Calcium in PDB 5ful: Crystal Structure of Mus Musculus Protein Arginine Methyltransferase 2 with Sah

All present enzymatic activity of Crystal Structure of Mus Musculus Protein Arginine Methyltransferase 2 with Sah:
2.1.1.125;

The structure of Crystal Structure of Mus Musculus Protein Arginine Methyltransferase 2 with Sah, PDB code: 5ful was solved by V.Cura, N.Troffer-Charlier, N.Marechal, L.Bonnefond, J.Cavarelli, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.26 / 1.89
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	65.507, 115.414, 132.963, 90.00, 90.00, 90.00
R / Rfree (%)	16.6 / 19.2

The structure of Crystal Structure of Mus Musculus Protein Arginine Methyltransferase 2 with Sah also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Calcium atom in the Crystal Structure of Mus Musculus Protein Arginine Methyltransferase 2 with Sah (pdb code 5ful). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Crystal Structure of Mus Musculus Protein Arginine Methyltransferase 2 with Sah, PDB code: 5ful:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Crystal Structure of Mus Musculus Protein Arginine Methyltransferase 2 with Sah


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of Mus Musculus Protein Arginine Methyltransferase 2 with Sah within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1447 b:80.1 occ:1.00 O A:HOH2090 2.3 51.7 1.0 O A:HOH2085 2.4 58.0 1.0 O A:GLY196 2.5 40.8 1.0 OD1 A:ASP199 2.6 53.1 1.0 OD2 A:ASP199 2.7 55.5 1.0 CG A:ASP199 3.0 51.9 1.0 C A:GLY196 3.7 39.8 1.0 CA A:PHE197 4.1 37.6 1.0 CD1 A:PHE197 4.3 39.6 1.0 N A:PHE197 4.4 37.6 1.0 CB A:ASP199 4.6 48.8 1.0 OG1 A:THR200 4.6 41.2 1.0 O A:HOH2084 4.7 49.0 1.0 CA A:GLY196 4.8 40.4 1.0 C A:PHE197 4.9 36.4 1.0

Calcium binding site 2 out of 2 in the Crystal Structure of Mus Musculus Protein Arginine Methyltransferase 2 with Sah


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Crystal Structure of Mus Musculus Protein Arginine Methyltransferase 2 with Sah within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1448 b:34.3 occ:1.00 O A:HOH2023 2.3 29.1 1.0 O A:HOH2126 2.3 30.4 1.0 O A:HOH2128 2.4 44.8 1.0 O A:MET225 2.4 25.5 1.0 O A:HOH2132 2.5 38.7 1.0 O A:HOH2016 2.5 34.5 1.0 O A:HOH2015 2.5 39.9 1.0 C A:MET225 3.6 24.7 1.0 NE1 A:TRP382 4.1 28.0 1.0 OH A:TYR118 4.3 30.8 1.0 CA A:GLY226 4.3 24.4 1.0 OE1 A:GLU223 4.3 29.0 1.0 N A:GLY226 4.3 25.1 1.0 N A:MET225 4.4 23.2 1.0 OE2 A:GLU223 4.4 28.9 1.0 O A:HOH2037 4.5 54.3 1.0 O A:TRP224 4.5 26.9 1.0 C A:TRP224 4.5 24.8 1.0 NE2 A:HIS381 4.5 25.4 1.0 CZ2 A:TRP382 4.5 26.1 1.0 OE2 A:GLU232 4.6 36.9 1.0 CA A:MET225 4.6 23.9 1.0 CE2 A:TRP382 4.6 27.3 1.0 OE1 A:GLU232 4.7 34.6 1.0 SD A:SAH1446 4.8 30.2 1.0 CD A:GLU223 4.8 29.0 1.0 O A:HOH2133 4.8 32.7 1.0 SD A:MET127 4.8 33.4 1.0 CD A:GLU232 4.9 34.8 1.0

V.Cura, N.Marechal, N.Troffer-Charlier, J.M.Strub, M.J.Van Haren, N.I.Martin, S.Cianferani, L.Bonnefond, J.Cavarelli. Structural Studies of Protein Arginine Methyltransferase 2 Reveal Its Interactions with Potential Substrates and Inhibitors. Febs J. V. 284 77 2017.
ISSN: ISSN 1742-4658
PubMed: 27879050
DOI: 10.1111/FEBS.13953