Calcium in PDB 4zma: Crystal Structure of A Fviia-Trypsin Chimera (St) in Complex with Soluble Tissue Factor
Enzymatic activity of Crystal Structure of A Fviia-Trypsin Chimera (St) in Complex with Soluble Tissue Factor
All present enzymatic activity of Crystal Structure of A Fviia-Trypsin Chimera (St) in Complex with Soluble Tissue Factor:
3.4.21.21;
Protein crystallography data
The structure of Crystal Structure of A Fviia-Trypsin Chimera (St) in Complex with Soluble Tissue Factor, PDB code: 4zma
was solved by
A.B.Sorensen,
L.A.Svensson,
P.S.Gandhi,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
|
Resolution Low / High (Å)
|
29.77 /
2.30
|
|
Space group
|
P 21 21 21
|
|
Cell size a, b, c (Å), α, β, γ (°)
|
66.209,
80.898,
125.759,
90.00,
90.00,
90.00
|
|
R / Rfree (%)
|
24 /
29.5
|
Other elements in 4zma:
The structure of Crystal Structure of A Fviia-Trypsin Chimera (St) in Complex with Soluble Tissue Factor also contains other interesting chemical elements:
Calcium Binding Sites:
The binding sites of Calcium atom in the Crystal Structure of A Fviia-Trypsin Chimera (St) in Complex with Soluble Tissue Factor
(pdb code 4zma). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total 8 binding sites of Calcium where determined in the
Crystal Structure of A Fviia-Trypsin Chimera (St) in Complex with Soluble Tissue Factor, PDB code: 4zma:
Jump to Calcium binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
Calcium binding site 1 out
of 8 in 4zma
Go back to
Calcium Binding Sites List in 4zma
Calcium binding site 1 out
of 8 in the Crystal Structure of A Fviia-Trypsin Chimera (St) in Complex with Soluble Tissue Factor
 Mono view
 Stereo pair view
|
|
A full contact list of Calcium with other atoms in the Ca binding
site number 1 of Crystal Structure of A Fviia-Trypsin Chimera (St) in Complex with Soluble Tissue Factor within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
L:Ca201
b:52.7
occ:1.00
|
OD2
|
L:ASP63
|
2.3
|
53.0
|
1.0
|
|
OD1
|
L:ASP63
|
2.3
|
48.1
|
1.0
|
|
OD2
|
L:ASP46
|
2.4
|
55.3
|
1.0
|
|
O
|
L:GLN64
|
2.4
|
46.5
|
1.0
|
|
OE1
|
L:GLN49
|
2.4
|
55.4
|
1.0
|
|
CG
|
L:ASP63
|
2.5
|
48.2
|
1.0
|
|
O
|
L:GLY47
|
2.6
|
46.6
|
1.0
|
|
HE22
|
L:GLN49
|
3.2
|
60.7
|
1.0
|
|
CD
|
L:GLN49
|
3.3
|
53.4
|
1.0
|
|
H
|
L:GLN64
|
3.4
|
48.7
