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Calcium in PDB 5kxa: Selective Inhibition of Autotaxin Is Effective in Mouse Models of Liver Fibrosis

Enzymatic activity of Selective Inhibition of Autotaxin Is Effective in Mouse Models of Liver Fibrosis

All present enzymatic activity of Selective Inhibition of Autotaxin Is Effective in Mouse Models of Liver Fibrosis:
3.1.4.39;

Protein crystallography data

The structure of Selective Inhibition of Autotaxin Is Effective in Mouse Models of Liver Fibrosis, PDB code: 5kxa was solved by A.J.Stein, G.Bain, J.H.Hutchinson, J.F.Evans, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 65.84 / 2.59
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 55.100, 55.506, 70.075, 71.56, 79.75, 81.09
R / Rfree (%) 17.3 / 24.7

Other elements in 5kxa:

The structure of Selective Inhibition of Autotaxin Is Effective in Mouse Models of Liver Fibrosis also contains other interesting chemical elements:

Fluorine (F) 2 atoms
Zinc (Zn) 2 atoms
Chlorine (Cl) 1 atom

Calcium Binding Sites:

The binding sites of Calcium atom in the Selective Inhibition of Autotaxin Is Effective in Mouse Models of Liver Fibrosis (pdb code 5kxa). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Selective Inhibition of Autotaxin Is Effective in Mouse Models of Liver Fibrosis, PDB code: 5kxa:

Calcium binding site 1 out of 1 in 5kxa

Go back to Calcium Binding Sites List in 5kxa
Calcium binding site 1 out of 1 in the Selective Inhibition of Autotaxin Is Effective in Mouse Models of Liver Fibrosis


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Selective Inhibition of Autotaxin Is Effective in Mouse Models of Liver Fibrosis within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca904

b:57.5
occ:1.00
 O A:LEU746 2.0 46.8 1.0
OD1 A:ASP748 2.1 54.5 1.0
OD1 A:ASP740 2.4 49.8 1.0
OD1 A:ASP742 2.6 53.7 1.0
OD1 A:ASP744 2.7 50.9 1.0
C A:LEU746 3.2 47.5 1.0
CG A:ASP748 3.3 57.0 1.0
O A:HIS747 3.5 54.6 1.0
CG A:ASP744 3.5 51.3 1.0
CG A:ASP740 3.6 44.5 1.0
C A:HIS747 3.6 50.3 1.0
CG A:ASP742 3.6 52.2 1.0
OD2 A:ASP744 3.7 55.2 1.0
N A:ASP748 3.7 58.1 1.0
CA A:ASP748 3.8 54.3 1.0
OD2 A:ASP742 3.9 62.2 1.0
CA A:ASP740 3.9 51.6 1.0
CA A:LEU746 4.1 46.2 1.0
N A:LEU746 4.1 45.8 1.0
CB A:ASP740 4.1 51.6 1.0
CB A:ASP748 4.2 54.3 1.0
O A:PHE739 4.2 49.0 1.0
N A:HIS747 4.2 48.0 1.0
OD2 A:ASP748 4.2 59.3 1.0
CA A:HIS747 4.3 48.9 1.0
CB A:LEU746 4.4 47.8 1.0
OD2 A:ASP740 4.6 43.5 1.0
C A:ASP740 4.6 50.4 1.0
N A:ASP744 4.7 49.7 1.0
N A:ASP742 4.8 46.9 1.0
N A:TYR741 4.8 47.2 1.0
CB A:ASP744 4.9 49.2 1.0
CB A:ASP742 4.9 49.0 1.0
N A:ASP740 4.9 52.2 1.0
C A:PHE739 4.9 54.6 1.0
CD A:LYS752 4.9 63.2 1.0
N A:TYR743 5.0 46.5 1.0

Reference:

G.Bain, K.E.Shannon, F.Huang, J.Darlington, L.Goulet, P.Prodanovich, G.L.Ma, A.M.Santini, A.J.Stein, D.Lonergan, C.D.King, I.Calderon, A.Lai, J.H.Hutchinson, J.F.Evans. Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis. J. Pharmacol. Exp. Ther. V. 360 1 2017.
ISSN: ESSN 1521-0103
PubMed: 27754931
DOI: 10.1124/JPET.116.237156
Page generated: Mon Jul 15 07:06:19 2024

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