Calcium in PDB 5fww: Wnt Modulator Kremen in Complex with DKK1 (CRD2) and LRP6 (PE3PE4)

The structure of Wnt Modulator Kremen in Complex with DKK1 (CRD2) and LRP6 (PE3PE4), PDB code: 5fww was solved by M.Zebisch, V.A.Jackson, E.Y.Jones, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	135.36 / 3.50
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	86.933, 100.080, 270.728, 90.00, 90.00, 90.00
R / Rfree (%)	32.128 / 35.528

The binding sites of Calcium atom in the Wnt Modulator Kremen in Complex with DKK1 (CRD2) and LRP6 (PE3PE4) (pdb code 5fww). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Wnt Modulator Kremen in Complex with DKK1 (CRD2) and LRP6 (PE3PE4), PDB code: 5fww:

Calcium binding site 1 out of 1 in the Wnt Modulator Kremen in Complex with DKK1 (CRD2) and LRP6 (PE3PE4)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Wnt Modulator Kremen in Complex with DKK1 (CRD2) and LRP6 (PE3PE4) within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1323 b:88.8 occ:1.00 OD1 B:ASP306 2.5 84.0 1.0 O B:ASN309 2.6 86.9 1.0 OG B:SER305 2.9 73.3 1.0 O B:ASP306 3.0 84.0 1.0 OD1 B:ASP266 3.1 71.5 1.0 N B:ASP306 3.5 78.9 1.0 OD2 B:ASP266 3.5 70.9 1.0 C B:ASP306 3.6 85.6 1.0 C B:ASN309 3.6 87.5 1.0 CG B:ASP306 3.7 84.4 1.0 CG B:ASP266 3.7 70.7 1.0 CE1 B:TYR234 3.9 65.4 1.0 CA B:ASP306 3.9 82.9 1.0 N B:ASN309 4.0 94.9 1.0 CG2 B:THR236 4.0 76.0 1.0 C B:SER305 4.1 76.3 1.0 CB B:SER305 4.1 71.9 1.0 OD2 B:ASP263 4.3 78.9 1.0 N B:ILE308 4.3 97.5 1.0 CA B:SER305 4.3 72.8 1.0 CB B:ASP306 4.4 84.3 1.0 CA B:ASN309 4.4 92.3 1.0 N B:GLN310 4.4 83.7 1.0 N B:ARG307 4.5 90.4 1.0 CA B:THR236 4.5 73.7 1.0 CD1 B:TYR234 4.6 64.2 1.0 CA B:GLN310 4.6 78.2 1.0 OD2 B:ASP306 4.6 85.0 1.0 CB B:THR236 4.7 76.5 1.0 OH B:TYR234 4.8 66.4 1.0 C B:ILE308 4.8 98.2 1.0 CG B:GLN310 4.8 79.6 1.0 CZ B:TYR234 4.8 64.8 1.0 O B:SER305 4.9 77.2 1.0 CA B:ARG307 4.9 94.2 1.0

M.Zebisch, V.A.Jackson, Y.Zhao, E.Y.Jones. Structure of the Dual-Mode Wnt Regulator KREMEN1 and Insight Into Ternary Complex Formation with LRP6 and Dickkopf Structure V. 24 1599 2016.
ISSN: ISSN 0969-2126
PubMed: 27524201
DOI: 10.1016/J.STR.2016.06.020