|
1.0
|
|
C
|
L:GLN64
|
3.5
|
44.0
|
1.0
|
|
HA
|
L:ASP48
|
3.5
|
64.0
|
1.0
|
|
H
|
L:GLN49
|
3.5
|
67.5
|
1.0
|
|
CG
|
L:ASP46
|
3.6
|
57.8
|
1.0
|
|
NE2
|
L:GLN49
|
3.6
|
50.6
|
1.0
|
|
H
|
L:GLN66
|
3.7
|
65.0
|
1.0
|
|
C
|
L:GLY47
|
3.8
|
56.8
|
1.0
|
|
N
|
L:GLN64
|
3.8
|
40.6
|
1.0
|
|
HA
|
L:LEU65
|
4.0
|
61.9
|
1.0
|
|
CB
|
L:ASP63
|
4.0
|
52.8
|
1.0
|
|
O
|
L:ASP46
|
4.2
|
58.5
|
1.0
|
|
CA
|
L:GLN64
|
4.2
|
43.3
|
1.0
|
|
OD1
|
L:ASP46
|
4.3
|
57.8
|
1.0
|
|
N
|
L:GLN49
|
4.3
|
56.2
|
1.0
|
|
H
|
L:SER67
|
4.3
|
56.0
|
1.0
|
|
CA
|
L:ASP48
|
4.3
|
53.3
|
1.0
|
|
N
|
L:GLN66
|
4.4
|
54.2
|
1.0
|
|
HB3
|
L:ASP63
|
4.4
|
63.3
|
1.0
|
|
N
|
L:LEU65
|
4.4
|
47.0
|
1.0
|
|
HE21
|
L:GLN49
|
4.4
|
60.7
|
1.0
|
|
C
|
L:ASP63
|
4.5
|
43.4
|
1.0
|
|
O
|
L:SER67
|
4.5
|
49.3
|
1.0
|
|
C
|
L:ASP46
|
4.5
|
58.6
|
1.0
|
|
N
|
L:ASP48
|
4.5
|
63.8
|
1.0
|
|
HB2
|
L:ASP63
|
4.5
|
63.3
|
1.0
|
|
HB2
|
L:GLN49
|
4.6
|
58.6
|
1.0
|
|
HA
|
L:ASP63
|
4.6
|
56.8
|
1.0
|
|
CA
|
L:LEU65
|
4.6
|
51.6
|
1.0
|
|
HB3
|
L:ASP46
|
4.6
|
65.2
|
1.0
|
|
HA
|
L:GLN64
|
4.6
|
51.9
|
1.0
|
|
CA
|
L:ASP63
|
4.6
|
47.4
|
1.0
|
|
CG
|
L:GLN49
|
4.7
|
51.4
|
1.0
|
|
CB
|
L:ASP46
|
4.7
|
54.4
|
1.0
|
|
N
|
L:GLY47
|
4.8
|
57.5
|
1.0
|
|
CA
|
L:GLY47
|
4.9
|
57.0
|
1.0
|
|
C
|
L:ASP48
|
4.9
|
59.8
|
1.0
|
|
OE1
|
T:GLN110
|
4.9
|
45.8
|
1.0
|
|
C
|
L:LEU65
|
4.9
|
53.6
|
1.0
|
|
HG2
|
L:GLN49
|
5.0
|
61.7
|
1.0
|
|
Calcium binding site 2 out
of 8 in 4zma
Go back to
Calcium Binding Sites List in 4zma
Calcium binding site 2 out
of 8 in the Crystal Structure of A Fviia-Trypsin Chimera (St) in Complex with Soluble Tissue Factor
 Mono view
 Stereo pair view
|
|
A full contact list of Calcium with other atoms in the Ca binding
site number 2 of Crystal Structure of A Fviia-Trypsin Chimera (St) in Complex with Soluble Tissue Factor within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
L:Ca202
b:44.0
occ:1.00
|
OE11
|
L:CGU29
|
2.1
|
41.4
|
1.0
|
|
OE21
|
L:CGU7
|
2.2
|
45.9
|
1.0
|
|
OE12
|
L:CGU29
|
2.3
|
48.1
|
1.0
|
|
OE12
|
L:CGU7
|
2.3
|
55.8
|
1.0
|
|
O
|
L:HOH315
|
2.4
|
41.1
|
1.0
|
|
O
|
L:HOH301
|
2.4
|
49.8
|
1.0
|
|
OE22
|
L:CGU26
|
2.4
|
48.1
|
1.0
|
|
CD1
|
L:CGU29
|
2.5
|
40.8
|
1.0
|
|
CD2
|
L:CGU7
|
2.5
|
50.8
|
1.0
|
|
OE22
|
L:CGU7
|
3.0
|
62.8
|
1.0
|
|
CD1
|
