Calcium in PDB 5fwd: Crystal Structure of Mus Musculus Protein Arginine Methyltransferase 2 with CP2

All present enzymatic activity of Crystal Structure of Mus Musculus Protein Arginine Methyltransferase 2 with CP2:
2.1.1.125;

The structure of Crystal Structure of Mus Musculus Protein Arginine Methyltransferase 2 with CP2, PDB code: 5fwd was solved by V.Cura, N.Troffer-Charlier, N.Marechal, L.Bonnefond, J.Cavarelli, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.26 / 2.00
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	65.964, 114.520, 132.085, 90.00, 90.00, 90.00
R / Rfree (%)	18.8 / 20.9

The structure of Crystal Structure of Mus Musculus Protein Arginine Methyltransferase 2 with CP2 also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Calcium atom in the Crystal Structure of Mus Musculus Protein Arginine Methyltransferase 2 with CP2 (pdb code 5fwd). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Crystal Structure of Mus Musculus Protein Arginine Methyltransferase 2 with CP2, PDB code: 5fwd:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Crystal Structure of Mus Musculus Protein Arginine Methyltransferase 2 with CP2


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of Mus Musculus Protein Arginine Methyltransferase 2 with CP2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1455 b:99.5 occ:1.00 O A:HOH2089 2.3 50.6 1.0 OD1 A:ASP199 2.4 51.2 1.0 OD2 A:ASP199 2.4 59.7 1.0 CG A:ASP199 2.7 53.4 1.0 O A:HOH2087 2.7 56.8 1.0 O A:GLY196 2.7 41.0 1.0 C A:GLY196 3.9 38.7 1.0 CB A:ASP199 4.2 47.4 1.0 CA A:PHE197 4.3 32.8 1.0 N A:PHE197 4.5 34.2 1.0 O A:HOH2090 4.6 50.8 1.0 OG1 A:THR200 4.6 43.3 1.0 CD1 A:PHE197 4.7 37.7 1.0 N A:ASP199 4.8 36.1 1.0 C A:PHE197 4.9 30.6 1.0 CA A:GLY196 5.0 40.8 1.0

Calcium binding site 2 out of 2 in the Crystal Structure of Mus Musculus Protein Arginine Methyltransferase 2 with CP2


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Crystal Structure of Mus Musculus Protein Arginine Methyltransferase 2 with CP2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1460 b:53.7 occ:0.50 O A:HOH2037 2.3 44.4 1.0 O A:HOH2040 2.6 40.1 1.0 OE1 A:GLN143 4.1 55.7 1.0 OE2 A:GLU146 4.2 58.9 1.0 O A:LEU142 4.3 27.4 1.0 OE1 A:GLU146 4.4 51.4 1.0 CA A:GLN143 4.6 31.9 1.0 O A:GLN143 4.7 35.3 1.0 CD A:GLU146 4.7 53.9 1.0 CD A:GLN143 4.8 50.9 1.0 C A:GLN143 4.9 33.0 1.0

V.Cura, N.Marechal, N.Troffer-Charlier, J.M.Strub, M.J.Van Haren, N.I.Martin, S.Cianferani, L.Bonnefond, J.Cavarelli. Structural Studies of Protein Arginine Methyltransferase 2 Reveal Its Interactions with Potential Substrates and Inhibitors. Febs J. V. 284 77 2017.
ISSN: ISSN 1742-464X
PubMed: 27879050
DOI: 10.1111/FEBS.13953