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Atomistry » Calcium » PDB 4zmp-5a3o » 4zxx » |
Calcium in PDB 4zxx: Factor Viia in Complex with the Inhibitor N-{3-[(2R)-1-{(2R)-2-[(1- Aminoisoquinolin-6-Yl)Amino]-2-Phenylacetyl}Pyrrolidin-2-Yl]-4- (Propan-2-Ylsulfonyl)Phenyl}AcetamideEnzymatic activity of Factor Viia in Complex with the Inhibitor N-{3-[(2R)-1-{(2R)-2-[(1- Aminoisoquinolin-6-Yl)Amino]-2-Phenylacetyl}Pyrrolidin-2-Yl]-4- (Propan-2-Ylsulfonyl)Phenyl}Acetamide
All present enzymatic activity of Factor Viia in Complex with the Inhibitor N-{3-[(2R)-1-{(2R)-2-[(1- Aminoisoquinolin-6-Yl)Amino]-2-Phenylacetyl}Pyrrolidin-2-Yl]-4- (Propan-2-Ylsulfonyl)Phenyl}Acetamide:
3.4.21.21; Protein crystallography data
The structure of Factor Viia in Complex with the Inhibitor N-{3-[(2R)-1-{(2R)-2-[(1- Aminoisoquinolin-6-Yl)Amino]-2-Phenylacetyl}Pyrrolidin-2-Yl]-4- (Propan-2-Ylsulfonyl)Phenyl}Acetamide, PDB code: 4zxx
was solved by
A.Wei,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Calcium Binding Sites:
The binding sites of Calcium atom in the Factor Viia in Complex with the Inhibitor N-{3-[(2R)-1-{(2R)-2-[(1- Aminoisoquinolin-6-Yl)Amino]-2-Phenylacetyl}Pyrrolidin-2-Yl]-4- (Propan-2-Ylsulfonyl)Phenyl}Acetamide
(pdb code 4zxx). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Factor Viia in Complex with the Inhibitor N-{3-[(2R)-1-{(2R)-2-[(1- Aminoisoquinolin-6-Yl)Amino]-2-Phenylacetyl}Pyrrolidin-2-Yl]-4- (Propan-2-Ylsulfonyl)Phenyl}Acetamide, PDB code: 4zxx: Calcium binding site 1 out of 1 in 4zxxGo back to Calcium Binding Sites List in 4zxx
Calcium binding site 1 out
of 1 in the Factor Viia in Complex with the Inhibitor N-{3-[(2R)-1-{(2R)-2-[(1- Aminoisoquinolin-6-Yl)Amino]-2-Phenylacetyl}Pyrrolidin-2-Yl]-4- (Propan-2-Ylsulfonyl)Phenyl}Acetamide
Mono view Stereo pair view
Reference:
E.S.Priestley,
D.L.Cheney,
I.Delucca,
A.Wei,
J.M.Luettgen,
A.R.Rendina,
P.C.Wong,
R.R.Wexler.
Structure-Based Design of Macrocyclic Coagulation Factor Viia Inhibitors. J.Med.Chem. V. 58 6225 2015.
Page generated: Sun Jul 14 16:11:51 2024
ISSN: ISSN 0022-2623 PubMed: 26151189 DOI: 10.1021/ACS.JMEDCHEM.5B00788 |
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