L:CGU7
|
3.2
|
54.5
|
1.0
|
|
CD2
|
L:CGU26
|
3.3
|
54.1
|
1.0
|
|
CA
|
L:CA203
|
3.4
|
47.4
|
1.0
|
|
CG
|
L:CGU7
|
3.4
|
54.9
|
1.0
|
|
OE21
|
L:CGU26
|
3.5
|
55.1
|
1.0
|
|
HD21
|
L:ASN2
|
3.9
|
69.7
|
1.0
|
|
HB2
|
L:CGU7
|
4.0
|
62.1
|
1.0
|
|
CG
|
L:CGU29
|
4.1
|
42.6
|
1.0
|
|
OD1
|
L:ASN2
|
4.1
|
63.1
|
1.0
|
|
HA
|
L:CGU26
|
4.1
|
59.0
|
1.0
|
|
O
|
L:HOH307
|
4.2
|
44.9
|
1.0
|
|
HG
|
L:CGU7
|
4.3
|
65.9
|
1.0
|
|
CB
|
L:CGU7
|
4.3
|
51.8
|
1.0
|
|
OE11
|
L:CGU7
|
4.4
|
49.8
|
1.0
|
|
ND2
|
L:ASN2
|
4.5
|
58.1
|
1.0
|
|
HG
|
L:CGU29
|
4.5
|
51.2
|
1.0
|
|
CG
|
L:ASN2
|
4.6
|
57.5
|
1.0
|
|
HB3
|
L:CGU29
|
4.7
|
63.4
|
1.0
|
|
CD2
|
L:CGU29
|
4.7
|
45.9
|
1.0
|
|
CG
|
L:CGU26
|
4.8
|
53.4
|
1.0
|
|
OE21
|
L:CGU29
|
4.9
|
46.4
|
1.0
|
|
CB
|
L:CGU29
|
4.9
|
52.8
|
1.0
|
|
HG
|
L:CGU26
|
4.9
|
64.0
|
1.0
|
|
O
|
L:HOH303
|
5.0
|
48.0
|
1.0
|
|
HB3
|
L:CGU7
|
5.0
|
62.1
|
1.0
|
|
Calcium binding site 3 out
of 8 in 4zma
Go back to
Calcium Binding Sites List in 4zma
Calcium binding site 3 out
of 8 in the Crystal Structure of A Fviia-Trypsin Chimera (St) in Complex with Soluble Tissue Factor
 Mono view
 Stereo pair view
|
|
A full contact list of Calcium with other atoms in the Ca binding
site number 3 of Crystal Structure of A Fviia-Trypsin Chimera (St) in Complex with Soluble Tissue Factor within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
L:Ca203
b:47.4
occ:1.00
|
OE22
|
L:CGU7
|
2.1
|
62.8
|
1.0
|
|
OE21
|
L:CGU7
|
2.3
|
45.9
|
1.0
|
|
O
|
L:HOH307
|
2.4
|
44.9
|
1.0
|
|
O
|
L:HOH303
|
2.4
|
48.0
|
1.0
|
|
OE12
|
L:CGU29
|
2.5
|
48.1
|
1.0
|
|
OE21
|
L:CGU26
|
2.5
|
55.1
|
1.0
|
|
OE11
|
L:CGU16
|
2.5
|
59.1
|
1.0
|
|
CD2
|
L:CGU7
|
2.5
|
50.8
|
1.0
|
|
OE12
|
L:CGU16
|
3.2
|
52.2
|
1.0
|
|
CD1
|
L:CGU16
|
3.2
|
57.6
|
1.0
|
|
CD2
|
L:CGU26
|
3.3
|
54.1
|
1.0
|
|
CA
|
L:CA202
|
3.4
|
44.0
|
1.0
|
|
OE22
|
L:CGU26
|
3.7
|
48.1
|
1.0
|
|
CD1
|
L:CGU29
|
3.7
|
40.8
|
1.0
|
|
OE21
|
L:CGU6
|
3.8
|
54.2
|
1.0
|
|
CA
|
L:CA204
|
3.8
|
64.8
|
1.0
|
|
HA
|
L:CGU26
|
3.9
|
59.0
|
1.0
|
|
HA
|
L:CGU7
|
3.9
|
54.3
|
1.0
|
|
HB3
|
L:CGU29
|
4.0
|
63.4
|
1.0
|
|
CG
|
L:CGU7
|
4.0
|
54.9
|
1.0
|
|
OD1
|
L:ASN2
|
4.1
|
63.1
|
1.0
|
|
HB2
|
L:CGU26
|
4.1
|
60.8
|
1.0
|
|
HB2
|
L:CGU29
|
4.1
|
63.4
|
1.0
|
|
HA2
|
L:GLY11
|
4.3
|
64.4
|
1.0
|
|
HG
|
L:CGU7
