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Calcium in PDB 5jj4: Crystal Structure of A Variant Human Activation-Induced Deoxycytidine Deaminase As An Mbp Fusion Protein

Enzymatic activity of Crystal Structure of A Variant Human Activation-Induced Deoxycytidine Deaminase As An Mbp Fusion Protein

All present enzymatic activity of Crystal Structure of A Variant Human Activation-Induced Deoxycytidine Deaminase As An Mbp Fusion Protein:
3.5.4.38;

Protein crystallography data

The structure of Crystal Structure of A Variant Human Activation-Induced Deoxycytidine Deaminase As An Mbp Fusion Protein, PDB code: 5jj4 was solved by L.C.Pedersen, M.F.Goodman, P.Pham, S.A.Afif, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 35.48 / 2.81
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 106.793, 96.806, 108.692, 90.00, 102.86, 90.00
R / Rfree (%) 18.3 / 23.2

Other elements in 5jj4:

The structure of Crystal Structure of A Variant Human Activation-Induced Deoxycytidine Deaminase As An Mbp Fusion Protein also contains other interesting chemical elements:

Zinc (Zn) 3 atoms

Calcium Binding Sites:

The binding sites of Calcium atom in the Crystal Structure of A Variant Human Activation-Induced Deoxycytidine Deaminase As An Mbp Fusion Protein (pdb code 5jj4). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 3 binding sites of Calcium where determined in the Crystal Structure of A Variant Human Activation-Induced Deoxycytidine Deaminase As An Mbp Fusion Protein, PDB code: 5jj4:
Jump to Calcium binding site number: 1; 2; 3;

Calcium binding site 1 out of 3 in 5jj4

Go back to Calcium Binding Sites List in 5jj4
Calcium binding site 1 out of 3 in the Crystal Structure of A Variant Human Activation-Induced Deoxycytidine Deaminase As An Mbp Fusion Protein


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of A Variant Human Activation-Induced Deoxycytidine Deaminase As An Mbp Fusion Protein within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Ca1202

b:0.7
occ:1.00
O C:GLN325 2.5 80.1 1.0
O C:GLY327 2.8 64.8 1.0
C C:GLN325 3.7 77.0 1.0
C C:GLY327 4.0 61.7 1.0
O C:LYS326 4.1 66.8 1.0
C C:LYS326 4.2 70.7 1.0
CA C:GLN325 4.6 75.8 1.0
N C:GLY327 4.6 67.8 1.0
N C:LYS326 4.6 75.3 1.0
CA C:LYS326 4.7 76.5 1.0
O C:ALA324 4.9 62.4 1.0
CA C:GLY327 4.9 64.3 1.0
N C:GLU328 4.9 61.0 1.0
CA C:GLU328 4.9 63.4 1.0

Calcium binding site 2 out of 3 in 5jj4

Go back to Calcium Binding Sites List in 5jj4
Calcium binding site 2 out of 3 in the Crystal Structure of A Variant Human Activation-Induced Deoxycytidine Deaminase As An Mbp Fusion Protein


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Crystal Structure of A Variant Human Activation-Induced Deoxycytidine Deaminase As An Mbp Fusion Protein within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca1202

b:0.9
occ:1.00
O A:GLN325 2.7 94.5 1.0
O A:GLY327 2.8 85.7 1.0
C A:GLN325 3.8 92.7 1.0
C A:GLY327 4.0 82.6 1.0
O A:LYS326 4.1 89.9 1.0
C A:LYS326 4.3 87.7 1.0
CA A:GLN325 4.5 92.8 1.0
N A:LYS326 4.7 90.6 1.0
O A:ALA324 4.7 77.9 1.0
N A:GLY327 4.7 83.8 1.0
CA A:LYS326 4.8 88.4 1.0
CA A:GLU328 4.8 83.9 1.0
N A:GLU328 4.9 82.7 1.0
CA A:GLY327 5.0 80.5 1.0
OE1 A:GLN325 5.0 0.1 1.0

Calcium binding site 3 out of 3 in 5jj4

Go back to Calcium Binding Sites List in 5jj4
Calcium binding site 3 out of 3 in the Crystal Structure of A Variant Human Activation-Induced Deoxycytidine Deaminase As An Mbp Fusion Protein


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Crystal Structure of A Variant Human Activation-Induced Deoxycytidine Deaminase As An Mbp Fusion Protein within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ca1202

b:0.9
occ:1.00
O B:GLY327 2.2 0.3 1.0
O B:GLN325 2.6 97.4 1.0
C B:GLY327 3.4 0.2 1.0
C B:GLN325 3.7 98.3 1.0
O B:HOH1308 3.9 64.3 1.0
O B:ALA324 4.1 93.0 1.0
N B:GLU328 4.1 96.5 1.0
CA B:GLU328 4.2 90.7 1.0
N B:GLY327 4.2 0.2 1.0
CA B:GLN325 4.3 97.6 1.0
CA B:GLY327 4.4 99.4 1.0
C B:LYS326 4.5 0.9 1.0
N B:LYS326 4.7 99.9 1.0
O B:LYS326 4.9 0.9 1.0
CB B:GLU328 5.0 86.2 1.0
CA B:LYS326 5.0 0.6 1.0

Reference:

P.Pham, S.A.Afif, M.Shimoda, K.Maeda, N.Sakaguchi, L.C.Pedersen, M.F.Goodman. Structural Analysis of the Activation-Induced Deoxycytidine Deaminase Required in Immunoglobulin Diversification. Dna Repair (Amst.) V. 43 48 2016.
ISSN: ISSN 1568-7856
PubMed: 27258794
DOI: 10.1016/J.DNAREP.2016.05.029
Page generated: Mon Jul 15 06:28:06 2024

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