexin A2 also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Calcium atom in the Crystal Structure of Bovine Annexin A2 (pdb code 4x9p). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 3 binding sites of Calcium where determined in the Crystal Structure of Bovine Annexin A2, PDB code: 4x9p:
Jump to Calcium binding site number: 1; 2; 3;

Calcium binding site 1 out of 3 in the Crystal Structure of Bovine Annexin A2


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of Bovine Annexin A2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca401 b:33.0 occ:1.00 O A:HOH567 2.3 41.5 1.0 O A:GLY280 2.4 38.0 1.0 O A:MET278 2.5 33.2 1.0 O A:GLY282 2.5 35.0 1.0 OD2 A:ASP322 2.6 38.5 1.0 OD1 A:ASP322 2.6 41.1 1.0 CG A:ASP322 2.9 38.9 1.0 C A:GLY282 3.5 36.1 1.0 C A:MET278 3.5 33.6 1.0 C A:GLY280 3.6 41.2 1.0 N A:GLY282 3.8 34.1 1.0 CA A:GLY282 4.0 36.7 1.0 CA A:MET278 4.1 29.2 1.0 C A:LYS281 4.1 37.0 1.0 C A:LYS279 4.2 42.4 1.0 O A:LYS279 4.2 48.5 1.0 N A:GLY280 4.3 43.7 1.0 OG1 A:THR283 4.3 35.7 1.0 CB A:ASP322 4.3 33.2 1.0 N A:LYS279 4.5 37.9 1.0 N A:LYS281 4.5 38.0 1.0 N A:THR283 4.6 34.0 1.0 CA A:LYS281 4.6 39.7 1.0 O A:LYS281 4.6 37.2 1.0 CA A:GLY280 4.6 44.3 1.0 CB A:MET278 4.6 29.6 1.0 CA A:LYS279 4.7 43.1 1.0 CA A:THR283 4.9 34.3 1.0 CA A:ASP322 5.0 32.4 1.0

Calcium binding site 2 out of 3 in the Crystal Structure of Bovine Annexin A2


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Crystal Structure of Bovine Annexin A2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca402 b:58.5 occ:1.00 O A:ARG205 2.3 61.4 1.0 O A:GLY207 2.5 55.4 1.0 O A:GLY202 2.5 45.6 1.0 OE1 A:GLU247 2.6 52.5 1.0 O A:HOH749 2.6 57.2 1.0 OE2 A:GLU247 2.8 50.4 1.0 CD A:GLU247 3.0 50.9 1.0 C A:GLY202 3.4 44.7 1.0 O A:LYS206 3.4 73.8 1.0 C A:ARG205 3.5 66.5 1.0 C A:GLY207 3.6 60.0 1.0 C A:LYS206 3.7 67.7 1.0 OG1 A:THR208 4.1 48.6 1.0 N A:GLY207 4.2 64.7 1.0 CA A:GLY202 4.2 42.0 1.0 CA A:LYS206 4.2 70.5 1.0 N A:VAL203 4.2 48.5 1.0 N A:LYS206 4.3 68.6 1.0 N A:ARG205 4.3 61.2 1.0 CA A:GLY207 4.4 62.5 1.0 CA A:VAL203 4.4 49.3 1.0 CG A:ARG205 4.5 62.5 1.0 CA A:ARG205 4.5 64.0 1.0 CG A:GLU247 4.5 46.4 1.0 N A:THR208 4.6 54.6 1.0 C A:VAL203 4.6 53.5 1.0 O A:VAL203 4.7 51.6 1.0 CA A:THR208 4.8 51.0 1.0

Calcium binding site 3 out of 3 in the Crystal Structure of Bovine Annexin A2


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Crystal Structure of Bovine Annexin A2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca403 b:62.5 occ:1.00 OE1 A:GLU53 2.4 49.5 1.0 O A:VAL51 2.5 36.0 1.0 O A:GLY50 2.5 40.3 1.0 C A:GLY50 3.5 42.6 1.0 CD A:GLU53 3.6 47.6 1.0 C A:VAL51 3.6 36.1 1.0 O A:HOH686 4.1 52.9 1.0 N A:VAL51 4.2 40.0 1.0 CA A:VAL51 4.2 37.6 1.0 O A:HOH685 4.2 46.8 1.0 CB A:VAL51 4.4 37.8 1.0 OE2 A:GLU53 4.4 47.4 1.0 CA A:GLY50 4.4 45.8 1.0 CG A:GLU53 4.4 39.1 1.0 N A:GLU53 4.6 31.9 1.0 N A:ASP52 4.7 34.1 1.0 CB A:GLU53 4.9 35.4 1.0

A.Raddum, H.Hollas, I.A.Shumilin, P.Henklein, R.H.Kretsinger, T.Fossen, A.Vedeler. The Native Structure of Annexin A2 Peptides in Hydrophilic Environment Determines Their Anti-Angiogenic Effects To Be Published.