|
4.4
|
65.9
|
1.0
|
|
HA3
|
L:GLY11
|
4.4
|
64.4
|
1.0
|
|
OE11
|
L:CGU29
|
4.5
|
41.4
|
1.0
|
|
CB
|
L:CGU29
|
4.5
|
52.8
|
1.0
|
|
CG
|
L:CGU26
|
4.5
|
53.4
|
1.0
|
|
CB
|
L:CGU26
|
4.6
|
50.6
|
1.0
|
|
CG
|
L:CGU16
|
4.7
|
58.2
|
1.0
|
|
CG
|
L:CGU29
|
4.7
|
42.6
|
1.0
|
|
CA
|
L:CGU26
|
4.7
|
49.1
|
1.0
|
|
HB2
|
L:CGU7
|
4.7
|
62.1
|
1.0
|
|
CB
|
L:CGU7
|
4.8
|
51.8
|
1.0
|
|
OE11
|
L:CGU26
|
4.8
|
56.0
|
1.0
|
|
CA
|
L:GLY11
|
4.8
|
53.7
|
1.0
|
|
O
|
L:CGU26
|
4.8
|
56.1
|
1.0
|
|
CA
|
L:CGU7
|
4.8
|
45.2
|
1.0
|
|
OE12
|
L:CGU7
|
4.8
|
55.8
|
1.0
|
|
CD2
|
L:CGU6
|
4.9
|
59.0
|
1.0
|
|
CD1
|
L:CGU7
|
5.0
|
54.5
|
1.0
|
|
Calcium binding site 4 out
of 8 in 4zma
Go back to
Calcium Binding Sites List in 4zma
Calcium binding site 4 out
of 8 in the Crystal Structure of A Fviia-Trypsin Chimera (St) in Complex with Soluble Tissue Factor
 Mono view
 Stereo pair view
|
|
A full contact list of Calcium with other atoms in the Ca binding
site number 4 of Crystal Structure of A Fviia-Trypsin Chimera (St) in Complex with Soluble Tissue Factor within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
L:Ca204
b:64.8
occ:1.00
|
O
|
L:ALA1
|
1.9
|
71.7
|
1.0
|
|
OE22
|
L:CGU6
|
2.1
|
70.9
|
1.0
|
|
OE21
|
L:CGU6
|
2.3
|
54.2
|
1.0
|
|
OE11
|
L:CGU16
|
2.4
|
59.1
|
1.0
|
|
OD1
|
L:ASN2
|
2.4
|
63.1
|
1.0
|
|
OE22
|
L:CGU16
|
2.5
|
57.2
|
1.0
|
|
OE21
|
L:CGU26
|
2.5
|
55.1
|
1.0
|
|
CD2
|
L:CGU6
|
2.5
|
59.0
|
1.0
|
|
C
|
L:ALA1
|
2.5
|
62.9
|
1.0
|
|
OE11
|
L:CGU26
|
2.6
|
56.0
|
1.0
|
|
OE22
|
L:CGU7
|
2.8
|
62.8
|
1.0
|
|
HA
|
L:ASN2
|
2.9
|
74.7
|
1.0
|
|
H2
|
L:ALA1
|
3.1
|
74.6
|
1.0
|
|
N
|
L:ASN2
|
3.2
|
57.3
|
1.0
|
|
H3
|
L:ALA1
|
3.3
|
74.6
|
1.0
|
|
CD2
|
L:CGU16
|
3.4
|
55.4
|
1.0
|
|
CG
|
L:ASN2
|
3.4
|
57.5
|
1.0
|
|
N
|
L:ALA1
|
3.4
|
62.1
|
1.0
|
|
CA
|
L:ASN2
|
3.5
|
62.2
|
1.0
|
|
CA
|
L:ALA1
|
3.5
|
59.6
|
1.0
|
|
CD1
|
L:CGU16
|
3.5
|
57.6
|
1.0
|
|
CD2
|
L:CGU26
|
3.6
|
54.1
|
1.0
|
|
CD1
|
L:CGU26
|
3.6
|
51.7
|
1.0
|
|
CA
|
L:CA205
|
3.7
|
57.2
|
1.0
|
|
CA
|
L:CA203
|
3.8
|
47.4
|
1.0
|
|
HA
|
L:ALA1
|
3.8
|
71.6
|
1.0
|
|
H
|
L:ASN2
|
3.9
|
68.7
|
1.0
|
|
CD2
|
L:CGU7
|
4.0
|
50.8
|
1.0
|
|
CG
|
L:CGU16
|
4.0
|
58.2
|
1.0
|
|
CB
|
L:ASN2
|
4.0
|
56.5
|
1.0
|
|
HG
|
L:CGU7
|
4.0
|
65.9
|
1.0
|
|
CG
|
L:CGU6
|
4.1
|
55.8
|
1.0
|
|
