Calcium in PDB 5klb: Crystal Structure of the Cavab Voltage-Gated Calcium Channel(Wild- Type, 2.7A)

The structure of Crystal Structure of the Cavab Voltage-Gated Calcium Channel(Wild- Type, 2.7A), PDB code: 5klb was solved by L.Tang, T.M.Gamal El-Din, T.M.Swanson, D.C.Pryde, T.Scheuer, N.Zheng, W.A.Catterall, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.93 / 2.70
Space group	P 21 2 21
Cell size a, b, c (Å), α, β, γ (°)	124.900, 125.700, 191.485, 90.00, 90.00, 90.00
R / Rfree (%)	21.9 / 26

The binding sites of Calcium atom in the Crystal Structure of the Cavab Voltage-Gated Calcium Channel(Wild- Type, 2.7A) (pdb code 5klb). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 3 binding sites of Calcium where determined in the Crystal Structure of the Cavab Voltage-Gated Calcium Channel(Wild- Type, 2.7A), PDB code: 5klb:
Jump to Calcium binding site number: 1; 2; 3;

Calcium binding site 1 out of 3 in the Crystal Structure of the Cavab Voltage-Gated Calcium Channel(Wild- Type, 2.7A)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of the Cavab Voltage-Gated Calcium Channel(Wild- Type, 2.7A) within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1302 b:79.1 occ:1.00 CB A:ASP1178 3.9 38.7 1.0 O A:HOH1401 3.9 44.2 1.0 O B:HOH1401 4.0 43.0 1.0 O C:HOH1401 4.0 44.8 1.0 O D:HOH1401 4.1 42.5 1.0 CG A:ASP1178 4.1 48.9 1.0 OD1 C:ASP1178 4.1 55.4 1.0 CB C:ASP1178 4.2 41.3 1.0 CB D:ASP1178 4.2 35.4 1.0 OD1 A:ASP1178 4.2 52.3 1.0 CB B:ASP1178 4.2 35.1 1.0 CG C:ASP1178 4.2 49.7 1.0 CG B:ASP1178 4.3 47.9 1.0 OD1 B:ASP1178 4.3 51.7 1.0 CA A:ASP1178 4.4 41.6 1.0 CG D:ASP1178 4.4 51.2 1.0 CA C:ASP1178 4.6 40.2 1.0 CA B:ASP1178 4.7 42.9 1.0 OD2 D:ASP1178 4.7 59.1 1.0 CA D:ASP1178 4.7 38.0 1.0 OD2 A:ASP1178 4.7 50.3 1.0 N A:ASP1178 4.7 39.2 1.0 N D:ASP1178 4.9 35.0 1.0 OD2 C:ASP1178 4.9 50.2 1.0 N C:ASP1178 4.9 40.1 1.0 OD2 B:ASP1178 5.0 45.0 1.0 OD1 D:ASP1178 5.0 49.8 1.0

Calcium binding site 2 out of 3 in the Crystal Structure of the Cavab Voltage-Gated Calcium Channel(Wild- Type, 2.7A)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Crystal Structure of the Cavab Voltage-Gated Calcium Channel(Wild- Type, 2.7A) within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1301 b:0.9 occ:1.00 OD1 D:ASN1225 2.9 75.3 1.0 OD1 B:ASN1225 3.0 77.7 1.0 OE1 D:GLU1228 3.1 85.8 1.0 OE1 C:GLU1228 3.1 85.9 1.0 OD1 A:ASN1225 3.2 76.1 1.0 OE2 A:GLU1228 3.2 83.9 1.0 OD1 C:ASN1225 3.3 69.6 1.0 OE2 B:GLU1228 3.3 85.4 1.0 ND2 B:ASN1225 3.5 73.7 1.0 ND2 A:ASN1225 3.6 75.8 1.0 CG B:ASN1225 3.6 74.9 1.0 CG A:ASN1225 3.7 75.7 1.0 CG D:ASN1225 3.7 75.4 1.0 ND2 D:ASN1225 3.9 79.7 1.0 CD C:GLU1228 3.9 83.4 1.0 CD B:GLU1228 3.9 85.0 1.0 CG C:ASN1225 4.0 68.7 1.0 OE1 B:GLU1228 4.0 85.6 1.0 CD D:GLU1228 4.0 84.5 1.0 ND2 C:ASN1225 4.0 64.2 1.0 CD A:GLU1228 4.1 79.7 1.0 OE2 D:GLU1228 4.2 81.3 1.0 OE2 C:GLU1228 4.4 81.7 1.0 OE1 A:GLU1228 4.7 75.7 1.0 CG A:GLU1228 4.9 74.6 1.0 CG C:GLU1228 5.0 81.0 1.0 CB D:ASN1225 5.0 74.5 1.0

Calcium binding site 3 out of 3 in the Crystal Structure of the Cavab Voltage-Gated Calcium Channel(Wild- Type, 2.7A)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Crystal Structure of the Cavab Voltage-Gated Calcium Channel(Wild- Type, 2.7A) within 5.0Å range: probe atom residue distance (Å) B Occ D:Ca1301 b:70.7 occ:1.00 O B:HOH1401 2.7 43.0 1.0 O A:HOH1401 2.9 44.2 1.0 O D:HOH1403 2.9 51.2 1.0 O D:HOH1401 2.9 42.5 1.0 O C:HOH1401 3.0 44.8 1.0 O B:HOH1404 3.1 46.4 1.0 O C:HOH1402 3.1 49.6 1.0 O A:HOH1402 3.6 49.8 1.0 O D:LEU1176 3.8 38.9 1.0 O B:LEU1176 4.1 36.4 1.0 O A:LEU1176 4.2 39.4 1.0 O C:LEU1176 4.4 36.5 1.0 N D:ASP1178 4.6 35.0 1.0 CA D:ASP1177 4.7 35.8 1.0 N B:ASP1178 4.7 39.3 1.0 OD1 B:ASP1177 4.7 47.2 1.0 CA B:ASP1177 4.8 38.3 1.0 C D:LEU1176 4.8 40.7 1.0 N A:ASP1178 4.9 39.2 1.0 OD1 D:ASP1177 5.0 36.1 1.0

L.Tang, T.M.El-Din, T.M.Swanson, D.C.Pryde, T.Scheuer, N.Zheng, W.A.Catterall. Structural Basis For Inhibition of A Voltage-Gated Ca(2+) Channel By Ca(2+) Antagonist Drugs. Nature V. 537 117 2016.
ISSN: ESSN 1476-4687
PubMed: 27556947
DOI: 10.1038/NATURE19102