Calcium in PDB 4y93: Crystal Structure of the pH-Th-Kinase Construct of Bruton'S Tyrosine Kinase (Btk)

Enzymatic activity of Crystal Structure of the pH-Th-Kinase Construct of Bruton'S Tyrosine Kinase (Btk)

All present enzymatic activity of Crystal Structure of the pH-Th-Kinase Construct of Bruton'S Tyrosine Kinase (Btk):
2.7.10.2;

Protein crystallography data

The structure of Crystal Structure of the pH-Th-Kinase Construct of Bruton'S Tyrosine Kinase (Btk), PDB code: 4y93 was solved by Q.Wang, J.Kuriyan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	43.68 / 1.70
*Space group*	P 2 2₁ 2₁
*Cell size a, b, c (Å), α, β, γ (°)*	38.328, 78.647, 157.569, 90.00, 90.00, 90.00
*R / R_free (%)*	15.7 / 19.5

Other elements in 4y93:

The structure of Crystal Structure of the pH-Th-Kinase Construct of Bruton'S Tyrosine Kinase (Btk) also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

Calcium Binding Sites:

The binding sites of Calcium atom in the Crystal Structure of the pH-Th-Kinase Construct of Bruton'S Tyrosine Kinase (Btk) (pdb code 4y93). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Crystal Structure of the pH-Th-Kinase Construct of Bruton'S Tyrosine Kinase (Btk), PDB code: 4y93:

Calcium binding site 1 out of 1 in 4y93

Go back to

Calcium Binding Sites List in 4y93

Calcium binding site 1 out of 1 in the Crystal Structure of the pH-Th-Kinase Construct of Bruton'S Tyrosine Kinase (Btk)

Mono view

Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of the pH-Th-Kinase Construct of Bruton'S Tyrosine Kinase (Btk) within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Ca703 b:14.6 occ:1.00	O	A:HOH885	2.4	15.6	1.0
	OD1	A:ASN479	2.4	12.5	1.0
	O	A:HOH877	2.5	15.9	1.0
	O	A:HOH866	2.5	17.7	1.0
	HA	A:ASN479	3.2	11.8	1.0
	CG	A:ASN479	3.6	13.4	1.0
	HH22	A:ARG490	3.6	16.5	1.0
	CA	A:ASN479	4.1	9.8	1.0
	CB	A:ASN479	4.3	11.2	1.0
	HB3	A:ASN479	4.3	13.4	1.0
	O	A:ALA478	4.4	11.7	1.0
	NH2	A:ARG490	4.4	13.8	1.0
	O	A:ASN479	4.5	13.7	1.0
	HH21	A:ARG490	4.5	16.5	1.0
	C	A:ASN479	4.6	11.8	1.0
	ND2	A:ASN479	4.6	13.5	1.0
	OE1	A:GLU488	4.7	17.5	1.0
	OE2	A:GLU488	4.7	25.6	1.0
	HD21	A:ASN479	4.7	16.2	1.0
	HE1	A:TYR485	4.8	20.1	1.0
	HD1	A:TYR485	4.8	20.7	1.0
	O	A:HOH932	4.8	20.7	1.0

Reference:

Q.Wang, E.M.Vogan, L.M.Nocka, C.E.Rosen, J.A.Zorn, S.C.Harrison, J.Kuriyan. Autoinhibition of Bruton'S Tyrosine Kinase (Btk) and Activation By Soluble Inositol Hexakisphosphate. Elife V. 4 2015.
ISSN: ESSN 2050-084X
PubMed: 25699547
DOI: 10.7554/ELIFE.06074

Page generated: Sun Jul 14 14:50:46 2024

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