HB2
|
L:CGU6
|
4.1
|
67.9
|
1.0
|
|
CG
|
L:CGU26
|
4.2
|
53.4
|
1.0
|
|
HB2
|
L:CGU16
|
4.2
|
77.4
|
1.0
|
|
OE21
|
L:CGU16
|
4.3
|
57.6
|
1.0
|
|
H1
|
L:ALA1
|
4.3
|
74.6
|
1.0
|
|
ND2
|
L:ASN2
|
4.4
|
58.1
|
1.0
|
|
HB2
|
L:CGU26
|
4.4
|
60.8
|
1.0
|
|
HD21
|
L:ASN2
|
4.5
|
69.7
|
1.0
|
|
OE22
|
L:CGU26
|
4.5
|
48.1
|
1.0
|
|
HB3
|
L:ASN2
|
4.5
|
67.8
|
1.0
|
|
OE12
|
L:CGU16
|
4.6
|
52.2
|
1.0
|
|
HG
|
L:CGU6
|
4.6
|
67.0
|
1.0
|
|
CG
|
L:CGU7
|
4.6
|
54.9
|
1.0
|
|
H
|
L:ALA3
|
4.6
|
66.2
|
1.0
|
|
OE12
|
L:CGU26
|
4.6
|
48.2
|
1.0
|
|
CB
|
L:CGU6
|
4.7
|
56.6
|
1.0
|
|
CB
|
L:CGU16
|
4.7
|
64.5
|
1.0
|
|
OE12
|
L:CGU20
|
4.7
|
61.4
|
1.0
|
|
HB2
|
L:ASN2
|
4.7
|
67.8
|
1.0
|
|
C
|
L:ASN2
|
4.8
|
61.9
|
1.0
|
|
CB
|
L:ALA1
|
4.8
|
61.6
|
1.0
|
|
HA
|
L:CGU16
|
4.9
|
71.2
|
1.0
|
|
CD1
|
L:CGU6
|
4.9
|
64.2
|
1.0
|
|
HB3
|
L:ALA1
|
4.9
|
73.9
|
1.0
|
|
OE21
|
L:CGU7
|
4.9
|
45.9
|
1.0
|
|
HG
|
L:CGU16
|
4.9
|
69.9
|
1.0
|
|
CB
|
L:CGU26
|
4.9
|
50.6
|
1.0
|
|
OE12
|
L:CGU6
|
4.9
|
66.5
|
1.0
|
|
Calcium binding site 5 out
of 8 in 4zma
Go back to
Calcium Binding Sites List in 4zma
Calcium binding site 5 out
of 8 in the Crystal Structure of A Fviia-Trypsin Chimera (St) in Complex with Soluble Tissue Factor
 Mono view
 Stereo pair view
|
|
A full contact list of Calcium with other atoms in the Ca binding
site number 5 of Crystal Structure of A Fviia-Trypsin Chimera (St) in Complex with Soluble Tissue Factor within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
L:Ca205
b:57.2
occ:1.00
|
OE22
|
L:CGU16
|
2.1
|
57.2
|
1.0
|
|
OE22
|
L:CGU6
|
2.1
|
70.9
|
1.0
|
|
OE12
|
L:CGU6
|
2.3
|
66.5
|
1.0
|
|
OE21
|
L:CGU16
|
2.3
|
57.6
|
1.0
|
|
OE12
|
L:CGU20
|
2.3
|
61.4
|
1.0
|
|
O
|
L:ALA1
|
2.5
|
71.7
|
1.0
|
|
CD1
|
L:CGU6
|
2.5
|
64.2
|
1.0
|
|
CD2
|
L:CGU6
|
2.5
|
59.0
|
1.0
|
|
CD2
|
L:CGU16
|
2.5
|
55.4
|
1.0
|
|
OE11
|
L:CGU20
|
2.8
|
66.4
|
1.0
|
|
H3
|
L:ALA1
|
2.9
|
74.6
|
1.0
|
|
CD1
|
L:CGU20
|
3.0
|
63.8
|
1.0
|
|
CG
|
L:CGU6
|
3.1
|
55.8
|
1.0
|
|
OE11
|
L:CGU6
|
3.2
|
61.2
|
1.0
|
|
OE21
|
L:CGU6
|
3.3
|
54.2
|
1.0
|
|
HE
|
L:ARG15
|
3.4
|
67.8
|
1.0
|
|
C
|
L:ALA1
|
3.5
|
62.9
|
1.0
|
|
HG2
|
L:ARG15
|
3.6
|
71.1
|
1.0
|
|
HA
|
L:CGU16
|
3.6
|
71.2
|
1.0
|
|
CA
|
L:CA204
|
3.7
|
64.8
|
1.0
|
|
N
|
L:ALA1
|
3.7
|
62.1
|
1.0
|
|
HG
|
L:CGU6
