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Calcium in PDB 5jan: Exploitation of A Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-Pla2) Discovered Through X-Ray Fragment Screening
Enzymatic activity of Exploitation of A Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-Pla2) Discovered Through X-Ray Fragment Screening
All present enzymatic activity of Exploitation of A Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-Pla2) Discovered Through X-Ray Fragment Screening:
3.1.1.47;
3.1.1.47;
Protein crystallography data
The structure of Exploitation of A Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-Pla2) Discovered Through X-Ray Fragment Screening, PDB code: 5jan
was solved by
P.J.Day,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 46.33 / 2.12 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 100.373, 92.080, 48.273, 90.00, 112.60, 90.00 |
| R / Rfree (%) | 22.3 / 26.7 |
Other elements in 5jan:
The structure of Exploitation of A Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-Pla2) Discovered Through X-Ray Fragment Screening also contains other interesting chemical elements:
| Chlorine | (Cl) | 2 atoms |
Calcium Binding Sites:
The binding sites of Calcium atom in the Exploitation of A Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-Pla2) Discovered Through X-Ray Fragment Screening
(pdb code 5jan). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Exploitation of A Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-Pla2) Discovered Through X-Ray Fragment Screening, PDB code: 5jan:
In total only one binding site of Calcium was determined in the Exploitation of A Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-Pla2) Discovered Through X-Ray Fragment Screening, PDB code: 5jan:
Calcium binding site 1 out of 1 in 5jan
Go back to
Calcium Binding Sites List in 5jan
Calcium binding site 1 out
of 1 in the Exploitation of A Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-Pla2) Discovered Through X-Ray Fragment Screening
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Calcium with other atoms in the Ca binding
site number 1 of Exploitation of A Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-Pla2) Discovered Through X-Ray Fragment Screening within 5.0Å range:
|
Reference:
A.J.Woolford,
J.E.Pero,
S.Aravapalli,
V.Berdini,
J.E.Coyle,
P.J.Day,
A.M.Dodson,
P.Grondin,
F.P.Holding,
L.Y.Lee,
P.Li,
E.S.Manas,
J.Marino,
A.C.Martin,
B.W.Mccleland,
R.L.Mcmenamin,
C.W.Murray,
C.E.Neipp,
L.W.Page,
V.K.Patel,
F.Potvain,
S.Rich,
R.A.Rivero,
K.Smith,
D.O.Somers,
L.Trottet,
R.Velagaleti,
G.Williams,
R.Xie.
Exploitation of A Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered Through X-Ray Fragment Screening. J.Med.Chem. V. 59 5356 2016.
ISSN: ISSN 0022-2623
PubMed: 27167608
DOI: 10.1021/ACS.JMEDCHEM.6B00212
Page generated: Sun Jul 14 20:56:58 2024
ISSN: ISSN 0022-2623
PubMed: 27167608
DOI: 10.1021/ACS.JMEDCHEM.6B00212
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