Calcium in PDB 5fwa: Crystal Structure of Mus Musculus Protein Arginine Methyltransferase 2 with CP1

All present enzymatic activity of Crystal Structure of Mus Musculus Protein Arginine Methyltransferase 2 with CP1:
2.1.1.125;

The structure of Crystal Structure of Mus Musculus Protein Arginine Methyltransferase 2 with CP1, PDB code: 5fwa was solved by V.Cura, N.Troffer-Charlier, N.Marechal, L.Bonnefond, J.Cavarelli, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.37 / 1.80
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	66.183, 114.676, 132.653, 90.00, 90.00, 90.00
R / Rfree (%)	17.2 / 19.1

The structure of Crystal Structure of Mus Musculus Protein Arginine Methyltransferase 2 with CP1 also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Calcium atom in the Crystal Structure of Mus Musculus Protein Arginine Methyltransferase 2 with CP1 (pdb code 5fwa). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Crystal Structure of Mus Musculus Protein Arginine Methyltransferase 2 with CP1, PDB code: 5fwa:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Crystal Structure of Mus Musculus Protein Arginine Methyltransferase 2 with CP1


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of Mus Musculus Protein Arginine Methyltransferase 2 with CP1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1452 b:91.5 occ:1.00 OD2 A:ASP199 2.4 62.4 1.0 OD1 A:ASP199 2.4 53.9 1.0 O A:HOH2087 2.5 58.9 1.0 O A:HOH2089 2.5 57.6 1.0 O A:GLY196 2.6 39.0 1.0 CG A:ASP199 2.7 56.9 1.0 C A:GLY196 3.8 39.0 1.0 CB A:ASP199 4.2 47.2 1.0 CA A:PHE197 4.3 32.1 1.0 N A:PHE197 4.5 34.2 1.0 CD1 A:PHE197 4.6 34.8 1.0 OG1 A:THR200 4.6 40.7 1.0 N A:ASP199 4.9 32.3 1.0 CA A:GLY196 4.9 38.6 1.0 C A:PHE197 4.9 32.9 1.0

Calcium binding site 2 out of 2 in the Crystal Structure of Mus Musculus Protein Arginine Methyltransferase 2 with CP1


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Crystal Structure of Mus Musculus Protein Arginine Methyltransferase 2 with CP1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1453 b:78.3 occ:0.50 O A:HOH2033 2.2 44.9 1.0 O A:HOH2038 2.8 51.3 1.0 OE2 A:GLU146 4.1 67.3 1.0 OE1 A:GLN143 4.1 57.9 1.0 O A:LEU142 4.2 32.4 1.0 OE1 A:GLU146 4.4 60.7 1.0 CA A:GLN143 4.5 30.0 1.0 O A:GLN143 4.6 36.5 1.0 CD A:GLN143 4.7 55.8 1.0 CD A:GLU146 4.7 63.3 1.0 C A:GLN143 4.9 33.4 1.0 NE2 A:GLN143 4.9 59.3 1.0

V.Cura, N.Marechal, N.Troffer-Charlier, J.M.Strub, M.J.Van Haren, N.I.Martin, S.Cianferani, L.Bonnefond, J.Cavarelli. Structural Studies of Protein Arginine Methyltransferase 2 Reveal Its Interactions with Potential Substrates and Inhibitors. Febs J. V. 284 77 2017.
ISSN: ISSN 1742-4658
PubMed: 27879050
DOI: 10.1111/FEBS.13953