|
3.7
|
67.0
|
1.0
|
|
HB3
|
L:ALA1
|
3.8
|
73.9
|
1.0
|
|
CA
|
L:ALA1
|
4.1
|
59.6
|
1.0
|
|
CG
|
L:CGU16
|
4.1
|
58.2
|
1.0
|
|
H2
|
L:ALA1
|
4.1
|
74.6
|
1.0
|
|
NE
|
L:ARG15
|
4.2
|
56.5
|
1.0
|
|
H1
|
L:ALA1
|
4.2
|
74.6
|
1.0
|
|
O
|
L:ARG15
|
4.3
|
61.5
|
1.0
|
|
CB
|
L:CGU6
|
4.3
|
56.6
|
1.0
|
|
H
|
L:ALA3
|
4.3
|
66.2
|
1.0
|
|
HB3
|
L:CGU6
|
4.4
|
67.9
|
1.0
|
|
HA
|
L:ASN2
|
4.4
|
74.7
|
1.0
|
|
CB
|
L:ALA1
|
4.4
|
61.6
|
1.0
|
|
CG
|
L:CGU20
|
4.5
|
65.9
|
1.0
|
|
HD2
|
L:ARG15
|
4.5
|
64.0
|
1.0
|
|
CG
|
L:ARG15
|
4.5
|
59.2
|
1.0
|
|
CA
|
L:CA206
|
4.5
|
70.7
|
1.0
|
|
HB2
|
L:CGU6
|
4.5
|
67.9
|
1.0
|
|
OE11
|
L:CGU16
|
4.6
|
59.1
|
1.0
|
|
HG
|
L:CGU16
|
4.6
|
69.9
|
1.0
|
|
N
|
L:ASN2
|
4.6
|
57.3
|
1.0
|
|
CA
|
L:CGU16
|
4.6
|
59.3
|
1.0
|
|
O
|
L:HOH306
|
4.6
|
55.6
|
1.0
|
|
CD
|
L:ARG15
|
4.6
|
53.4
|
1.0
|
|
HH21
|
L:ARG15
|
4.6
|
56.9
|
1.0
|
|
HB3
|
L:CGU20
|
4.7
|
71.7
|
1.0
|
|
C
|
L:ARG15
|
4.8
|
59.5
|
1.0
|
|
HG
|
L:CGU20
|
4.8
|
79.1
|
1.0
|
|
CB
|
L:CGU16
|
4.8
|
64.5
|
1.0
|
|
CD1
|
L:CGU16
|
4.8
|
57.6
|
1.0
|
|
HA
|
L:ALA1
|
5.0
|
71.6
|
1.0
|
|
HB1
|
L:ALA1
|
5.0
|
73.9
|
1.0
|
|
CA
|
L:ASN2
|
5.0
|
62.2
|
1.0
|
|
Calcium binding site 6 out
of 8 in 4zma
Go back to
Calcium Binding Sites List in 4zma
Calcium binding site 6 out
of 8 in the Crystal Structure of A Fviia-Trypsin Chimera (St) in Complex with Soluble Tissue Factor
 Mono view
 Stereo pair view
|
|
A full contact list of Calcium with other atoms in the Ca binding
site number 6 of Crystal Structure of A Fviia-Trypsin Chimera (St) in Complex with Soluble Tissue Factor within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
L:Ca206
b:70.7
occ:1.00
|
HG
|
L:CGU20
|
2.2
|
79.1
|
1.0
|
|
OE11
|
L:CGU20
|
2.2
|
66.4
|
1.0
|
|
OE22
|
L:CGU20
|
2.4
|
71.3
|
1.0
|
|
O
|
L:HOH325
|
2.4
|
58.1
|
1.0
|
|
O
|
L:HOH306
|
2.5
|
55.6
|
1.0
|
|
CG
|
L:CGU20
|
2.5
|
65.9
|
1.0
|
|
CD2
|
L:CGU20
|
2.5
|
67.4
|
1.0
|
|
CD1
|
L:CGU20
|
2.5
|
63.8
|
1.0
|
|
OE21
|
L:CGU20
|
3.5
|
63.3
|
1.0
|
|
O
|
L:ARG15
|
3.5
|
61.5
|
1.0
|
|
HG
|
L:CGU19
|
3.6
|
81.9
|
1.0
|
|
OE12
|
L:CGU20
|
3.6
|
61.4
|
1.0
|
|
HB2
|
L:CGU19
|
3.7
|
79.5
|
1.0
|
|
HG2
|
L:ARG15
|
3.7
|
71.1
|
1.0
|
|
OE21
|
L:CGU19
|
3.7
|
77.9
|
1.0
|
|
HG3
|
L:ARG15
|
4.0
|
71.1
|
1.0
|
|
CB
|
L:CGU20
|
4.0
|
59.7
|
