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Calcium in PDB 4xct: Crystal Structure of A Hydroxamate Based Inhibitor ARP101 (EN73) in Complex with the Mmp-9 Catalytic Domain.
Enzymatic activity of Crystal Structure of A Hydroxamate Based Inhibitor ARP101 (EN73) in Complex with the Mmp-9 Catalytic Domain.
All present enzymatic activity of Crystal Structure of A Hydroxamate Based Inhibitor ARP101 (EN73) in Complex with the Mmp-9 Catalytic Domain.:
3.4.24.35;
3.4.24.35;
Protein crystallography data
The structure of Crystal Structure of A Hydroxamate Based Inhibitor ARP101 (EN73) in Complex with the Mmp-9 Catalytic Domain., PDB code: 4xct
was solved by
E.A.Stura,
L.Tepshi,
E.Nuti,
V.Dive,
E.Cassar-Lajeunesse,
L.Vera,
A.Rossello,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 34.30 / 1.30 |
| Space group | P 32 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 39.600, 39.600, 163.960, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 16.7 / 23.1 |
Other elements in 4xct:
The structure of Crystal Structure of A Hydroxamate Based Inhibitor ARP101 (EN73) in Complex with the Mmp-9 Catalytic Domain. also contains other interesting chemical elements:
| Zinc | (Zn) | 2 atoms |
Calcium Binding Sites:
The binding sites of Calcium atom in the Crystal Structure of A Hydroxamate Based Inhibitor ARP101 (EN73) in Complex with the Mmp-9 Catalytic Domain.
(pdb code 4xct). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total 3 binding sites of Calcium where determined in the Crystal Structure of A Hydroxamate Based Inhibitor ARP101 (EN73) in Complex with the Mmp-9 Catalytic Domain., PDB code: 4xct:
Jump to Calcium binding site number: 1; 2; 3;
In total 3 binding sites of Calcium where determined in the Crystal Structure of A Hydroxamate Based Inhibitor ARP101 (EN73) in Complex with the Mmp-9 Catalytic Domain., PDB code: 4xct:
Jump to Calcium binding site number: 1; 2; 3;
Calcium binding site 1 out of 3 in 4xct
Go back to
Calcium Binding Sites List in 4xct
Calcium binding site 1 out
of 3 in the Crystal Structure of A Hydroxamate Based Inhibitor ARP101 (EN73) in Complex with the Mmp-9 Catalytic Domain.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Calcium with other atoms in the Ca binding
site number 1 of Crystal Structure of A Hydroxamate Based Inhibitor ARP101 (EN73) in Complex with the Mmp-9 Catalytic Domain. within 5.0Å range:
|
Calcium binding site 2 out of 3 in 4xct
Go back to
Calcium Binding Sites List in 4xct
Calcium binding site 2 out
of 3 in the Crystal Structure of A Hydroxamate Based Inhibitor ARP101 (EN73) in Complex with the Mmp-9 Catalytic Domain.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Calcium with other atoms in the Ca binding
site number 2 of Crystal Structure of A Hydroxamate Based Inhibitor ARP101 (EN73) in Complex with the Mmp-9 Catalytic Domain. within 5.0Å range:
|
Calcium binding site 3 out of 3 in 4xct
Go back to
Calcium Binding Sites List in 4xct
Calcium binding site 3 out
of 3 in the Crystal Structure of A Hydroxamate Based Inhibitor ARP101 (EN73) in Complex with the Mmp-9 Catalytic Domain.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Calcium with other atoms in the Ca binding
site number 3 of Crystal Structure of A Hydroxamate Based Inhibitor ARP101 (EN73) in Complex with the Mmp-9 Catalytic Domain. within 5.0Å range:
|
Reference:
E.Nuti,
C.Camodeca,
A.R.Cantelmo,
T.Tuccinardi,
L.Vera,
L.Tepshi,
E.Orlandini,
S.Nencetti,
E.A.Stura,
A.Albini,
A.Martinelli,
V.Dive,
A.Rossello.
N-O-Isopropyl Sulphonamido-Based Hydroxamates As Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic Activity. Journal of Medicinalchemistry.
Page generated: Sun Jul 14 14:33:00 2024
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