1.0
|
|
CG
|
L:ARG15
|
4.3
|
59.2
|
1.0
|
|
CG
|
L:CGU19
|
4.4
|
68.3
|
1.0
|
|
HB3
|
L:CGU20
|
4.5
|
71.7
|
1.0
|
|
CD2
|
L:CGU19
|
4.5
|
72.0
|
1.0
|
|
CB
|
L:CGU19
|
4.5
|
66.3
|
1.0
|
|
N
|
L:CGU20
|
4.5
|
68.1
|
1.0
|
|
CA
|
L:CA205
|
4.5
|
57.2
|
1.0
|
|
C
|
L:CGU19
|
4.6
|
62.8
|
1.0
|
|
HB2
|
L:CGU20
|
4.6
|
71.7
|
1.0
|
|
C
|
L:ARG15
|
4.7
|
59.5
|
1.0
|
|
O
|
L:CGU19
|
4.7
|
60.5
|
1.0
|
|
HA
|
L:ARG15
|
4.7
|
70.0
|
1.0
|
|
CA
|
L:CGU20
|
4.7
|
68.0
|
1.0
|
|
H
|
L:CGU20
|
4.8
|
81.7
|
1.0
|
|
HA
|
L:CGU20
|
4.9
|
81.6
|
1.0
|
|
HD2
|
L:ARG15
|
5.0
|
64.0
|
1.0
|
|
OE12
|
L:CGU6
|
5.0
|
66.5
|
1.0
|
|
Calcium binding site 7 out
of 8 in 4zma
Go back to
Calcium Binding Sites List in 4zma
Calcium binding site 7 out
of 8 in the Crystal Structure of A Fviia-Trypsin Chimera (St) in Complex with Soluble Tissue Factor
 Mono view
 Stereo pair view
|
|
A full contact list of Calcium with other atoms in the Ca binding
site number 7 of Crystal Structure of A Fviia-Trypsin Chimera (St) in Complex with Soluble Tissue Factor within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
L:Ca207
b:73.9
occ:1.00
|
O
|
L:HOH328
|
2.4
|
63.6
|
1.0
|
|
OE11
|
L:CGU14
|
2.5
|
71.3
|
1.0
|
|
OE11
|
L:CGU19
|
2.5
|
76.0
|
1.0
|
|
OE22
|
L:CGU19
|
2.5
|
67.6
|
1.0
|
|
OE21
|
L:CGU14
|
2.6
|
67.6
|
1.0
|
|
CD1
|
L:CGU14
|
3.3
|
64.8
|
1.0
|
|
CD2
|
L:CGU14
|
3.3
|
60.3
|
1.0
|
|
HB3
|
L:CGU19
|
3.4
|
79.5
|
1.0
|
|
CD2
|
L:CGU19
|
3.5
|
72.0
|
1.0
|
|
CD1
|
L:CGU19
|
3.5
|
71.7
|
1.0
|
|
CG
|
L:CGU19
|
3.9
|
68.3
|
1.0
|
|
CG
|
L:CGU14
|
3.9
|
61.7
|
1.0
|
|
OE22
|
L:CGU14
|
4.1
|
61.6
|
1.0
|
|
OE12
|
L:CGU14
|
4.1
|
59.0
|
1.0
|
|
CB
|
L:CGU19
|
4.2
|
66.3
|
1.0
|
|
OE21
|
L:CGU19
|
4.6
|
77.9
|
1.0
|
|
OE12
|
L:CGU19
|
4.7
|
69.5
|
1.0
|
|
HB2
|
L:CGU14
|
4.7
|
72.7
|
1.0
|
|
HG
|
L:CGU14
|
4.7
|
74.0
|
1.0
|
|
HA
|
L:CGU19
|
4.8
|
72.8
|
1.0
|
|
CB
|
L:CGU14
|
4.9
|
60.5
|
1.0
|
|
O
|
L:CGU14
|
4.9
|
60.8
|
1.0
|
|
HB2
|
L:CGU19
|
4.9
|
79.5
|
1.0
|
|
Calcium binding site 8 out
of 8 in 4zma
Go back to
Calcium Binding Sites List in 4zma
Calcium binding site 8 out
of 8 in the Crystal Structure of A Fviia-Trypsin Chimera (St) in Complex with Soluble Tissue Factor
 Mono view
 Stereo pair view
|
|
A full contact list of Calcium with other atoms in the Ca binding
site number 8 of Crystal Structure of A Fviia-Trypsin Chimera (St) in Complex with Soluble Tissue Factor within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
H:Ca502
b:32.7
occ:1.00
|
OE1
|
H:GLU70
|
2.3
|
32.0
|
1.0
|
|
OE1
|
H:GLU80
|
2.3
|
30.7
|
1.0
|
|
O
|
H:ASP72
|
2.3
|
32.6
|
1.0
|
|
O
|
H:GLU75
|
2.4
|
36.4
|
1.0
|
|
OE2
|
H:GLU70
|
2.4
|
36.7
|
1.0
|
|
O
|
H:HOH658
|
2.4
|
25.9
|
1.0
|
|
O
|
H:HOH648
|
2.4
|
34.0
|
1.0
|
|
CD
|
H:GLU70
|
2.7
|
31.9
|
1.0
|
|
HA
|
H:HIS76
|
3.2
|
38.9
|
1.0
|
|
HG2
|
H:GLU80
|
3.3
|
33.5
|
1.0
|
|
CD
|
H:GLU80
|
3.4
|
35.9
|
1.0
|
|
C
|
H:ASP72
|
3.5
|
34.0
|
1.0
|
|
C
|
H:GLU75
|
3.6
|
36.1
|
1.0
|
|
H
|
H:HIS71
|
3.6
|
24.7
|
1.0
|
|
H
|
H:ASP72
|
3.6
|
34.0
|
1.0
|
|
CG
|
H:GLU80
|
3.7
|
28.0
|
1.0
|
|
HG3
|
H:GLU80
|
3.8
|
33.5
|
1.0
|
|
HA
|
H:LEU73
|
3.9
|
36.9
|
1.0
|
|
O
|
H:HOH664
|
3.9
|
25.1
|
1.0
|
|
H
|
H:GLU75
|
4.0
|
40.2
|
1.0
|
|
H
|
H:ASP77
|
4.0
|
36.6
|
1.0
|
|
HA
|
H:GLU70
|
4.1
|
31.0
|
1.0
|
|
N
|
H:ASP72
|
4.1
|
28.3
|
1.0
|
|
CA
|
H:HIS76
|
4.1
|
32.4
|
1.0
|
|
HB3
|
H:ASP72
|
4.1
|
34.1
|
1.0
|
|
CG
|
H:GLU70
|
4.2
|
31.7
|
1.0
|
|
N
|
H:HIS76
|
4.3
|
36.2
|
1.0
|
|
CA
|
H:ASP72
|
4.3
|
26.5
|
1.0
|
|
N
|
H:LEU73
|
4.4
|
31.0
|
1.0
|
|
N
|
H:HIS71
|
4.4
|
20.6
|
1.0
|
|
OE2
|
H:GLU80
|
4.5
|
35.8
|
1.0
|
|
CA
|
H:LEU73
|
4.5
|
30.8
|
1.0
|
|
O
|
H:HOH633
|
4.5
|
35.9
|
1.0
|
|
HG3
|
H:GLU70
|
4.6
|
38.0
|
1.0
|
|
HG2
|
H:GLU70
|
4.6
|
38.0
|
1.0
|
|
N
|
H:GLU75
|
4.7
|
33.5
|
1.0
|
|
CA
|
H:GLU75
|
4.7
|
30.9
|
1.0
|
|
N
|
H:ASP77
|
4.7
|
30.5
|
1.0
|
|
CB
|
H:ASP72
|
4.8
|
28.4
|
1.0
|
|
HD23
|
H:LEU73
|
4.8
|
36.3
|
1.0
|
|
C
|
H:LEU73
|
4.8
|
31.0
|
1.0
|
|
CA
|
H:GLU70
|
4.8
|
25.8
|
1.0
|
|
HD2
|
H:HIS76
|
4.9
|
45.4
|
1.0
|
|
CB
|
H:GLU70
|
4.9
|
28.0
|
1.0
|
|
HB2
|
H:GLU70
|
4.9
|
33.6
|
1.0
|
|
C
|
H:HIS71
|
5.0
|
25.7
|
1.0
|
|
O
|
H:LEU73
|
5.0
|
34.0
|
1.0
|
|
Reference:
A.B.Sorensen,
J.J.Madsen,
L.A.Svensson,
A.A.Pedersen,
H.Stergaard,
M.T.Overgaard,
O.H.Olsen,
P.S.Gandhi.
Molecular Basis of Enhanced Activity in Factor Viia-Trypsin Variants Conveys Insights Into Tissue Factor-Mediated Allosteric Regulation of Factor Viia Activity. J.Biol.Chem. V. 291 4671 2016.
ISSN: ESSN 1083-351X
PubMed: 26694616
DOI: 10.1074/JBC.M115.698613
Page generated: Sun Jul 14 15:48:29 2024
|
